[1]刘玲娇,李 婧,闫 妮,等.健康体检职业人群中同型半胱氨酸水平影响因素分析*[J].陕西医学杂志,2020,49(9):1082-1084.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.007]
　LIU Lingjiao,LI Jing,YAN Ni,et al.Influencing factors of homocysteine level in occupational population[J].,2020,49(9):1082-1084.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.007]
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健康体检职业人群中同型半胱氨酸水平影响因素分析*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年9期
页码:
1082-1084
栏目:
临床研究
出版日期:
2020-09-01

文章信息/Info

Title:
Influencing factors of homocysteine level in occupational population
作者:
刘玲娇1; 李 婧1; 闫 妮1; 汶 倩2△
1.陕西省人民医院内分泌代谢科(西安710068); 2.西安交通大学附属西安市第九医院体检中心(西安710054)
Author(s):
LIU Lingjiao; LI Jing; YAN Ni; et al.
Department of Endocrinology and Metabolism,Shaanxi Provincial People's Hospital(Xi'an 710068)
关键词:
同型半胱氨酸;  血脂;  尿酸;  职业人群;  健康体检;  危险因素
Keywords:
Homocysteine;  Blood lipid;  Uric acid;  Occupation population;  Health examination;  Risk factors
分类号:
R541.4
DOI:
DOI:10.3969/j.issn.1000-7377.2020.09.007
文献标志码:
A
摘要:
目的:调查西安市健康体检人群中血同型半胱氨酸(Hcy)的影响因素,为高同型半胱氨酸血症(HHcy)的防治提供参考依据。方法:共纳入健康体检职业人群资料738例,收集其一般信息并检测其血清Hcy水平及生化指标,分析HHcy人群的特点以及Hcy水平的影响因素。结果:738例研究对象年龄28～60岁,其中Hcy正常组551例,HHcy组187例,HHcy检出率为25.3%; 与Hcy正常组相比,HHcy组男性比例、吸烟及饮酒人群比例、体质量指数(BMI)、腰围、甘油三酯(TG)、尿酸(UA)较高,高密度脂蛋白胆固醇(HDL-C)较低,组间差异有统计学意义(均P<0.05)。对Hcy影响因素的多元逐步回归分析结果显示,最终进入回归方程的有性别、HDL-C和UA。结论:西安市职业人群HHcy具有较高的检出率,其中男性、高尿酸水平以及低HDL-C水平是HHcy的独立危险因素。
Abstract:
Objective:To investigate the factors affecting homocysteine(Hcy)level in healthy occupational people in Xi'an City,and to provide reference for the prevention and treatment of hyperhomocysteinemia(HHcy).Methods:A total of 738 occupational cases taking health examination were included.Their general information were collected,and the levels of serum Hcy and biochemical indicators were detected,and the characteristics of their HHcy population and the influencing factors of Hcy level were analyzed.Results:738 subjects were aged from 28 to 60 years,including 551 cases in the Hcy normal group and 187 cases in the HHcy group.The detection rate of HHcy was 25.3%.Compared with the Hcy normal group,the proportion of male,the proportion of people smoking and drinking,body mass index(BMI),waist circumference,triglyceride(TG)and uric acid(UA)were higher,and HDL-C was lower in the HHcy group,and the differences between the two groups were statistically significant(all P<0.05).The results of multiple stepwise regression analysis of the possible factors influencing Hcy showed that gender,HDL-C and UA finally entered the regression equation.Conclusion:There was a high detection rate of HHcy in the occupational population in Xi'an,among which male,high UA level and low HDL-C level are independent risk factors of HHcy.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目(81700735)
更新日期/Last Update: 2020-09-02