[1]胡瑞杰,宋民喜,徐 琳,等.吡格列酮二甲双胍对多囊卵巢综合征不孕患者糖脂代谢及妊娠率的影响[J].陕西医学杂志,2021,50(2):221-224.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.024]
　HU Ruijie,SONG Minxi,XU Lin,et al.Effect of pioglitazone and metformin on glucose-lipid metabolism and pregnancy rate in treating infertile patients with PCOS[J].,2021,50(2):221-224.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.024]
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吡格列酮二甲双胍对多囊卵巢综合征不孕患者糖脂代谢及妊娠率的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年2期
页码:
221-224
栏目:
药物与临床
出版日期:
2021-02-05

文章信息/Info

Title:
Effect of pioglitazone and metformin on glucose-lipid metabolism and pregnancy rate in treating infertile patients with PCOS
作者:
胡瑞杰1; 宋民喜1; 徐 琳1; 彭慧霞2
(1.西安市人民医院 西安市第四医院,陕西 西安 710004; 2.西安交通大学第二附属医院,陕西 西安 710004)
Author(s):
HU Ruijie; SONG Minxi; XU Lin; PENG Huixia
(Xi'an People's Hospital,Xi'an 710004,China)
关键词:
多囊卵巢综合征;  不孕;  治疗;  吡格列酮;  二甲双胍;  胰岛素抵抗
Keywords:
Polycystic ovary syndrome;  Infertile;  Therapy;  Pioglitazone;  Metformin;  Insulin resistance
分类号:
R 711.6
DOI:
DOI:10.3969/j.issn.1000-7377.2021.02.024
文献标志码:
A
摘要:
目的:观察吡格列酮二甲双胍复方制剂治疗多囊卵巢综合征不孕患者的糖脂代谢水平及妊娠情况。方法:选取多囊卵巢综合征不孕患者80例为研究对象,随机分为观察组和对照组,观察组给予吡格列酮二甲双胍治疗,对照组给予二甲双胍治疗,两组均治疗3个月; 比较两组治疗前后性激素水平、糖脂代谢水平及半年内妊娠率。结果:两组患者治疗后胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、血清睾酮(T)、促黄体生成素(LH)、LH/FSH与治疗前相比均显著降低(均P<0.05),观察组降低幅度优于对照组,且有统计学差异(P<0.05); 两组患者体重指数(BMI)较治疗前均有所下降,但两组间比较无统计学差异(均P>0.05)。与对照组相比,治疗后观察组卵泡刺激素(FSH)、雌二醇(E2)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平变化均无统计学差异(均P>0.05); 观察组患者经治疗后月经恢复比例及妊娠率均高于对照组,差异均有统计学意义(均P<0.05)。结论:吡格列酮二甲双胍复方制剂较二甲双胍单药治疗多囊卵巢综合征不孕患者,可更加显著减轻胰岛素抵抗、改善性激素及糖脂代谢水平,同时提高患者月经恢复率及妊娠率。
Abstract:
Objective:To analyze the effect of pioglitazone and metformin on glucose-lipid metabolism and pregnancy rate in treating infertile patients with PCOS.Methods:80 infertile patients with PCOS were selected and randomly divided into observation group and control group.Patients in the observation group were treated with pioglitazone and metformin.Patients in the control group was treated with metformin only.After 3 months of treatment,the levels of sex hormones,glucose-lipid metabolism and pregnancy rate in 6 months were compared between the two groups.Results:After treatment,the insulin resistance index(HOMA-IR),triglycerides(TG),serum testosterone(T),luteinizing hormone(LH),and LH/FSH were significantly decreased(all P<0.05),and the decrease of the observation group was better than that of the control group(P<0.05).The body mass index(BMI)of the two groups was decreased in comparison with that before treatment,but there was no statistical difference between the two groups(all P>0.05).The changes of follicle stimulating hormone(FSH),estradiol(E2),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C))levels in the observation group after treatment were not statistically different from those in the control group(all P>0.05).The menstrual improvement rate and pregnancy rate of the observation group after treatment were higher than those in the control group(all P<0.05).Conclusion:Compared with metformin monotherapy in the treatment of infertility patients with PCOS,the pioglitazone-metformin compound preparation can significantly reduce insulin resistance,improve the level of sex hormones and glucose-lipid metabolism,and increase the menstrual improvement rate and pregnancy rate of patients.

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备注/Memo

备注/Memo:
基金项目:陕西省科学技术研究发展计划项目(2011K12-03-13)
更新日期/Last Update: 2021-01-28