[1]艾尼瓦尔江·达毛拉,阿布都艾尼·阿不都热合曼,崔自强△.囊内扩大切除术联合静脉滴注唑来膦酸治疗骨巨细胞瘤临床疗效研究*[J].陕西医学杂志,2020,49(11):1396-1398,1402.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.007]
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囊内扩大切除术联合静脉滴注唑来膦酸治疗骨巨细胞瘤临床疗效研究*

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年11期
页码:
1396-1398,1402
栏目:
临床研究
出版日期:
2020-11-05

文章信息/Info

作者:
艾尼瓦尔江·达毛拉1阿布都艾尼·阿不都热合曼2崔自强3△
1.新疆维吾尔自治区人民医院(乌鲁木齐830001); 2.新疆维吾尔自治区喀什市人民医院(喀什844000); 3.陕西省友谊医院(西安710068)
关键词:
骨巨细胞瘤 治疗 囊内扩大切除术 唑来膦酸 无复发生存率
分类号:
R738.1
DOI:
DOI:10.3969/j.issn.1000-7377.2020.11.007
文献标志码:
A
摘要:
目的:评价唑来膦酸作为骨巨细胞术后辅助治疗方法的临床效果。方法:回顾性分析行囊内病灶扩大切除术治疗的骨巨细胞瘤患者47例的临床资料,术后连续静脉滴注唑来膦酸(4 mg、每4周1次、共4次)辅助治疗的患者为唑来膦酸组,术后未进行唑来膦酸静脉注射的患者为对照组,每6个月随访1次,至少随访36个月,随访时进行局部X线及MRI评估肿瘤复发情况,计算局部复发率及无局部复发生存率,记录药物不良反应发生情况并评估唑来膦酸的耐受性。结果:经筛查唑来膦酸组与对照组分别纳入24例、23例患者,唑来膦酸组患者局部复发率为8.3%(2/24)明显低于对照组的13.0%(3/23),两组比较差异有统计学意义(P<0.05); 唑来膦酸组第36个月的无局部复发生存率为(84±8)% 明显高于对照组的(80±4)%,两组比较差异有统计学意义(P<0.05)。唑来膦酸组中16例患者出现了唑来膦酸相关的不良反应,均为一级、二级不良反应,没有患者因不良反应中断治疗。结论:术后静脉使用唑来膦酸辅助治疗可以降低骨巨细胞瘤的局部复发率,虽然大部分患者出现了唑来膦酸相关不良反应,但这并没有导致患者因其中断治疗,患者对其耐受性良好。

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备注/Memo

备注/Memo:
*陕西省社会发展科技攻关项目(2017SF-248)
更新日期/Last Update: 2020-11-05