[1]王 磊,高 明,刘 项,等.不同来源精子治疗完全性弱精子症妊娠结局研究*[J].陕西医学杂志,2020,49(2):148-150,161.
　WANG Lei,GAO Ming,LIU Xiang,et al.Study on pregnancy outcome of complete asthenospermia treated with different sperm sources[J].,2020,49(2):148-150,161.
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不同来源精子治疗完全性弱精子症妊娠结局研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年2期
页码:
148-150,161
栏目:
临床研究
出版日期:
2020-02-05

文章信息/Info

Title:
Study on pregnancy outcome of complete asthenospermia treated with different sperm sources
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2020.02.005
作者:
王 磊; 高 明; 刘 项; 季兴哲; 孙建华; 周 梁△; 张 洲; 师娟子
西北妇女儿童医院生殖中心(西安 710003)
Author(s):
WANG Lei; GAO Ming; LIU Xiang; et al.
Reproductive Center of Northwest Women's and Children's Hospital(Xi'an 710003)
关键词:
弱精子症;  睾丸精子;  射出精子;  卵细胞浆内单精子显微注射技术;  男性不育症;  辅助生殖技术
Keywords:
Asthenospermia;  Testicular sperm;  Ejaculated sperm;  Intracytoplasmic sperm injection;  Male infertility;  Assisted reproductive technology
分类号:
R711.6
文献标志码:
A
摘要:
目的:探讨完全性弱精子症患者使用睾丸精子和射出精子行卵细胞浆内单精子显微注射技术(ICSI)治疗的妊娠结局。方法:回顾性分析因完全性弱精子症行ICSI治疗的患者的一般资料和妊娠结局。其中,使用睾丸精子组(A组)58周期,使用新鲜射出精子组(B组)80周期。结果:两组患者不孕年限、男女方年龄、受精率、卵裂率、正常受精率均无统计学差异,但射出精子组的优胚率(46.7%)高于睾丸精子组(42.6%),有统计学差异(P<0.05)。虽然射出精子组的临床妊娠率(65.4%)高于睾丸精子组(60.4%),射出精子组流产率(9.8%)低于睾丸精子组(12.5%),但均无统计学差异(P>0.05)。结论:完全性弱精子症患者行ICSI治疗时应先使用射出精子,避免睾丸穿刺取精。当新鲜射出精子无法使用时,为了避免冷冻卵子造成的影响,睾丸精子可作为备选方案。
Abstract:
Objective:To investigate the pregnancy outcomes of ICSI treatment with ejaculated sperm and testicular sperm in patients with absolute asthenospermia.Methods:The general data and pregnancy outcomes of intracytoplasmic sperm injection(ICSI)for absolute asthenospermia were retrospectively analyzed.58 cycles of testicular sperm group(group A)and 80 cycles of fresh ejaculated sperm group(group B)were used.Results:There was no significant difference in infertility years,age of men and women,fertilization rate,cleavage rate and normal fertilization rate between the two groups.However,the excellent embryo rate(46.7%)of ejaculated sperm group was higher than that of testicular sperm group(42.6%)with significant difference(P<0.05)。Although the clinical pregnancy rate of ejaculated sperm group(65.4%)was higher than that of testicular sperm group(60.4%),and the abortion rate of ejaculated sperm group(9.8%)was lower than that of testicular sperm group(12.5%),there was no significant difference(P>0.05).Conclusion:The patients with complete asthenospermia should use ejaculated sperm before ICSI treatment,so as to avoid testicular puncture and sperm extraction.If fresh ejaculated sperm can not be used,testicular sperm can be used as one of the options to avoid the impact of frozen eggs and obtain satisfactory pregnancy outcomes.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目(81771657)
更新日期/Last Update: 2020-03-25