[1]张家伟,华 锋,唐文艳△.血清MMPs及TIMPs检测对神经胶质瘤诊断意义及介入治疗预后判定分析*[J].陕西医学杂志,2020,49(11):1507-1509,1514.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.036]
　ZHANG Jiawei,HUA Feng,TANG Wenyan..Analysis of serum MMPs and TIMPs in the diagnosis of glioma and prognosis of interventional therapy[J].,2020,49(11):1507-1509,1514.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.036]
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血清MMPs及TIMPs检测对神经胶质瘤诊断意义及介入治疗预后判定分析*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年11期
页码:
1507-1509,1514
栏目:
临床检验
出版日期:
2020-11-05

文章信息/Info

Title:
Analysis of serum MMPs and TIMPs in the diagnosis of glioma and prognosis of interventional therapy
作者:
张家伟; 华 锋; 唐文艳△
延安大学咸阳医院神经外科(咸阳712000)
Author(s):
ZHANG Jiawei; HUA Feng; TANG Wenyan.
Department of Neurosurgery,Xianyang Hospital,Yan'an University(Xianyang 712000)
关键词:
基质金属蛋白酶;  血清TIMPs;  抑制剂;  神经胶质瘤;  预后;  临床分期
Keywords:
Metalloproteinase;  Serum TIMPs;  Inhibitor;  Glioma;  Prognosis;  Clinical stage
分类号:
R735.2
DOI:
DOI:10.3969/j.issn.1000-7377.2020.11.036
文献标志码:
A
摘要:
目的:分析血清基质金属蛋白酶(MMPs)及基质金属蛋白酶抑制剂(TIMPs)检测对神经胶质瘤发病的诊断及介入治疗后效果意义,为临床诊断与治疗提供借鉴。方法:收集神经胶质瘤患者220例,比较不同分级神经胶质瘤患者血清中基质金属蛋白酶及其抑制剂水平的变化,同时分析介入治疗后不同MMPs和TIMPs患者的预后情况。并以同期健康体检者为对照组进行对照研究。结果:神经胶质瘤患者血清中MMP1、MMP2、MMP9水平明显升高而TIMP1、TIMP2和TIMP3水平明显降低,且随着肿瘤分期的增高而表达异常明显; 同时,介入治疗后患者血清中MMP2和MMP9与预后呈明显负相关,而TIMP1和TIMP2呈明显正相关。结论:基质金属蛋白酶及其抑制剂是神经胶质瘤临床诊断的重要指标,且与介入治疗后患者的预后密切相关。
Abstract:
Objective:To explore the significance of serum matrix metalloproteinases(MMPs)and tissue inhibitor of metalloproteinase(TIMPs)in the diagnosis of glioma and the effect assessment of interventional therapy.Methods:220 glioma patients were enrolled.The changes in serum levels of MMPs and TIMPs in patients with different grades of glioma were compared.The prognosis of patients with different MMPs and TIMPs after interventional therapy were analyzed.A control study was carried out with healthy subjects as the control group in the same period.Results:The levels of MMP1,MMP2 and MMP9 in the serum of patients with glioma were significantly increased,while the levels of TIMP1,TIMP2 and TIMP3 were significantly reduced,and the expression was abnormally obvious with the increase of tumor stage.At the same time,the serum levels of MMP2 and MMP9 was significantly negatively correlated with prognosis,while TIMP1 and TIMP2 were significantly positively correlated.Conclusion:Matrix metalloproteinases and their inhibitors are important indicators for the clinical diagnosis of glioma,and are closely related to the prognosis of patients after interventional therapy.

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备注/Memo

备注/Memo:
*陕西省咸阳市科技计划项目(2016K02-98)
更新日期/Last Update: 2020-11-05