[1]李钢锋,党江波.老年白内障术后角膜内皮细胞严重丢失情况及影响因素研究[J].陕西医学杂志,2021,50(2):177-179,183.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.013]
　LI Gangfeng,DANG Jiangbo.Severe corneal endothelial cell loss after cataract surgery in the elderly and its influencing factors[J].,2021,50(2):177-179,183.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.013]
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老年白内障术后角膜内皮细胞严重丢失情况及影响因素研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年2期
页码:
177-179,183
栏目:
临床研究
出版日期:
2021-02-05

文章信息/Info

Title:
Severe corneal endothelial cell loss after cataract surgery in the elderly and its influencing factors
作者:
李钢锋1; 党江波2
(1.杨凌示范区医院眼科,陕西 杨凌712100; 2.榆林市中医医院眼科,陕西 榆林719000)
Author(s):
LI Gangfeng; DANG Jiangbo
(Department of Ophthalmology,Yangling District Hospital,Yangling 712100,China)
关键词:
老年白内障;  超声乳化手术;  角膜内皮细胞;  丢失;  影响因素
Keywords:
Senile cataract;  Phacoemulsification;  Corneal endothelial cells;  Lose;  Influencing factor
分类号:
R 776.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.02.013
文献标志码:
A
摘要:
目的:探讨老年白内障术后角膜内皮细胞严重丢失情况及影响因素。方法:对116例老年白内障患者的临床资料进行回顾性分析,记录患者术前、术后2个月角膜内皮细胞丢失情况,对患者术后角膜内皮细胞严重丢失的影响因素进行分析。结果:患者术后2个月角膜内皮细胞密度(CED)、六角形细胞比例均低于术前(均P<0.05),术后2个月细胞变异度(CV)高于术前(P<0.05); 术后2个月116例患者角膜内皮细胞严重丢失发生率52.58%,单因素与多因素分析显示年龄、晶状体Emery硬核分级、超声乳化时间、超声能量、累积释放能量为老年白内障术后角膜内皮细胞严重丢失的独立影响因素(OR值分别为1.640、2.232、2.208、1.887、1.738,95% CI值分别为1.362～6.817、2.089～7.146、1.948～4.889、1.506～3.912、1.304～9.484,均P<0.05)。结论:老年白内障患者术后发生角膜内皮细胞严重丢失风险高,且年龄、晶状体Emery硬核分级、超声乳化时间、超声能量、累积释放能量均是老年白内障术后角膜内皮细胞严重丢失的独立影响因素。
Abstract:
Objective:To investigate the serious loss of corneal endothelial cells after cataract surgery in the elderly and its influencing factors.Methods:The clinical data of 116 elderly cataract patients were retrospectively analyzed.The loss of corneal endothelial cells was recorded before and 2 months after the operation.The factors affecting the severe loss of corneal endothelial cells after the operation were analyzed.Results:The corneal endothelial cell density(CED)and the proportion of hexagonal cells of the patient 2 months after the operation were lower than preoperative(all P<0.05),and the cell variability(CV)of the patient was higher than preoperative(P<0.05).The incidence of severe corneal endothelial cell loss in 116 patients 2 months after surgery was 52.58%.Univariate and multivariate analysis showed that age,crystalline lens Emery hard nucleus grading,phacoemulsification time,ultrasound energy,and cumulative release energy were independent influencing factors for the serious loss of corneal endothelial cells after senile cataract surgery(OR=1.640,2.232,2.208,1.887,1.738,95%CI:1.362-6.817,2.089-7.146,1.948-4.889,1.506-3.912,1.304-9.484,all P<0.05).Conclusion:The risk of severe corneal endothelial cell loss is high in elderly cataract patients after surgery.Age,crystalline lens Emery hard nucleus grading,phacoemulsification time,ultrasound energy,and cumulative released energy are all independent influencing factors for severe corneal endothelial cell loss after senile cataract surgery.

参考文献/References:

[1] Stuart K,Mingguang H.Risk factors for age-related cataract:Editorial[J].Clinical and Experimental Ophthalmology,2018,46(4):327-328.
[2] 李海燕,马 波,柴 芳,等.前房注气术治疗白内障超声乳化术后角膜后弹力层脱离临床研究[J].陕西医学杂志,2019,48(9):1182-1185.
[3] 王 琦,左国近.中药熏蒸治疗白内障术后并发干眼疗效观察[J].陕西中医,2017,38(7):934-935.
[4] 秦文广,王 艳,杨 帅.除风益损汤联合西药治疗白内障术后虹膜睫状体炎随机平行对照研究[J].陕西中医,2018,39(7):925-927.
[5] 焦旭芳.小切口超声乳化白内障手术对白内障治疗效果及角膜内皮丢失率的影响探究[J].健康大视野,2019,1(22):221-222.
[6] 卢 奕.解读眼科临床指南(PPP)规范诊治理念[J].中国眼耳鼻喉科杂志,2018,18(2):79-81.
[7] 江 音,史伟云,李凤洁,等.双切口囊外白内障摘除术治疗低角膜内皮细胞数硬核白内障的疗效探讨[J].中华眼科杂志,2020,56(2):126-130.
[8] Lee HM,Kim KN,Park KS,et al.Relationship between tube parameters and corneal endothelial cell damage after ahmed glaucoma valve implantation:A comparative study[J].Journal of Clinical Medicine,2020,9(8):2546-2549.
[9] Kunishige T,Takahashi H.Effects of combinations of ophthalmic viscosurgical devices and suction flow rates on the corneal endothelial cell damage incurred during phacoemulsification[J].Journal of Ophthalmology,2020,20(10):1-5.
[10] 曹端荣,龚静青,金 玲,等.白内障患者术后角膜内皮细胞计数减少的多因素分析[J].国际眼科杂志,2018,18(4):716-719.
[11] Kentaro I,Shogo A,Yuji T,et al.Prospective cohort study of corneal endothelial cell loss after baerveldt glaucoma implantation[J].PLoS One,2018,13(7):1342-1345.
[12] 曾洪波,宋春华,彭 璟,等.超声乳化术与小切口非超声乳化术治疗老年性白内障临床疗效对比研究[J].陕西医学杂志,2018,47(11):1400-1402.
[13] 李盼盼,管 宇,陈诵惟,等.2.4 mm透明角膜单切口超声乳化白内障吸出术对角膜的影响[J].眼科新进展,2019,39(1):59-63.
[14] 高青松,邸 新,何 伟.飞秒激光辅助的白内障手术与传统超声乳化手术对角膜内皮细胞形态及功能的影响比较[J].国际眼科杂志,2018,18(4):671-673.
[15] 吴尚国,宋 强,赵华平,等.飞秒激光辅助超声乳化术对白内障患者角膜内皮细胞的影响[J].国际眼科杂志,2017,17(4):749-751.

更新日期/Last Update: 2021-01-28