[1]李春燕,刘 燕△.内镜下止血联合不同剂量生长抑素治疗消化性溃疡出血的疗效及其对胃肠功能的影响[J].陕西医学杂志,2020,49(9):1165-1167，1171.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.028]
　LI Chunyan,LIU Yan..Curative effect of endoscopic hemostasis combined with different doses of somatostatin on peptic ulcer bleeding and its influence on gastrointestinal function[J].,2020,49(9):1165-1167，1171.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.028]
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内镜下止血联合不同剂量生长抑素治疗消化性溃疡出血的疗效及其对胃肠功能的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年9期
页码:
1165-1167，1171
栏目:
药物与临床
出版日期:
2020-09-01

文章信息/Info

Title:
Curative effect of endoscopic hemostasis combined with different doses of somatostatin on peptic ulcer bleeding and its influence on gastrointestinal function
作者:
李春燕1; 刘 燕2△
1.解放军联勤保障部队第987医院消化内科(宝鸡 721000); 2.西安市长安区中医医院消化内科(西安710100)
Author(s):
LI Chunyan; LIU Yan.
Department of Gastroenterology,the 987th Hospital of the PLA Joint Logistic Support Force(Baoji 721000)
关键词:
内镜下止血;  不同剂量;  生长抑素;  消化性溃疡出血;  疗效;  胃肠功能
Keywords:
Endoscopic hemostasis;  Different dose;  Somatostatin;  Peptic ulcer bleeding;  Curative effect;  Gastrointestinal function
分类号:
R573.1
DOI:
DOI:10.3969/j.issn.1000-7377.2020.09.028
文献标志码:
A
摘要:
目的:探讨内镜下止血联合不同剂量生长抑素对消化性溃疡出血的疗效及胃肠功能影响。方法:选取80例消化性溃疡出血患者,随机分为研究组和对照组,每组40例。研究组采取内镜下止血联合大剂量生长抑素治疗,对照组采取内镜下止血联合小剂量生长抑素治疗。对比不同剂量生长抑素对消化性溃疡出血的疗效及对胃肠功能的影响。结果:两组患者治疗前胃泌素、生长抑素及胃动素水平比较,差异无统计学意义(P>0.05),治疗后研究组均明显低于对照组(P<0.05)。两组患者治疗前TGF-α、IL-6、CRP水平比较无统计学差异(P>0.05),治疗后研究组CRP、IL-6水平低于对照组,TGF-α水平高于对照组(均P<0.05)。研究组治疗总有效率明显高于对照组(P<0.05)。结论:内镜下止血联合大剂量生长抑素治疗消化性溃疡出血疗效显著,可改善患者的临床症状,在促进患者胃肠功能恢复、创面修复和降低炎性因子水平方面效果更明显。
Abstract:
Objective:To explore the curative effect of endoscopic hemostasis combined with different doses of somatostatin on peptic ulcer bleeding and its influence on gastrointestinal function.Methods:Eighty patients with peptic ulcer bleeding were randomly divided into control group and study group,40 cases each.The study group was treated with endoscopic hemostasis combined with high dose of somatostatin,while the control group was treated with endoscopic hemostasis combined with low dose of somatostatin.The curative effect of different doses of somatostatin on peptic ulcer bleeding and its influence on gastrointestinal function.Results:The levels of gastrin,somatostatin and motilin before treatment in the two groups were not statistically significant(P>0.05).After treatment,the levels of the three indexes in the study group was significantly lower than those in the control group(P<0.05).The levels of TGF-α,IL-6 and CRP before treatment in the two groups were not statistically different(P>0.05).After treatment,the levels of IL-6 and CRP in the study group were lower than those in the control group(P<0.05),and The level of TGF-α was significantly higher than that in the control group(P<0.05).The total effective rate of the study group was significantly higher than that of the control group(P<0.05).Conclusion:Endoscopic hemostasis combined with high-dose somatostatin has significant curative effect in the treatment of peptic ulcer bleeding,which can improve the clinical symptoms of patients,and is more effective in promoting gastrointestinal function recovery,wound repair and reducing inflammatory factor levels.

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更新日期/Last Update: 2020-09-02