[1]杨 旭,张致英,康龙丽,等.环状RNA与代谢性疾病研究进展[J].陕西医学杂志,2021,50(1):126-128，封3.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.033]
　YANG Xu,ZHANG Zhiying,KANG Longli,et al.Advances in circular RNA and metabolic diseases[J].,2021,50(1):126-128，封3.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.033]
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环状RNA与代谢性疾病研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
126-128，封3
栏目:
综述
出版日期:
2021-01-05

文章信息/Info

Title:
Advances in circular RNA and metabolic diseases
作者:
杨 旭; 张致英; 康龙丽; 马利锋
(西藏民族大学环境与疾病相关基因研究高校重点实验室,陕西 咸阳 712082)
Author(s):
YANG Xu; ZHANG Zhiying; KANG Longli; MA Lifeng
(Key Laboratory of Environment and Disease-related Gene Research,Xizang Minzu University,Xianyang 712082,China)
关键词:
环状RNA;  海绵作用;  肥胖症;  糖尿病;  高血压;  心血管疾病;  肿瘤
Keywords:
CircRNA;  Sponge action;  Obesity;  Diabetes;  Hypertension;  Cardiovascular disease;  Tumour
分类号:
R 589
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.033
文献标志码:
A
摘要:
环状RNA(circRNA)是在近些年被高度关注的一种非编码RNA,由一个或多个外显子通过异常的反向剪接机制形成的共价闭合的环状结构,这种环状结构可以受到外切酶的保护,比线性RNA更加稳定。随着高通量测序技术和生物信息学的迅速发展,人类多种疾病被检测出存在多种circRNA的表达,如肥胖症、糖尿病、高血压、心血管疾病和肿瘤等代谢性疾病,而且它有望成为诊断疾病的新兴生物标记物和治疗靶点。现对circRNA的生物学特征和功能以及它与多种代谢性疾病发病机制潜在关系的研究进展进行综述。
Abstract:
Circular RNA(circRNA)is a kind of non-coding RNA that has been highly concerned in recent years.It is a covalently closed circular structure formed by one or more exons through abnormal reverse splicing mechanism.This circular structure can be protected by exonuclease and is more stable than linear RNA.With the rapid development of high-throughput sequencing technology and bioinformatics,circRNA expression has been detected in a variety of human diseases,such as obesity,diabetes,hypertension,cardiovascular disease,tumour and other metabolic diseases.It is expected to become an emerging biomarker for the diagnosis of diseases and a therapeutic target.This review will focus on the biological characteristics and functions of circRNA and its potential relationship with the pathogenesis of various metabolic diseases.

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备注/Memo

备注/Memo:
基金项目:西藏自治区自然科学基金资助项目[XZ 2019ZRG-28(Z),XZ2019ZRG-133,XZ2018ZRG-88(Z)]; 西藏自治区科技计划项目(XZ201801-GB03); 西藏自治区高校青年教师创新支持计划项目(QCZ2016-27)
更新日期/Last Update: 2021-01-05