[1]刘鹏程,罗有才,纪文军,等.立体定向-改良软通道微创介入颅内血肿清除术对高血压脑出血患者血清NSE、S100B、炎症因子水平及预后的影响[J].陕西医学杂志,2020,49(3):321-324,328.
　LIU Pengcheng,LUO Youcai,JI Wenjun,et al.Effects of stereoscopic orientation-modified soft-channel minimally invasive intervention intracranial hematoma evacuation on serum NSE,S100B,inflammatory factor levels and prognosis in patients with hypertensive intracerebral hemorrhage[J].,2020,49(3):321-324,328.
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立体定向-改良软通道微创介入颅内血肿清除术对高血压脑出血患者血清NSE、S100B、炎症因子水平及预后的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年3期
页码:
321-324,328
栏目:
临床研究
出版日期:
2020-03-05

文章信息/Info

Title:
Effects of stereoscopic orientation-modified soft-channel minimally invasive intervention intracranial hematoma evacuation on serum NSE,S100B,inflammatory factor levels and prognosis in patients with hypertensive intracerebral hemorrhage
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2020.03.015
作者:
刘鹏程1; 罗有才1; 纪文军1; 马小红1; 史晓艳2
1.陕西省榆林市第二医院神经外科(榆林 719000); 2.陕西省榆林市榆阳区人民医院(陕西省榆林市儿童医院)检验科(榆林 719000)
Author(s):
LIU Pengcheng; LUO Youcai; JI Wenjun; et al.
Department of Neurosurgery,Yulin NO.2 Hospital,Shaanxi Province(Yulin 719000)
关键词:
高血压脑出血;  微创;  神经元特异性烯醇化酶;  S100B;  炎症因子;  颅内血肿清除术
Keywords:
Hypertensive intracerebral hemorrhage;  Minimally invasive;  Neuron specific enolase;  S100B;  Inflammatory factor;  Removal of intracranial hematoma
分类号:
R651.1
文献标志码:
A
摘要:
目的:探讨立体定向-改良软通道微创介入颅内血肿清除术对高血压脑出血患者(HICH)血清NSE、S100B、炎症因子水平及预后的影响。方法:选取HICH患者55例,依据手术方式的不同分为观察组29例、对照组26例。观察组行立体定向-改良软通道微创介入颅内血肿清除术; 对照组行硬通道颅内血肿清除术。观察、记录两组患者的手术情况,包括术中出血量、手术时间、血肿引流时间及住院时间; 于患者治疗前、治疗后7d、治疗后14d进行NIHSS评分; 计算两组患者治疗后的血肿清除率、并发症发生率; ELISA法检测两组患者治疗前后NSE、S100B、IL-6水平; 并以ADL评分分级法评估患者预后情况。结果:观察组的手术时间、血肿引流时间及住院时间显著低于对照组; 与治疗前相比,两组患者治疗后7d、治疗后14d的NIHSS评分均显著降低(P<0.05),且观察组的NIHSS评分明显低于对照组(P<0.05); 治疗后,观察组患者的血肿清除率为(82.47±6.81)%,并发症发生率为6.90%,均显著优于对照组的血肿清除率(65.47±6.77)%及并发症发生率26.92%(P<0.05); 治疗后,两组患者的血清NSE、S100B、IL-6水平均显著降低(P<0.05),且观察组患者的血清NSE、S100B、IL-6水平更低(P<0.05); 观察组的预后良好率(89.66%)显著高于对照组的(61.54%)(P<0.05)。结论:对HICH患者行立体定向-改良软通道微创介入颅内血肿清除术疗效确切,可有效降低血清NSE、S100B、炎症因子水平,改善患者预后。
Abstract:
Objective:To explore the effects of stereoscopic orientation-modified soft-channel minimally invasive intervention intracranial hematoma evacuation on serum NSE,S100B,inflammatory factor levels and prognosis in patients with hypertensive intracerebral hemorrhage(HICH).Methods:A total of 55 patients with HICH were enrolled.According to different surgical methods,they were divided into observation group(29 cases)and control group(26 cases).The observation group was treated with stereoscopic orientation-modified soft-channel minimally invasive intervention intracranial hematoma evacuation,while the control group was treated with hard channel intracranial hematoma evacuation.The operation conditions of the two groups were observed and recorded,including intraoperative blood loss,operation time,hematoma drainage time and hospitalization time.NIHSS scores were performed before treatment,and on 7th day and 14th day after treatment.The hematoma clearance rate and incidence rate of complications were recorded in both groups after treatment.ELISA method was performed to detect levels of NSE,S100B and IL-6 in both groups before and after treatment.The prognosis of patients was evaluated by ADL scoring grading.Results:The operation time,hematoma drainage time and hospitalization time of observation group were significantly lower than those of control group.Compared with NIHSS scores before treatment,those of the two groups on 7th day and 14th day after treatment were significantly decreased(P<0.05).The NIHSS scores of observation group were significantly lower than those of control group(P<0.05).After treatment,hematoma clearance rate [(82.47±6.81)%] and incidence rate of complications(6.90%)in observation group were significantly better than those in control group [(65.47±6.77)%,26.92%](P<0.05).After treatment,the levels of serum NSE,S100B and IL-6 in both groups were significantly decreased(P<0.05),and the above indexes in observation group were lower(P<0.05).The good prognosis rate of observation group(89.66%)was significantly higher than that of control group(61.54%)(P<0.05).Conclusion:The curative effect of stereoscopic orientation-modified soft-channel minimally invasive intervention intracranial hematoma evacuation is significant on HICH patients,which can effectively reduce the levels of serum NSE,S100B and inflammatory factors,and improve the prognosis of patients.

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更新日期/Last Update: 2020-03-25