[1]马小霞,貌彦昀.细胞角蛋白19片段抗原、糖抗原19-9与鳞状细胞癌抗原联合检测在食管癌诊断中的价值研究[J].陕西医学杂志,2021,50(3):359-361,365.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.027]
　MA Xiaoxia,MAO Yanyun.Value of combined detection of CYFRA21-1,CA19-9 and SCC-Ag in diagnosis of esophageal cancer[J].,2021,50(3):359-361,365.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.027]
点击复制

细胞角蛋白19片段抗原、糖抗原19-9与鳞状细胞癌抗原联合检测在食管癌诊断中的价值研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年3期
页码:
359-361,365
栏目:
临床检验
出版日期:
2021-03-01

文章信息/Info

Title:
Value of combined detection of CYFRA21-1,CA19-9 and SCC-Ag in diagnosis of esophageal cancer
作者:
马小霞1; 貌彦昀2
(1.延安大学附属医院检验科,陕西 延安 716000; 2.延安大学附属医院东关心脑血管病区检验科,陕西 延安 716000)
Author(s):
MA Xiaoxia; MAO Yanyun
(Department of Laboratory Medicine,Affiliated Hospital of Yan'an University,Yan'an 716000,China)
关键词:
细胞角蛋白19片段抗原;  糖抗原19-9;  鳞状细胞癌抗原;  食管癌;  联合检测;  诊断
Keywords:
CYFRA21-1;  CA19-9;  SCC-Ag;  Esophageal cancer;  Combined detection;  Diagnosis
分类号:
R 735.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.03.027
文献标志码:
A
摘要:
目的:探讨细胞角蛋白19片段抗原(CYFRA21-1)、糖抗原19-9(CA19-9)与鳞状细胞癌抗原(SCC-Ag)联合检测在食管癌诊断中的价值。方法:选取食管癌患者140例为观察组,同时选取同期健康体检者90例为对照组。检测两组外周血CYFRA21-1、CA19-9及SCC-Ag并进行比较,分析联合检测对食管癌的诊断价值。结果:观察组手术前后CYFRA21-1、CA19-9与SCC-Ag水平均高于对照组,且手术后各指标水平均低于手术前(均P<0.05)。观察组中发生复发转移者的CYFRA21-1、CA19-9与SCC-Ag水平均高于手术前(均P<0.05)。随着临床分期的递增,观察组患者CYFRA21-1、CA19-9与SCC-Ag水平均呈升高趋势(均P<0.05)。CYFRA21-1、CA19-9与SCC-Ag三种指标联合诊断食管癌的阳性率明显高于各单项检测(均P<0.05)。结论:血清CYFRA21-1、CA19-9与SCC-Ag联合检测相对于单项检测在食管癌诊断中的价值更高,可提高疾病检出率。
Abstract:
Objective:To explore the value of combined detection of CYFRA21-1,CA19-9 and SCC-Ag in the diagnosis of esophageal cancer.Methods:A total of 140 patients with esophageal cancer were selected as the observation group,and 90 patients who underwent a physical examination during the same period were selected as the control group.The peripheral blood CYFRA21-1,CA19-9 and SCC-Ag were detected and compared between the two groups,and the diagnostic value of combined detection for esophageal cancer was analyzed.Results:The levels of CYFRA21-1,CA19-9 and SCC-Ag in the observation group before and after operation were higher than those in the control group,and the levels of each index after the operation were lower than those before the operation(all P<0.05).The levels of CYFRA21-1,CA19-9 and SCC-Ag in the observation group who had recurrence and metastasis were higher than those before surgery(all P<0.05).With the increasing clinical stage,the levels of CYFRA21-1,CA19-9 and SCC-Ag in the observation group showed an increasing trend(all P<0.05).The positive rate of CYFRA21-1,CA19-9 and SCC-Ag in the combined diagnosis of esophageal cancer was significantly higher than that of single test(all P<0.05).Conclusion:The combined detection of serum CYFRA21-1,CA19-9 and SCC-Ag is more valuable than single detection in the diagnosis of esophageal cancer,which can increase the disease detection rate.

参考文献/References:

[1] 王 冠,曹 锦,刘浩聪,等.局部复发性食管癌放疗的研究进展[J].现代肿瘤医学,2020,28(8):1402-1406.
[2] Okaru AO,Rullmann A,Farah A,et al.Comparative oesophageal cancer risk assessment of hot beverage consumption(coffee,mate and tea):The margin of exposure of PAH vs very hot temperatures[J].BMC Cancer,2018,18(1):236.
[3] 雷 田.血清细胞角蛋白19片段及鳞状上皮细胞癌抗原水平检查在食管癌诊断中的应用[J].黑龙江医学,2020,44(3):317-319.
[4] 董彩霞.血清肿瘤标志物水平及其联合检测对食管癌的诊断意义研究[J].医药与保健,2019,27(11):148-150.
[5] 马东阳,周浩本,杨 峰,等.中药配合放射治疗中晚期食管癌30例[J].陕西中医,2008,29(1):12-13.
[6] Hong S,Dan H,Sinan W,et al.Baseline metabolic risk score and postsurgical esophageal cancer-specific mortality:The fujian prospective investigation of cancer(FIESTA)study[J].Journal of Cancer,2018,9(7):1173-1181.
[7] 杜春然,王彦明,侯申岩,等.CYFRA21-1、CA19-9和SCCAg检测在食管癌诊断中的价值研究[J].癌症进展,2018,16(2):186-188.
[8] 梁卫平.血清CYFRA21-1、CA19-9和SCC的测定对食管癌的诊断价值研究[J].中国卫生标准管理,2018,9(7):108-110.
[9] 张 猛.血CEA、NSE、CYFRA21-1和SCC联合检测在肺癌诊断中的应用研究[J].中外医疗,2020,39(9):198-200.
[10] 张 颖,董秀鹏,杜 静,等.肿瘤标志物CYFRA21-1、SCC、CEA、NSE、CA125检验在肺癌诊断中的价值[J].现代肿瘤医学,2018,26(11):1701-1703.
[11] 于卫民,姬建胜,王冬冬.不同血清肿瘤标志物联合检测在老年食管癌早期诊断中的价值[J].中国卫生工程学,2018,17(1):97-98.
[12] 张 静.多项肿瘤标志物联合检测在食管癌诊断中的应用价值[J].中国卫生检验杂志,2020,30(3):67-69.
[13] 刘志华,卢旭妹,容 亓.血清标志物CYFRA21-1、SCC、NSE、CEA及ProGRP联合检测在非小细胞性肺癌中的诊断价值[J].河北医药,2019,41(10):26-30.
[14] 陈真云,盛修贵,李秀敏.SCCAg、CYFRA21-1、CEA联合检测在中晚期及复发宫颈鳞癌诊断和治疗中的临床价值[J].肿瘤学杂志,2013,19(8):595-599.
[15] 钱爱丽,李水霞.CYFRA21-1、CEA和SCCA的联合检测在呼吸系统恶性肿瘤和良性疾病鉴别诊断中的临床意义探讨[J].中国实用医药,2020,15(5):42-43.
[16] 李海霞.联合检测血清CYFRA21-1和SCC-Ag水平在诊断食管癌中的应用价值[J].临床医药文献电子杂志,2017,4(95):18657.
[17] 张丹华.细胞角蛋白19与鳞状细胞癌抗原联合检测在宫颈癌早期筛查及疗效评估中的应用[J].检验医学与临床,2014,11(23):3296-3298.
[18] 范琳琳,于小汇,张 姗.五种血清肿瘤标志物联合检测在肺癌诊断中的应用价值[J].中国药物经济学,2017,12(4):137-139.
[19] 王 玲,申 鸿.癌胚抗原、糖类抗原、CA125、血管生成素、细胞角蛋白19片段及甲胎蛋白检测在肺癌诊断中的临床研究[J].陕西医学杂志,2019,48(8):1080-1084.
[20] 付卫云,陈冬玲,卞 华,等.血清CYFRA21-1、CA19-9和SCC的测定对食管癌的诊断价值研究[J].重庆医学,2017,46(12):1672-1674.

相似文献/References:

[1]宋亚邛,胡海燕△.VEGF、TGF-β1、CA19-9、CA242和DKK1联合检测对早期胰腺癌临床诊断价值研究*[J].陕西医学杂志,2020,49(2):237.
　SONG Yaqiong,HU Haiyan..Clinical value analysis of combined examination of VEGF,TGF-β1,CA19-9,CA242 and DKK1 in patients with early pancreatic cancer[J].,2020,49(3):237.

备注/Memo

备注/Memo:
基金项目:陕西省延安市医学科学技术项目(20171108-2)
更新日期/Last Update: 2021-03-04