[1]周衍香,梅 波,刘中洋.噻托溴铵联合沙美特罗替卡松治疗哮喘-慢性阻塞性肺疾病重叠综合征疗效Meta分析[J].陕西医学杂志,2021,50(1):111-116.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.030]
　ZHOU Yanxiang,MEI Bo,LIU Zhongyang.Meta analysis of the efficacy of tiotropium bromide combined with salmeterol and ticassone in treatment of asthma-COPD overlap syndrome[J].,2021,50(1):111-116.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.030]
点击复制

噻托溴铵联合沙美特罗替卡松治疗哮喘-慢性阻塞性肺疾病重叠综合征疗效Meta分析
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
111-116
栏目:
Meta分析
出版日期:
2021-01-05

文章信息/Info

Title:
Meta analysis of the efficacy of tiotropium bromide combined with salmeterol and ticassone in treatment of asthma-COPD overlap syndrome
作者:
周衍香1; 梅 波2; 刘中洋2
(1.锦州医科大学解放军联勤保障部队第九六七医院研究生培养基地,辽宁 大连 116021; 2.解放军联勤保障部队第九六七医院呼吸内科,辽宁 大连 116021)
Author(s):
ZHOU Yanxiang; MEI Bo; LIU Zhongyang
(Postgraduate training base,the 967th Hospital of the PLA Joint Logistic Support Force,Jinzhou Medical University,Dalian 116021,China)
关键词:
噻托溴铵;  沙美特罗替卡松;  治疗;  哮喘慢阻肺重叠综合征;  Meta分析
Keywords:
Tiotropium bromide;  Salmeterol and ticassone;  Treatment;  Asthma-COPD overlap syndrome;  Meta analysis
分类号:
R 562.25
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.030
文献标志码:
A
摘要:
目的:结合临床实验数据,从循证医学的角度综合分析噻托溴铵联合沙美特罗替卡松治疗哮喘-慢阻肺重叠综合征(ACOS)的疗效。方法:运用计算机检索中国知网(CNKI)、万方、维普(VIP)、SCI、Embase、PubMed等中英文数据库。搜集2020年1月前发表的有关噻托溴铵联合沙美特罗替卡松治疗ACOS的中英文随机对照试验,检索时间为2010年1月1日至2020年1月1日。由2位研究员仔细筛选符合纳入和排除标准的文献后汇总意见并提取相关信息,然后通过Cochrane偏倚风险评估工具评价纳入文献的质量,最后使用RevMan 5.3软件对纳入文献进行Meta分析。结果:总共纳入16个噻托溴铵联合沙美特罗替卡松治疗ACOS的中英文随机对照试验,共有患者1463例。Meta分析结果显示,噻托溴铵联合沙美特罗替卡松治疗ACOS其治疗有效性(RR=1.26,Z=6.59,P<0.00001,95%CI:1.18～1.36),生活质量评分(MD=15.67,Z=7.19,P<0.00001,95%CI:11.40～19.94),每年急性发作次数(MD=-7.41,P<0.00001,Z=24.19,95%CI:-8.01～-6.81),第一秒用力呼吸容积(FEV1)(SMD=0.95,P<0.00001,Z=4.67,95%CI:0.55～1.35),用力肺活量(FVC)(MD=0.43,P=0.007,Z=0.43,95%CI:0.12～0.74),FEV1/FVC(MD=9.40,P<0.00001,Z=10.71,95%CI:7.68～11.12),试验组均优于对照组。结论:噻托溴铵联合沙美特罗替卡松治疗ACOS疗效确切,具有良好的临床应用价值。
Abstract:
Objective:To comprehensively analyze the efficacy of tiotropium bromide combined with salmeterol and ticassone in the treatment of asthma-chronic obstructive pulmonary overlap syndrome(ACOS)from the perspective of evidence-based medicine.Methods:The databases such as CNKI,Wanfang,VIP,SCI,Embase,PubMed were searched.The Chinese and English randomized controlled trials of tiotropium bromide combined with salmeterol and ticassone in the treatment of ACOS published from January 1,2010 to January 1,2020 were collected.Two researchers carefully screened the documents that met the inclusion and exclusion criteria,summarized their opinions and extracted relevant information,then evaluated the quality of the included literature using the Cochrane risk assessment tool,and finally used RevMan 5.3 software to conduct a Meta analysis of the included literature.Results:A total of 16 randomized controlled trials were included,with a total of 1463 patients.Meta-analysis results showed that the effectiveness of tiotropium bromide combined with salmeterol and ticassone in the treatment of ACOS(RR=1.26,Z=6.59,P<0.00001,95%CI:1.18～1.36),quality of life score(MD=15.67,Z=7.19,P<0.00001,95%CI:11.40～19.94),the number of acute attacks per year(MD=-7.41,P<0.00001,Z=24.19,95%CI:-8.01～-6.81),FEV1(SMD=0.95,P<0.00001,Z=4.67,95%CI:0.55～1.35),FVC(MD=0.43,P<0.007,Z=0.43,95%CI:0.12-0.74),FEV1/FVC(MD=9.40,P<0.00001,Z=10.71,95%CI:7.68～11.12),the test group is better than the control group.Conclusion:The combination of tiotropium bromide and salmeterol and ticassone in the treatment of ACOS is effective and has good clinical application value.

参考文献/References:

[1] He T.The influency of Nigella sativa for asthma control:a Meta-analysis[J].Am J Emerg Med,2019,29:735.
[2] Tamayo UI,Altzibar JM,Mughini GL.Exacerbations of chronic obstructive pulmonary disease(COPD):an ecological study in the basque country,Spain(2000-2011)[J].COPD,2016,13(6):726-733.
[3] 彭秋凤,叶 奎,高静珍.哮喘-慢阻阻塞性肺疾病重叠综合征的诊疗进展[J].医疗装备,2019,32(20):193-195.
[4] 邓玎玎,周爱媛,双庆翠,等.呼出气一氧化氮测定对支气管哮喘-慢性阻塞性肺疾病重叠综合征的诊断价值[J].中华结核和呼吸杂志,2017,40(2):98-101.
[5] 陈建伟.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻肺重叠综合征的临床效果分析[J].饮食保健,2018,5(29):42-43.
[6] 程 丽.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻肺重叠综合征的临床价值体会[J].中国社区医师,2018,34(30):26-27.
[7] 高丕晔,白 洁.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻肺重叠综合征的临床有效性[J].中西医结合心血管病电子杂志,2018,6(7):195.
[8] 管成艳.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻阻塞性肺疾病重叠综合征的临床评价及对日常生活质量、急性发作的影响[J].中国医药指南,2019,17(17):165-166.
[9] 廉志宏,乌日汗.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻肺重叠综合征的临床效果分析[J].中国实用医药,2018,13(32):101-102.
[10] 刘雪琴,关晓暄,孙立军.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻肺重叠综合征的临床评价[J].临床肺科杂志,2017,22(3):513-516.
[11] 刘 燕.噻托溴铵联合沙美特罗/氟替卡松治疗慢阻肺重叠综合征并发哮喘对肺功能的影响研究[J].科学养生,2019,22(9):246.
[12] 瞿美君.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻肺重叠综合征的临床效果观察[J].世界最新医学信息文摘,2019,19(66):230-232.
[13] 王俊敏.沙美特罗/替卡松联合噻托溴铵治疗哮喘-慢阻阻塞性肺疾病重叠综合征的效果观察[J].中国乡村医药,2017,24(16):31-32.
[14] 吴 娜.沙美特罗/氟替卡松治疗哮喘-COPD重叠综合征的效果[J].深圳中西医结合杂志,2019,29(11):99-100.
[15] 杨玲玲.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻肺重叠综合征的临床效果[J].中外医学研究,2019,17(4):133-135.
[16] 游伟玲,李晓珍,张 锋,等.沙美特罗/替卡松联合噻托溴铵吸入治疗哮喘-慢阻阻塞性肺疾病重叠综合征的效果[J].中国乡村医药,2017,24(7):17-18.
[17] 戢太兵,艾红艳,秦永刚,等.哮喘-慢阻肺重叠综合征采用沙美特罗氟替卡松分别联合噻托溴铵和复方异丙托溴铵治疗的效果对比[J].中外医学研究,2019,17(6):32-33.
[18] 吴承祥.沙美特罗/替卡松联合噻托溴铵治疗哮喘-慢阻肺重叠综合征效果观察[J].中国乡村医药,2018,25(1):14-15.
[19] 张 梅.沙美特罗替卡松粉吸入剂联合噻托溴胺粉吸入剂治疗哮喘-慢阻肺重叠综合征的疗效评价[J].医药前沿,2015,5(34):34-35.
[20] 倪敏讷,童朝晖.噻托溴铵联合沙美特罗/氟替卡松治疗哮喘-慢阻肺重叠综合征122例[J].中国生化药物杂志,2017,37(8):206-207.
[21] Barrecheguren M,Esquinas C,Miravitlles M.The asthmachronic obstructive pulmonary disease overlap syndrome(ACOS):Opportunities and challenges[J].Curr Opin Pulm Med,2015,21:74-79.
[22] 张卓红.吸入激素对哮喘-慢阻肺重叠综合征患者气道重塑及内皮细胞功能的影响[J].陕西医学杂志,2016,45(8):1040-1042.
[23] Xu H.Inhaled Glucocorticoid with or without tiotropium bromide for asthma-chronic obstructive pulmonary disease overlap syndrome[J].J Coll Physicians Surg Pak,2019,29:249-252.
[24] Araújo D,Padrao E,Morais-Almeida M,et al.Asthma-chronic obstructive pulmonary disease overlap syndrome-Literature review and contributions towards a Portuguese consensus[J].Rev Port Pneumol(2006),2017,23:90-99.
[25] 李学玲,张春峰.不同剂量舒利迭治疗老年中重度稳定期慢性阻塞性肺疾病疗效观察[J].陕西医学杂志,2016,45(9):1224-1225.
[26] Ohbayashi H.Comparison of the rapid effects of single inhalations of formoterol and tiotropium bromide on respiratory function and COPD symptoms in a randomized crossover study[J].Respir Investig,2017,55:348-356.
[27] 曹小花,梅安存.沙美特罗替卡松联合噻托溴铵治疗哮喘-慢阻肺重叠综合征的临床效果[J].临床医学研究与实践,2018,3(27):47-48.

更新日期/Last Update: 2021-01-05