[1]庞芳宁,白 槟,杨 鹏,等.肿瘤标志物CEA、CA199、CA125联合检测对胃癌筛查价值及与TNM分期的关系*[J].陕西医学杂志,2020,49(8):1040.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.032]
　PANG Fangning,BAI Bin,YANG Peng,et al.Screening value of combined detection of tumor markers CEA,CA199 and CA125 in gastric cancer and its relationship with TNM stage[J].,2020,49(8):1040.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.032]
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肿瘤标志物CEA、CA199、CA125联合检测对胃癌筛查价值及与TNM分期的关系*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年8期
页码:
1040
栏目:
临床检验
出版日期:
2020-08-05

文章信息/Info

Title:
Screening value of combined detection of tumor markers CEA,CA199 and CA125 in gastric cancer and its relationship with TNM stage
作者:
庞芳宁1; 白 槟2; 杨 鹏1; 赵青川2△; 蒋金泉1
1.西安国际医学中心医院消化外科(西安 710100); 2.空军军医大学西京医院(西安 710032)
Author(s):
PANG Fangning; BAI Bin; YANG Peng; et al.
Digestive Surgery,Xi'an International Medical Center Hospital(Xi'an 710100)
关键词:
胃癌;  诊断;  肿瘤标志物;  TNM分期;  肿瘤大小;  性别;  年龄
Keywords:
Gastric cancer;  Diagnosis;  Tumor markers;  TNM staging;  Tumor size;  Gender;  Age
分类号:
R735.2
DOI:
DOI:10.3969/j.issn.1000-7377.2020.08.032
文献标志码:
A
摘要:
目的:探讨肿瘤标志物CEA、CA199、CA125联合检测对胃癌的筛查价值及与肿瘤大小、性别、年龄、TNM分期的关系。方法:收集病理诊断为胃癌的患者3807例。观察不同TNM分期中,患者CEA、CA199、CA125、肿瘤大小、性别及年龄的差异。结果:CEA、CA199及CA125的测量值在胃癌四个分期间的比较均有统计学差异(P<0.05)。其中CEA、CA199两种标志物在TNM分期I期时均值低于标准值,CEA在胃癌处于Ⅱ 、Ⅲ 、Ⅳ期时均值明显增高。CA199在Ⅱ 、Ⅲ期时均值略升高,在Ⅳ期时均值增高明显。CA125在I、Ⅱ 、Ⅲ、Ⅳ期时均值均低于标准值。所有分期中男性比例高于女性。年龄≤60岁与>60岁组间比较差异有统计学意义(P<0.05),肿瘤≤5 cm与肿瘤>5 cm组间比较差异有统计学意义(P<0.05)。结论:CEA、CA199两种肿瘤标志物对I期胃癌的筛查阳性率低。CEA在胃癌处于Ⅱ、Ⅲ、Ⅳ期时筛查阳性率较高,CA199在Ⅳ期时阳性率高,具有较好的筛查意义。CA125对胃癌诊断的筛查阳性率低。术前检测CEA、CA199、CA125三种肿瘤标志物,在确诊胃癌患者中至少有一项阳性的占总例数的34.3%,对胃癌诊断具有提示作用。
Abstract:
Objective:To explore the screening value of CEA,CA199 and CA125 in gastric cancer and their relationship with tumor size,gender,age and TNM stage.Methods:A total of 3807 patients with pathological diagnosis of gastric cancer were collected.The differences of CEA,CA199,CA125,tumor size,gender and age were observed in different TNM stages.Results:The measurement values of CEA,CA199 and CA125 were statistically different in the four stages of gastric cancer(P<0.05).Among them,the mean value of CEA and CA199 in TNM stage Ⅰ was lower than the standard value,and the mean value of CEA was significantly higher in stage Ⅱ,Ⅲ and Ⅳ.The mean value of CA199 increased slightly in stage Ⅱ and Ⅲ,and increased significantly in stage Ⅳ.The mean value of CA125 in stageⅠ,Ⅱ,Ⅲ and Ⅳ was lower than the standard value.The proportion of male in all stages was higher than that of female.The difference between the age group ≤60 and >60 years old was statistically significant(P<0.05),and the difference between the tumor ≤ 5 cm and the tumor > 5 cm was statistically significant(P<0.05).Conclusion:CEA and CA199 have a low screening positive rate for stageⅠ gastric cancer.CEA has a higher screening positive rate when gastric cancer is in stageⅡ,Ⅲ and Ⅳ,and CA199 has a higher positive rate in stage Ⅳ,which has better screening significance.The positive rate of CA125 screening for gastric cancer diagnosis is low.Preoperative detection of CEA,CA199 and CA125,at least one positive in patients with confirmed gastric cancer accounted for 34.3%,which has a suggestive role in the diagnosis of gastric cancer.

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备注/Memo

备注/Memo:
*国家重点研发计划项目子课题(2017YFC1311002,2017YFC1311004)
更新日期/Last Update: 2020-08-04