[1]李丽丽,师萍萍△.血黄体生成素检测、经阴道超声卵泡监测联合不同促排卵方案 对多囊卵巢综合征患者妊娠结局的影响*[J].陕西医学杂志,2020,49(1):64-67.
　LI Lili,SHI Pingping..Effects of blood LH test,transvaginal ultrasound follicle monitoring combined with different ovulation induction regimens on pregnancy outcome in patients with polycystic ovary syndrome[J].,2020,49(1):64-67.
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血黄体生成素检测、经阴道超声卵泡监测联合不同促排卵方案 对多囊卵巢综合征患者妊娠结局的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年1期
页码:
64-67
栏目:
临床研究
出版日期:
2020-01-05

文章信息/Info

Title:
Effects of blood LH test,transvaginal ultrasound follicle monitoring combined with different ovulation induction regimens on pregnancy outcome in patients with polycystic ovary syndrome
文章编号:
DOI:10.3969/j.issn.10007377.2020.01.017
作者:
李丽丽; 师萍萍△
陕西省渭南市中心医院妇科（渭南 714000）
Author(s):
LI Lili; SHI Pingping.
Department of Gynecology,Weinan Central Hospital in Shaanxi Province(Weinan 714000)
关键词:
多囊卵巢综合征; 黄体生成素; 阴道B超; 促排卵; 药物性; 妊娠
Keywords:
Key words Polycystic ovary syndrome; Luteinizing hormone; Vaginal Bultrasound; Ovulation induction; Druginduced; Pregnancy
分类号:
R714.2
文献标志码:
A
摘要:
摘 要 目的：探讨血黄体生成素（LH）检测、阴道超声联合不同促排卵方案对多囊卵巢综合征（PCOS）患者妊娠结局的影响。方法：采用电脑软件随机形成数字表法对200例PCOS患者进行分组。A组通过注射Gn进行促排卵治疗，B组通过口服克罗米芬联合注射Gn进行促排卵治疗；C组通过口服来曲唑联合注射Gn进行促排卵治疗。三组均于月经周期第8～10 天时，阴道B超监测卵泡大小、数目等情况，当优势卵泡直径＞14 mm时，每天2次血LH测定，判断同房时机。对比三组HCG注射日E2子宫内膜厚度、成熟卵泡个数及单卵泡排卵情况；记录三组妊娠结局。结果：HCG注射日，三组患者激素E2子宫内膜厚度、成熟卵泡数目及单卵泡排卵占比间比较，差异均具有统计学意义（P＜005），B组和C组E2水平、子宫内膜厚度、成熟卵泡数目及单卵泡排卵占比均明显高于A组（P＜005），C组E2表达水平明显低于B组，子宫内膜厚度、成熟卵泡数目及单卵泡排卵占比明显高于B组（P＜005）。三组患者妊娠人数、自然流产率间差异均具有统计学意义（P＜005），与A组比，B组、C组妊娠人数占比明显增加，自然流产人数占比明显下降（P＜005），且C组妊娠人数占比明显高于B组（P＜005）；但三组生化妊娠率、双胎率间比较差异无统计学意义（P＞005）。结论：相较于单纯Gn和克罗米芬联合Gn促排卵，血LH检测、阴道超声监测下进行来曲唑联合Gn促排卵治疗，可更好地调节PCOS患者机体激素表达，改善其子宫内膜厚度，促进优势卵泡形成，提高女性妊娠率，预防自然流产。
Abstract:
Abstract Objective：To investigate the effects of blood luteinizing hormone(LH) detection,transvaginal ultrasound combined with different ovulation induction regimens on pregnancy outcome in patients with polycystic ovary syndrome(PCOS). Methods:200 patients with PCOS treated in our hospital were divided into three groups by randomly digital table method. Group A was treated with Gn for ovulation induction. Group B was treated with oral clomiphene plus Gn for ovulation induction. Group C was treated with oral letrozole combined with Gn for ovulation induction. In the three groups,the vaginal Bultrasound was used to monitor the size and number of follicles at the 8th to 10th day of the menstrual cycle,and when the dominant follicle diameter was ＞14 mm,the LH was measured twice a day to determine the timing of the same room. The hormone E2,endometrial thickness,number of mature follicles and single follicle ovulation were compared between the three groups of HCG injection days,and the pregnancy outcomes of the three groups were recorded. Results:On the day of HCG injection,the differences of hormone E2,endometrial thickness,number of mature follicles and single follicle ovulation in the three groups were significant(P＜005),and E2 levels,the endometrial thickness,the number of mature follicles and the proportion of single follicle ovulation in group B and C were significantly higher than those in group A(P＜005). The expression level of E2 in group C was significantly lower than that in group B. The endometrial thickness,the number of mature follicles and the proportion of single follicle ovulation were significantly higher than those of group B(P＜005). There were 〖LM〗significant differences in the number of pregnancy and spontaneous abortion between the three groups(P＜005). Compared with group A,the proportion of pregnancy in group B and group C increased significantly,and the proportion of spontaneous abortion decreased significantly(P＜005). The proportion of pregnancy in group C was significantly higher than that in group B(P＜005). However,there were no significant differences between the three groups in biochemical pregnancy rate and twin rate(P＞005). Conclusion:Compared with Gn and clomiphene combined with Gn to promote ovulation,blood LH detection,vaginal ultrasound monitoring of letrozole combined with Gn ovulation treatment,can better regulate the body hormone expression of PCOS patients,improve their endometrial thickness,promote the formation of dominant follicles,increase the pregnancy rate of women and prevent spontaneous abortion.

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备注/Memo

备注/Memo:
*陕西省医学科技研究项目(2013D24)
更新日期/Last Update: 2020-02-17