[1]祝景伟,佟经伟,许培权△.Hippo信号通路中TAZ、YAP在三阴性乳腺癌中的表达及意义[J].陕西医学杂志,2020,49(8):940-943968.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.007]
　ZHU Jingwei,TONG Jingwei,XU Peiquan..Expression and significance of TAZ and YAP in Hippo signaling pathway in triple negative breast cancer[J].,2020,49(8):940-943968.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.007]
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Hippo信号通路中TAZ、YAP在三阴性乳腺癌中的表达及意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年8期
页码:
940-943968
栏目:
基础研究
出版日期:
2020-08-05

文章信息/Info

Title:
Expression and significance of TAZ and YAP in Hippo signaling pathway in triple negative breast cancer
作者:
祝景伟; 佟经伟; 许培权△
蚌埠医学院第一附属医院(蚌埠 233004)
Author(s):
ZHU Jingwei; TONG Jingwei; XU Peiquan.
The First Affiliated Hospital of Bengbu Medical College(Bengbu 233004)
关键词:
三阴性乳腺癌;  Hippo信号通路;  具有PDZ结合基序的转录共活化蛋白;  Yes相关蛋白;  免疫组化;  临床病理特征
Keywords:
Triple negative breast cancer;  Hippo signaling pathway;  Transcriptional co-activator with PDZ-binding motif;  Yes-associated protein;  Immunohistochemisty;  Clinicopathological features
分类号:
R737.9
DOI:
DOI:10.3969/j.issn.1000-7377.2020.08.007
文献标志码:
A
摘要:
目的:检测Hippo信号通路核心下游转录调控分子具有PDZ结合基序的转录共活化蛋白(TAZ)和Yes相关蛋白(YAP)在三阴性乳腺癌组织中的表达,探讨其与三阴性乳腺癌患者临床病理特征的关系。方法:收集病理确诊的浸润性乳腺癌患者60例(三阴性乳腺癌30例,非三阴性乳腺癌30例),应用免疫组织化学方法检测60例乳腺癌组织中TAZ和YAP的表达情况,并分析其与三阴性乳腺癌患者的年龄、肿瘤大小、淋巴结转移、TNM分期及组织学分级等的关系。结果:TAZ、YAP在三阴性乳腺癌组织中的表达显著高于非三阴性乳腺癌组织(P<0.05); TAZ和YAP的表达与三阴性乳腺癌的肿瘤大小、组织学分级相关(P<0.05),而与年龄、淋巴结转移、TNM分期无关; 在三阴性乳腺癌中,TAZ与YAP的表达呈正相关(r=0.537,P<0.05)。结论:Hippo信号通路参与了三阴性乳腺癌的发生发展。
Abstract:
Objective:To detect the expression levels of transcriptional co-activator with PDZ-binding motif(TAZ)and yes-associated protein(YAP)in Hippo signaling pathway in triple negative breast cancer tissues,and to explore the relationship between them and the clinicopathological characteristics of triple negative breast cancer patients.Methods:Sixty patients with invasive breast cancer confirmed by pathological diagnosis(30 cases of triple negative breast cancer and 30 cases of non triple negative breast cancer)were enrolled.The expression levels of TAZ and YAP in breast cancer tissue was detected by immunohistochemical method,and the relationship between them and age,tumor size,lymph node metastasis,TNM stage and histological grade of triple negative breast cancer patients was analyzed.Results:The expression levels of TAZ and YAP in triple negative breast cancer tissues were significantly higher than those in non triple negative breast cancer tissues(P<0.05).The expression levels of TAZ and YAP were correlated with tumor size and histological grade(P<0.05),but not with age,lymph node metastasis and TNM stage.In triple negative breast cancer,the expression level of TAZ was positively correlated with that of YAP(r=0.537,P<0.05).Conclusion:Hippo signaling pathway may be involved in the development of triple negative breast cancer.

参考文献/References:

[1] Zanconato F,Cordenonsi M,Piccolo S.YAP/TAZ at the roots of cancer[J].Cancer Cell,2016,29(6):783-803.
[2] 白婧如,赵秀兰,孙 冉,等.TAZ促进胃癌中血管生成及相关机制的研究[J].中国肿瘤临床,2019,46(6):272-277.
[3] 齐海霞,柴艳芬.Hippo信号通路相关分子与肿瘤发生的研究进展[J].医学综述,2020,26(4):683-689.
[4] 邵伟华,李 晋,龚炜韬,等.Hippo-TAZ/YAP信号通路在头颈部鳞状细胞癌中的研究进展[J].口腔医学,2020,40(1):71-77.
[5] Guo P,Kang S,Zhao F.High expression of TAZ/YAP promotes the progression of malignant melanoma and affects the postoperative survival of patients[J].Pharmazie,2018,73(11):662-665.
[6] Wang S,Ma K,Chen L,et al.TAZ promotes cell growth and inhibits Celastrol-induced cell apoptosis[J].Bioscience Reports,2016,36(5):e00386-e00386.
[7] Maud D,Sanchez-Danes A,Sandrine R,et al.YAP and TAZ are essential for basal and squamous cell carcinoma initiation[J].Embo Reports,2018,19(7):e45809.
[8] 陈 鹏,赵景岚,鲁瑞珍,等.非小细胞肺癌组织中TAZ、YAP蛋白表达变化及意义[J].山东医药,2018,58(21):61-63.
[9] 涂敏松,李逸松,张 雄.YAP、TAZ蛋白在口腔鳞状细胞癌中的表达及意义[J].上海口腔医学,2018,27(4):415-418.
[10] 张改华,杜文英.乳腺癌151例分子亚型临床与病理特点[J].陕西医学杂志,2014,43(7):909-911.
[11] 王士娜,唐 玮,金 丹,等.三阴性乳腺癌(TNBC)患者的临床病理特点及预后分析[J].中国医药指南,2019,17(26):90-91.
[12] Justice RW,Zilian O,Woods DF,et al.The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation[J].Genes & Development,1995,9(5):534-546.
[13] Xu T,Wang W,Zhang S,et al.Identifying tumor suppressors in genetic mosaics:the Drosophila lats gene encodes a putative protein kinase[J].Development,1995,121(4):1053-1063.
[14] 徐声铭,吴 靖,张志愿.YAP/TAZ在肿瘤微环境中的研究进展[J].现代肿瘤医学,2019,27(19):3539-3542.
[15] Lei QY,Zhang H,Zhao B,et al.TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway[J].Mol Cell Biol,2008,28(7):2426-2436.
[16] Liu CY,Zha ZY,Zhou X,et al.The Hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF β-TrCP,E3 ligase[J].Journal of Biological Chemistry,2010,285(48):37159-37169.
[17] 宋经略,崔 龙.转录因子TEAD4在肿瘤发生发展及治疗中的作用[J].中国肿瘤生物治疗杂志,2019,26(7):817-822.
[18] 周 宁,郭纪伟,代娟娟,等.YAP对非小细胞肺癌细胞增殖和迁移能力的影响[J].吉林大学学报:医学版,2019,45(6):1320-1326.
[19] Hsu PC,You B,Yang YL,et al.YAP promotes erlotinib resistance in human non-small cell ling cancer cells[J].Oncotarget,2016,7(32):51922-51933.
[20] Lai D,Ho KC,Hao Y,et al.Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF[J].Cancer Res,2011,71(7):2728-2738.

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更新日期/Last Update: 2020-08-04