[1]王 楠,席 锦.口腔癌发病危险因素分析[J].陕西医学杂志,2021,50(4):417-420.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.008]
　WANG Nan,XI Jin.Analysis of risk factors affecting oral cancer[J].,2021,50(4):417-420.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.008]
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口腔癌发病危险因素分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年4期
页码:
417-420
栏目:
临床研究
出版日期:
2021-04-05

文章信息/Info

Title:
Analysis of risk factors affecting oral cancer
作者:
王 楠; 席 锦
(陕西省结核病防治院,陕西 西安 710100)
Author(s):
WANG Nan; XI Jin
(Shaanxi Provincial Tuberculosis Control Institute,Xi'an 710100,China)
关键词:
口腔癌;  饮酒;  吸烟;  不良修复体;  口腔疾病;  危险因素
Keywords:
Oral cancer;  Drinking;  Smoking;  Bad prosthesis;  Oral disease;  Risk factor
分类号:
R 739.8
DOI:
DOI:10.3969/j.issn.1000-7377.2021.04.008
文献标志码:
A
摘要:
目的:探讨影响口腔癌发生的危险因素,并对其进行分析。方法:纳入收治的口腔癌患者130例作为口腔癌组,同期入院的非口腔疾病患者160例作为对照组。对两组的基础资料和饮食习惯进行调查,分析影响口腔癌发生的单因素,使用二元Logistic回归分析影响口腔癌发生的危险因素。结果:口腔癌组吸烟、口腔疾病史、不良修复体的发生率明显高于对照组(均P<0.05)。口腔癌组常食蔬菜水果、海鲜的发生率明显低于对照组(均P<0.05),常食烫热食物、经常饮酒的发生率明显高于对照组(均P<0.05)。吸烟、口腔疾病史、不良修复体、常食烫热食物、经常饮酒为口腔癌发生的独立危险因素(均P<0.05),常食蔬菜水果、常食海鲜为口腔癌发生的保护性因素(均P<0.05)。结论:口腔癌的发生与经常饮酒、吸烟、不良修复体、常食烫热食物、口腔疾病史等因素密切相关,临床中患者应减少烟草、酒精等的摄入,注意饮食均衡搭配和口腔卫生,增加蔬菜水果和海鲜产品的食用,并及时对口腔疾病进行临床干预,以降低口腔癌的发生风险。
Abstract:
Objective:To investigate and analyze the risk factors of oral cancer.Methods:130 patients with oral cancer were included as the oral cancer group,and 160 patients with non-oral diseases at the same time were selected as the control group.The basic data and eating habits of the two groups were investigated,and the single factors affecting the occurrence of oral cancer were analyzed,and the risk factors affecting the occurrence of oral cancer were analyzed by binary logistic regression.Results:The incidence of smoking,oral disease history,and bad restorations in the oral cancer group was significantly higher than that in the control group(P<0.05).The incidence of regular eating of vegetables,fruits and seafood in oral cancer group was significantly lower than that of control group(all P<0.05).The rate of eating vegetables,fruits and seafood in oral cancer group was significantly lower than that in control group(all P<0.05),and the incidence of eating hot food and drinking alcohol in oral cancer group was significantly higher than that in control group(all P<0.05).Smoking,oral disease history,bad prosthesis,eating hot food and drinking alcohol were the independent risk factors of oral cancer(all P<0.05).Eating fruits and vegetables and seafood were the protective factors of oral cancer(all P<0.05).Conclusion:The occurrence of oral cancer is closely related to frequent drinking,smoking,bad prosthesis,eating hot food,oral disease history.In clinical practice,patients should reduce the intake of tobacco and alcohol,pay attention to balanced diet and oral health,increase the consumption of vegetables,fruits and seafood,and timely carry out clinical intervention on oral diseases,so as to reduce the incidence of oral cancer.

参考文献/References:

[1] 冯 瑶.沉默SOCS1基因表达对人口腔癌KB细胞增殖的机制研究[J].陕西医学杂志,2020,49(10):1211-1214.
[2] 李永红,王祥财,许明君,等.中国中部地区1127例口腔癌预后影响因素分析[J].赣南医学院学报,2019,39(5):469-473,483.
[3] 刘 宇,罗治彬,王 彝,等.212例口腔癌患者的流行病学危险因素分析[J].实用癌症杂志,2014,29(2):160-161,167.
[4] 彭晔炜,刘景诗,许可葵,等.2009-2015年湖南省肿瘤登记地区口腔癌发病与死亡分析[J].中国肿瘤,2019,28(9):680-688.
[5] 张 济,杨中元,张 星,等.广东省口腔癌发病特征的单中心50年收治病例分析[J].口腔疾病防治,2017,25(1):13-20.
[6] 何保昌,高小叶,陈 法,等.口腔癌发病影响因素病例对照研究[J].中国公共卫生,2014,30(2):248-250.
[7] 刘冠邑,杨丽媛,付振涛,等.2014年山东省口腔癌发病和死亡水平分析[J].山东大学学报:医学版,2019,57(7):102-107.
[8] 秦帅华,李新明,李文鹿.口腔癌相关生存质量量表的系统性回顾研究[J].华西口腔医学杂志,2018,36(4):410-420.
[9] 张 圃,张春谊,王安辉,等.口腔癌的三级预防及临床实施[J].实用口腔医学杂志,2018,34(3):430-432.
[10] 郝春波,邓 伟,廖天安,等.EC-SOD和CYP 1A1-MspⅠ基因多态性及吸烟与口腔癌的相关性研究[J].实用预防医学,2015,9(10):14-18.
[11] 时小婷,潘亚萍.烟酒致癌物致口腔细胞恶性转化的研究进展[J].中国医科大学学报,2020,49(3):102-109.
[12] 周行红,黄 莹,袁 超,等.1483名北京市居民对口腔癌及相关知识的认知情况调查[J].北京大学学报:医学版,2020,52(2):323-331.
[13] 刘 兵,张爱泓,张 贞,等.口腔癌发病的危险性因素及血清炎症因子的变化情况分析[J].实用预防医学,2018,25(6):731-734.
[14] 程俊鑫,白贺天,常治楠,等.口腔黏膜癌前病变和口腔癌动物模型的研究进展[J].华西口腔医学杂志,2020,38(2):90-96.
[15] 吴东蕾,刘 静.氧化应激损伤与口腔疾病相关性的研究进展[J].国际口腔医学杂志,2019,46(1):68-73.
[16] 陈 法,何保昌,刘芳萍,等.男性口腔癌与膳食因素关系病例对照研究[J].中国公共卫生,2016,32(6):811-814.
[17] 邵丹彤,李敏娟,陈 茹,等.口腔菌群影响因素及其与上消化道肿瘤关联研究进展[J].中华流行病学杂志,2020,41(7):1160-1164.
[18] 陈 青,林李嵩,陈 林,等.硒元素与口腔癌发病关联的病例对照研究[J].中华流行病学杂志,2019,40(7):810-814.
[19] 林亮坤.膳食脂肪酸及其相关酶基因多态性与口腔颌面部良性肿瘤的关联研究[D].福州:福建医科大学,2019.
[20] 曾晓娟,台保军.现代膳食模式与口腔健康[J].中华口腔医学杂志,2020,55(10):704-709.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生健康委员会科研基金资助项目(2018D046)
更新日期/Last Update: 2021-04-06