[1]姜 萌,赵 鹏△.奥曲肽联合加贝酯治疗重症急性胰腺炎疗效及对患者血清细胞因子水平的影响[J].陕西医学杂志,2020,49(2):212-215.
　JIANG Meng,ZHAO Peng..Clinical efficacy of octreotide combined with gabexate in the treatment of severe acute pancreatitis and its effect on serum cytokine levels[J].,2020,49(2):212-215.
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奥曲肽联合加贝酯治疗重症急性胰腺炎疗效及对患者血清细胞因子水平的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年2期
页码:
212-215
栏目:
药物与临床
出版日期:
2020-02-05

文章信息/Info

Title:
Clinical efficacy of octreotide combined with gabexate in the treatment of severe acute pancreatitis and its effect on serum cytokine levels
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2020.02.023
作者:
姜 萌; 赵 鹏△
陕西省铜川市人民医院(铜川 727100)
Author(s):
JIANG Meng; ZHAO Peng.
Tongchuan People's Hospital in Shaanxi Province(Tongchuan 727100)
关键词:
急性胰腺炎;  治疗;  奥曲肽;  加贝酯;  炎症反应;  肠道黏膜屏障
Keywords:
Acute pancreatitis;  Therapy;  Octreotide;  Gabexate;  Inflammatory response;  Intestinal mucosal barrier
分类号:
R657.51
文献标志码:
A
摘要:
目的:探讨奥曲肽联合加贝酯治疗急性胰腺炎的临床疗效及患者血清细胞因子水平的变化。方法:118例重症急性胰腺炎患者随机分成两组,每组各59例,对照组静脉持续泵入奥曲肽治疗,观察组在对照组基础上联合加贝酯治疗,治疗7 d后比较两组患者临床症状改善情况、临床疗效、血清炎症因子水平及肠黏膜通透性的变化。结果:观察组患者治疗后APACHEⅡ评分及腹内压均低于对照组,且腹痛缓解时间、排便恢复时间及ICU住院时间较对照组明显缩短(P<0.05); 治疗后观察组临床总有效率为89.83%明显高于对照组的66.10%,两组比较差异有统计学意义(P<0.05); 治疗后两组患者血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)水平均显著降低(P<0.05),且治疗后观察组各指标水平均明显低于同期对照组(P<0.05); 治疗后两组患者血二胺氧化酶(DAO)及尿乳果糖/甘露醇(L/M)比值均明显降低(P<0.05),且观察组各指标降低幅度大于对照组(P<0.05)。结论:奥曲肽联合加贝酯治疗重症急性胰腺炎能明显改善患者临床症状、减轻炎症反应,并能促进肠道黏膜屏障的修复。
Abstract:
Objective:To investigate the clinical efficacy of octreotide combined with gabexate in the treatment of acute pancreatitis and the changes of serum cytokines.Methods:118 patients with severe acute pancreatitis were randomly divided into two groups,59 cases in each group.The control group was continuously treated with octreotide intravenously.The observation group was treated with gabecate on the basis of the control group.After 7 days of treatment,the clinical symptoms,clinical efficacy,serum inflammatory factor levels and intestinal mucosal permeability were compared between the two groups.Results:The APACHE II score and intra-abdominal pressure were lower in the observation group than those in the control group.The abdominal pain relief time,bowel movement recovery time and hospitalization time in ICU were significantly shorter in the observation group than those in the control group(P<0.05).After treatment,the total effective rate of the observation group was 89.83%,which was significantly higher than that of the control group(66.10%).The difference between the two groups was statistically significant(P<0.05).Serum levels of TNF-α,IL-6,CRP and PCT were significantly lower in the two groups(P<0.05),and the levels of the indicators in the observation group were significantly lower than those in the control group(P<0.05).The blood DAO level and urine L/M ratio of the two groups were significantly lower(P<0.05),and the decrease of each index in the observation group was greater than that in the control group(P<0.05).Conclusion:Octreotide combined with gabexate in the treatment of severe acute pancreatitis can significantly improve the clinical symptoms,reduce the inflammatory response,and promote the repair of intestinal mucosal barrier.

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更新日期/Last Update: 2020-03-25