[1]郑文博,侯 萌△.毛细支气管炎患儿血清维生素D水平与免疫功能指标相关性研究*[J].陕西医学杂志,2020,49(10):1262-1265.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.016]
　ZHENG Wenbo,HOU Meng..Correlation between serum vitamin D level and immune function indexes in children with bronchiolitis[J].,2020,49(10):1262-1265.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.016]
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毛细支气管炎患儿血清维生素D水平与免疫功能指标相关性研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年10期
页码:
1262-1265
栏目:
临床研究
出版日期:
2020-10-05

文章信息/Info

Title:
Correlation between serum vitamin D level and immune function indexes in children with bronchiolitis
作者:
郑文博1; 侯 萌2△
1.陕西中医药大学第二附属医院儿科(咸阳712000); 2.西安惠安医院(西安710302)
Author(s):
ZHENG Wenbo; HOU Meng.
Department of Paediatrics,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine(Xianyang 712000)
关键词:
血清维生素D;  毛细支气管炎;  免疫功能;  免疫球蛋白A;  免疫球蛋白M;  免疫球蛋白G
Keywords:
Serum vitamin D;  Bronchiolitis;  Immune function;  IgA;  IgM;  IgG
分类号:
R725.6
DOI:
DOI:10.3969/j.issn.1000-7377.2020.10.016
文献标志码:
A
摘要:
目的:探讨血清维生素D水平与小儿毛细支气管炎免疫功能指标的相关性。方法:选取收治的120例毛细支气管炎患儿作为观察组,其中将维生素D治疗患儿60例作为观察A组,非维生素D治疗患儿60例作为观察B组,并选取同期治疗的60例支气管肺炎患儿作为对照组; 检测三组患儿血清维生素D水平及免疫球蛋白水平,比较维生素D水平与免疫功能指标之间的相关性。结果:观察组维生素D、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平低于对照组,IgE水平高于对照组,比较差异有统计学意义(P<0.05)。观察A组维生素D、IgA、IgM、IgG水平高于观察B组,IgE水平低于观察B组(P<0.05)。维生素D与IgA、IgG、IgM水平呈正相关性,与IgE水平呈负相关性(P<0.05)。结论:毛细支气管炎患儿血清维生素D水平与免疫球蛋白水平之间具有相关性,补充维生素D,可提高患儿免疫功能,有助于改善临床病症。
Abstract:
Objective:To explore the correlation between serum vitamin D level and immune function indexes in children with bronchiolitis.Methods:A total of 120 children with bronchiolitis were selected as observation group,of which 60 cases treated with vitamin D were selected as observation group 1,and 60 cases treated with non-vitamin D were selected as observation group.60 children with bronchial pneumonia treated in the same period were selected as control group.Serum vitamin D level and immunoglobulin levels of three groups were detected,and the correlation between vitamin D level and immune function indexes was compared.Results:The levels of vitamin D,IgA,IgM and IgG in the observation group were lower than those in the control group,and the level of IgE was higher than that in the control group(P<0.05).The levels of vitamin D,IgA,IgM and IgG in observation group 1 were higher than those in observation group 2,and the level of IgE was lower than that in observation group 2(P<0.05).Vitamin D was positively correlated with IgA,IgG and IgM levels,and negatively correlated with IgE level,and the difference was statistically significant(P<0.05).Conclusion:There is a correlation between serum vitamin D level and immunoglobulin levels in children with bronchiolitis.Vitamin D supplementation can improve children's immune function and help to improve clinical symptoms.

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备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(BS2015YY030)
更新日期/Last Update: 2020-10-10