[1]李 赟.系统性红斑狼疮患者血清补体C5a和红细胞沉降率检测及临床意义[J].陕西医学杂志,2020,49(1):52-55.
　LI Yun..Expression of serum C5a and ESR in patients with systemic lupus erythematosus and its clinical significance[J].,2020,49(1):52-55.
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系统性红斑狼疮患者血清补体C5a和红细胞沉降率检测及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年1期
页码:
52-55
栏目:
临床研究
出版日期:
2020-01-05

文章信息/Info

Title:
Expression of serum C5a and ESR in patients with systemic lupus erythematosus and its clinical significance
文章编号:
DOI:10.3969/j.issn.10007377.2020.01.014
作者:
李 赟
西宁市第一人民医院风湿免疫血液科（西宁 810000）
Author(s):
LI Yun.
Department of Rheumatology and Immunology, The First People’s Hospital of Xining(Xining 810000)
关键词:
系统性红斑狼疮; 补体C5a; 红细胞沉降率; 系统性红斑狼疮活动评分表; 对比研究
Keywords:
Key words Systemic lupus erythematosus; Complement factor 5a; Erythrocyte sedimentation rate; Clinical significance; Systemic lupus erythematosus activity score; Comparative study
分类号:
R593.2
文献标志码:
A
摘要:
摘 要 目的： 探讨系统性红斑狼疮患者血清补体因子5a（C5a）、红细胞沉降率（ESR）的表达及临床意义。方法：收集119例系统性红斑狼疮患者为病例组，按照系统性红斑狼疮活动评分表（SLEDAI）分为无活动组（SLEDAI：0~4分，n=36）、轻度活动组（SLEDAI：5~9分，n=32）、中度活动组（SLEDAI：10~14分，n=27）、重度活动组（SLEDAI：≥15分，n=24）；并于同期随机选取60例健康体检者为对照组。采用酶联免疫吸附法检测血清C5a水平，魏氏法检测血清ESR水平。结果： 病例组血清补体C5a、ESR水平均高于对照组（P＜005）。轻度活动组、中度活动组、重度活动组血清补体C5a、ESR水平高于无活动组，且中度活动组、重度活动组高于轻度活动组，重度活动组高于中度活动组（P＜005）。经Pearson积矩相关分析，系统性红斑狼疮患者血清补体C5a、ESR与SLEDAI评分呈正相关关系（r=0.738、0.792，P＜005）。绘制ROC曲线评估血清补体C5a、ESR对活动期的诊断价值，补体C5a诊断活动期的AUC为0.836（95%CI：0.777~0.895），截断值为68.23 μg/ml，灵敏度、特异性分别为0.82、0.89，准确性为0.83；ESR诊断活动期的AUC为0.907（95%CI：0.863~0.951），截断值为47.65 mm/h，灵敏度、特异性分别为0.86、0.79，准确性为0.86；补体C5a联合ESR诊断活动期的AUC为0.939（95%CI：0.908~0.971），灵敏度、特异性分别为0.92、0.95，准确性为0.92。结论： 血清补体C5a、ESR参与了系统性红斑狼疮的发病过程，并且与病情严重性密切相关，早期联合检测可作为临床辅助诊断系统性红斑狼疮及评估病情的重要指标。
Abstract:
Abstract Objective：To explore the expression of serum complement factor 5a(C5a) and erythrocyte sedimentation rate(ESR) in patients with systemic lupus erythematosus and its clinical significance. Methods:A total of 119 patients with systemic lupus erythematosus admitted to our hospital from February 2016 to February 2019 were selected as case group,who were divided into no activity group(SLEDAI:0 to 4 scores,n=36),mild activity group(SLEDAI:5 to 9 scores,n=32),moderate activity group(SLEDAI:10 to 14 scores,n=27) and severe activity group(SLEDAI:≥15 scores,n=27) according to the SLE disease activity index(SLEDAI). At the same time,60 healthy volunteers were randomly selected as control group. Serum C5a level was detected by enzymelinked immunosorbent assay,and serum ESR level was measured by the Wilson’s method. Results:The serum C5a and ESR levels in case group were higher than those in control group(P＜005). The serum C5a,ESR levels in mild activity group,moderate activity group,severe activity group were higher than those in no activity group,which in moderate activity group and severe activity group were higher than those in mild activity group,and which in severe activity group were higher than those in moderate activity group(P＜005). Pearson product moment correlation analysis showed that serum C5a and ESR were positively associated with SLEDAI score(r=0.738,0.792,P＜005). The ROC curve was drawn to evaluate the diagnostic value of serum C5a and ESR in activity phase. The AUC of C5a in activity phase was 0.836(95%CI:0.777 to 0.895),the cutoff value was 68.23 μg/ml,and the sensitivity and specificity were 0.82 and 0.89,respectively,and the accuracy was 0.83. The AUC of ESR in activity phase was 0.907(95%CI:0.863 to 0.951),the cutoff value was 47.65 mm/h,and the sensitivity and specificity were 0.86 and 0.79,respectively,and the accuracy was 0.86. The AUC of C5a combined with ESR was 0.939(95%CI:0.908 to 0.971),and the sensitivity and specificity were 0.92 and 0.951,respectively,and the accuracy was 0.92. Conclusion:Serum C5a and ESR are involved in the pathogenesis of systemic lupus erythematosus,which are closely related to the severity of the disease. Early detection of both C5a and ESR can be used as important indicator for clinical diagnosis and evaluation of systemic lupus erythematosus.

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更新日期/Last Update: 2020-02-17