[1]李 静,常 盼,王西辉,等.血清晚期蛋白氧化产物联合转化生长因子β检测在高血压肾病中的诊断价值[J].陕西医学杂志,2021,50(1):26-28,47.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.006]
　LI Jing,CHANG Pan,WANG Xihui,et al.Diagnostic value of combined detection of serum AOPP and TGF-β in hypertensive nephropathy[J].,2021,50(1):26-28,47.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.006]
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血清晚期蛋白氧化产物联合转化生长因子β检测在高血压肾病中的诊断价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
26-28,47
栏目:
临床研究
出版日期:
2021-01-05

文章信息/Info

Title:
Diagnostic value of combined detection of serum AOPP and TGF-β in hypertensive nephropathy
作者:
李 静; 常 盼; 王西辉; 王建榜; 吴 娟
(西安医学院第二附属医院心内科 暨陕西省心血管内科疾病临床研究分中心,陕西 西安 710038)
Author(s):
LI Jing; CHANG Pan; WANG Xihui; WANG Jianbang; WU Juan
(Department of Cardiology,the Second Affiliated Hospital of Xi'an Medical University and Shaanxi Provincial Cardiovascular Disease Clinical Research Center,Xi'an 710038,China)
关键词:
高血压肾病;  转化生长因子β;  血清晚期蛋白氧化产物;  诊断;  对比研究
Keywords:
Hypertensive nephropathy;  TGF-β;  AOPPs;  Diagnosis;  Comparative study
分类号:
R 544.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.006
文献标志码:
A
摘要:
目的:探讨血清晚期蛋白氧化产物(AOPPs)及转化生长因子β(TGF-β)在高血压肾病的含量以及诊断价值。方法:选择高血压病患者110例作为研究组,其中58例为高血压肾病组,52例为高血压组,另外选取55例健康体检者作为健康对照组。比较三组血清AOPPs及TGF-β的含量变化,并研究AOPPs及TGF-β在高血压肾病中的相关性及诊断价值。结果:与健康对照组相比,高血压组和高血压肾病组患者的血清TGF-β含量均升高,差异有统计学意义(P<0.01); 与健康对照组相比,高血压组患者的血清AOPPs含量无统计学差异(P>0.05),高血压肾病组患者的血清AOPPs含量升高,差异有统计学意义(P<0.01); 与高血压组相比,高血压肾病组患者的血清AOPPs含量升高,差异有统计学意义(P<0.01)。高血压肾病组患者血清TGF-β和AOPPs的含量呈显著正相关(r=0.5162,P<0.01)。结论:血清TGF-β联合AOPPs的检测对高血压肾病具有较高的诊断价值。
Abstract:
Objective:Objective:To investigate the content and diagnostic value of serum AOPPs and TGF-β in hypertensive nephropathy.Methods:110 patients with hypertension were selected as the study group,of which 58 cases were in hypertensive nephropathy group,52 cases were in hypertensive group.55 healthy subjects were selected as healthy control group.The changes of serum AOPPs and TGF-β levels in the three groups were compared,and the correlation and diagnostic value of AOPPs and TGF-β in hypertensive nephropathy were studied.Results:Compared with the healthy control group,the serum TGF-β contents of the hypertension group and the hypertensive nephropathy group were increased(P<0.01).Compared with the healthy control group,the serum AOPPs content of patients in the hypertension group was not statistically different(P>0.05),and the serum AOPPs content of patients in the hypertensive nephropathy group increased(P<0.01).Compared with the hypertension group,the serum AOPPs content of the hypertensive nephropathy group increased(P<0.01).There was a significant positive correlation between serum TGF-β and AOPPs levels in hypertension nephropathy group(r=0.5162,P<0.01).TGF-β combined with AOPPs had higher diagnostic value for hypertensive nephropathy(P<0.01).Conclusion:The detection of serum TGF-β combined with AOPPs has high diagnostic value for hypertensive nephropathy.

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备注/Memo

备注/Memo:
基金项目:陕西省科技厅基金资助项目(2018SF-114); 西安医学院第二附属医院院级课题(19KY0113)
更新日期/Last Update: 2021-01-05