[1]武卫党,石 磊,张丹凤△,等.达格列净对糖尿病心肌缺血大鼠心肌功能改善作用的实验研究*[J].陕西医学杂志,2020,49(7):778-780.[doi:DOI:10.3969/j.issn.10007377.2020.07.003]
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达格列净对糖尿病心肌缺血大鼠心肌功能改善作用的实验研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年7期
页码:
778-780
栏目:
基础研究
出版日期:
2020-07-05

文章信息/Info

作者:
武卫党1石 磊2张丹凤1△徐晓辉1耿蓬勃1赵蓓蕾1陈文璐1郭小雪1
1.西电集团医院心内科(西安710077); 2.空军军医大学第二附属医院药剂科(西安 710038)
关键词:
达格列净 糖尿病 心肌缺血 一氧化氮 血管内皮细胞 血液流变学
分类号:
R587.1
DOI:
DOI:10.3969/j.issn.10007377.2020.07.003
文献标志码:
A
摘要:
目的:考察达格列净对糖尿病合并心肌缺血大鼠心肌及血液流变学的改善作用。方法:采用Wistar大鼠建立高脂饮食及链脲佐菌素诱导的2型糖尿病模型在该模型基础上建立心肌缺血大鼠模型,检测大鼠血糖、糖化血红蛋白含量,血清一氧化氮(NO)、一氧化氮合酶(NOS)及血浆内皮素(ET)含量,血流变相关指标及心室质量/体质量,心肌中乳酸脱氢酶及血管紧张素Ⅱ含量,考察达格列净对以上指标的影响。结果:模型大鼠血糖、糖化血红蛋白含量显著升高,血清NO、NOS指标显著降低,血浆ET 含量明显升高与正常组具有统计学差异(P<0.05); 大鼠血液流变学指标显著改变,心室质量/体质量明显升高,心肌中乳酸脱氢酶及血管紧张素Ⅱ含量显著升高。给予达格列净干预后,大鼠血糖、糖化血红蛋白含量明显降低,血管功能相关因子NO 、NOS 及血浆ET 含量显著恢复与模型组具有统计学差异; 大鼠血液流变学指标显著恢复,心室质量/体质量,心肌中乳酸脱氢酶及血管紧张素Ⅱ含量指标明显改善。结论:达格列净对糖尿病心肌缺血大鼠心肌功能具有显著改善作用,可明显恢复糖尿病心肌缺血大鼠心肌及血管相关功能。

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备注/Memo

备注/Memo:
*陕西省重点研发计划项目(2018SF-288)
更新日期/Last Update: 2020-07-28