[1]赵新春,张 翔△.利伐沙班治疗急性肺血栓栓塞疗效及对患者血生化指标、右心室功能的影响研究[J].陕西医学杂志,2020,49(7):874-877880.[doi:DOI:10.3969/j.issn.10007377.2020.07.029]
　ZHAO Xinchun,ZHANG Xiang..Effect of rivaroxaban in treatment of acute pulmonary thromboembolism and its influence on blood biochemical indexes and right ventricular function[J].,2020,49(7):874-877880.[doi:DOI:10.3969/j.issn.10007377.2020.07.029]
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利伐沙班治疗急性肺血栓栓塞疗效及对患者血生化指标、右心室功能的影响研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年7期
页码:
874-877880
栏目:
药物与临床
出版日期:
2020-07-05

文章信息/Info

Title:
Effect of rivaroxaban in treatment of acute pulmonary thromboembolism and its influence on blood biochemical indexes and right ventricular function
作者:
赵新春1 ; 张 翔2△
1.空军军医大学第一附属医院急诊科(西安710032); 2.武警第一机动总队直升机支队乌鲁木齐场站卫生队(乌鲁木齐 830017)
Author(s):
ZHAO Xinchun; ZHANG Xiang.
Department of Emergency,the First Affiliated Hospital of Air Force Military Medical University(Xi'an 710032)
关键词:
利伐沙班;  急性肺血栓栓塞;  肿瘤坏死因子-α;  C-反应蛋白;  白介素-10;  Tei指数;  右心室功能
Keywords:
Rivaroxaban;  Acute pulmonary thromboembolism;  TNF-α;  CRP;  IL-10;  Tei index;  Right ventricular function
分类号:
R563
DOI:
DOI:10.3969/j.issn.10007377.2020.07.029
文献标志码:
A
摘要:
目的:探讨口服抗凝药利伐沙班对急性肺血栓栓塞(APTE)患者血生化指标及右心室功能的影响。方法: 选取102例APTE患者作为研究对象,随机分为观察组(51例)和对照组(51例)。其中对照组和观察组分别口服华法林和利伐沙班进行6个月抗凝治疗,比较两组患者治疗前后血生化指标:肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白介素-10(IL-10)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、一氧化氮(NO)、D-二聚体(D-D)、内皮素-1(ET-1)和右心室功能指标:血浆N终端脑钠肽(NT-pro BNP)、右心室/左心室舒张期横径比值(RVDD/LVDD)、肺动脉收缩压(SPAP)、右心室面积变化分数(RVFAC)、右心室游离壁三尖瓣环收缩期位移(TAPSE)和右心室Tei指数,以及治疗的有效率和治疗期间不良反应发生率。结果:治疗后,观察组患者的TNF-α、CRP和IL-10均明显低于治疗前(P<0.05),且观察组患者的TNF-α、CRP和IL-10均明显低于对照组(P<0.05); 两组患者的PT、APTT、NO、RVFAC和TAPSE均明显高于治疗前(P<0.05),D-D、ET-1、NT-pro BNP、RVDD/LVDD、SPAP和Tei指数比对照组明显降低(P<0.05); 观察组治疗有效率比对照组升高(P<0.05); 治疗期间,观察组不良反应发生率比对照组降低(P<0.05)。结论:相比华法林,口服利伐沙班进行抗凝治疗能有效减轻APTE患者炎症反应,改善血管内皮功能和右心室功能,具有更高的治疗疗效和安全性。
Abstract:
Objective:To explore the effect of rivaroxaban in treatment of acute pulmonary thromboembolism(APTE)and its influence on blood biochemical indexes and right ventricular function. Methods:102 APTE patients were enrolled as study objects and randomly divided into observation group(51 cases)and control group(51 cases). The control group and observation group were given oral warfarin and rivaroxaban for 6-month anticoagulant therapy,respectively. The serum biochemical indexes(TNF-α,CRP,IL-10,PT,APTT,NO,D-D,ET-1),right ventricular function indexes(NT-pro BNP,RVDD/LVDD,SPAP,RVFAC,TAPSE),Tei index,as well as the effective rate and incidence of adverse reactions were compared between the two groups. Results:After treatment,the levels of TNF-α,CRP and IL-10 in observation group were significantly decreased(P<0.05),and which were significantly lower than those in control group(P<0.05); the PT,APTT,NO,RVFAC and TAPSE of both groups were significantly increased(P<0.05),while the D-D,ET-1,NT-pro BNP,RVDD/LVDD,SPAP and Tei index were significantly decreased(P<0.05); PT,APTT,NO,RVFAC and TAPSE in observation group were significantly higher than those in control group(P<0.05),while D-D,ET-1,NT-pro BNP,RVDD/LVDD,SPAP and Tei index were significantly lower than those in control group(P<0.05); the effective rate of treatment in observation group was higher than that in control group(P<0.05),while the incidence of adverse reactions was lower than that in control group(P<0.05). Conclusion:Compared with warfarin,oral rivaroxaban for anticoagulant therapy can effectively alleviate in-flammatory response of APTE patients,improve vascular endothelial function and right ventricular function,which is of higher curative effect and safety.

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更新日期/Last Update: 2020-07-28