[1]葛丽丽,李玉宏.极速脉搏波技术评价非绝经期亚临床甲状腺功能减退患者颈部血管弹性功能及其影响因素[J].陕西医学杂志,2021,50(6):678-681,686.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.009]
　GE Lili,LI Yuhong.Evaluation of neck vascular elastic function by UFPWV and its influencing factors in non-menopausal patients with SCH[J].,2021,50(6):678-681,686.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.009]
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极速脉搏波技术评价非绝经期亚临床甲状腺功能减退患者颈部血管弹性功能及其影响因素
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年6期
页码:
678-681,686
栏目:
临床研究
出版日期:
2021-06-05

文章信息/Info

Title:
Evaluation of neck vascular elastic function by UFPWV and its influencing factors in non-menopausal patients with SCH
作者:
葛丽丽; 李玉宏
(锦州医科大学附属第一医院超声科,辽宁 锦州 121001)
Author(s):
GE Lili; LI Yuhong
(Department of Ultrasound,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)
关键词:
亚临床甲状腺功能减退;  极速脉搏波技术;  颈部血管弹性;  促甲状腺激素;  影响因素
Keywords:
Subclinical hypothyroidism;  Ultrafast pulse wave velocity technology;  Neck vascular elasticity;  Thyroid-stimulating hormone;  Influencing factor
分类号:
R 581.2
DOI:
DOI:10.3969/j.issn.1000-7377.2021.06.009
文献标志码:
A
摘要:
目的:应用极速脉搏波(UFPWV)技术评价非绝经期亚临床甲状腺功能减退(SCH)患者颈部血管弹性功能及其影响因素。方法:选取未绝经女性SCH患者104例,其促甲状腺激素(TSH)升高,但血清游离三碘甲腺原氨酸(FT3)和血清游离甲状腺素(FT4)正常,根据TSH水平高低分为轻度SCH组(TSH<10 mIU/L,54例)和重度SCH组(TSH≥10 mIU/L,50例)。另选取TSH、FT3、FT4均正常的健康体检者65例作为正常对照组。根据血管超声检查结果排除已形成颈动脉斑块或内-中膜增厚的患者,测量UFPWV评价颈部血管弹性的相关参数收缩早期传导速度(PWVBS)和收缩晚期传导速度(PWVES)。结果:三组收缩压、舒张压、年龄、总胆固醇、低密度脂蛋白和血糖比较差异均有统计学意义,且重度SCH组上述指标均高于正常对照组和轻度SCH组(均P<0.05)。三组PWVBS及PWVES比较差异均有统计学意义,且重度SCH组上述指标均高于正常对照组和轻度SCH组(均P<0.05)。除高密度脂蛋白外,SCH患者其余指标与PWVBS、PWVES均呈正相关关系(均P<0.01)。SCH患者PWVBS及PWVES影响因素均为收缩压、年龄、低密度脂蛋白。结论:重度SCH患者存在各个临床指标及动脉弹性的改变,TSH可能通过影响低密度脂蛋白来间接影响动脉弹性。
Abstract:
Objective:To apply ultrafast pulse wave velocity(UFPWV)to evaluate the neck vascular elasticity and its influencing factors in non-menopausal patients with subclinical hypothyroidism(SCH).Methods:A total of 104 premenopausal female SCH patients with elevated thyroid-stimulating hormone(TSH)but normal serum free triiodothyronine(FT3)and serum free thyroxine(FT4)were classified as mild SCH group(TSH<10 mIU/L,54 cases)and severe SCH group(TSH≥10 mIU/L,50 cases)according to the level of TSH.In addition,65 healthy subjects with normal TSH,FT3,and FT4 were selected as the normal control group.According to the results of vascular ultrasonography,patients with carotid plaque or intima-media thickening were excluded,and UFPWV was used to measure PWVBS and PWVES.Results:The differences in systolic blood pressure,diastolic blood pressure,age,total cholesterol,low-density lipoprotein,and blood glucose were statistically significant among the three groups,and the above indicators of the severe SCH group were higher than other two groups(all P<0.05).The differences of PWVBS and PWVES between the three groups were statistically significant,and the above indicators of the severe SCH group were higher than those of the normal control group and the mild SCH group(all P<0.05).Except for high-density lipoprotein,other indicators of SCH patients were positively correlated with PWVBS and PWVES(all P<0.01).The influencing factors of PWVBS and PWVES in SCH patients were systolic blood pressure,age,and low-density lipoprotein.Conclusion:There are changes in various clinical indicators and arterial elasticity in patients with severe SCH.TSH may indirectly affect arterial elasticity by affecting low-density lipoprotein.

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备注/Memo

备注/Memo:
基金项目:辽宁省兴辽英才计划项目(XLYC1802049)
更新日期/Last Update: 2021-06-07