[1]马姣荣,刘成云△.促性腺激素释放激素激动剂对保留卵巢根治术患者卵巢功能的影响*[J].陕西医学杂志,2020,49(1):24-26.
　MA Jiaorong,LIU Chengyun..Effect of gonadotropinreleasing hormone agonist on ovarian function in patients undergoing ovarian radical resection[J].,2020,49(1):24-26.
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促性腺激素释放激素激动剂对保留卵巢根治术患者卵巢功能的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年1期
页码:
24-26
栏目:
临床研究
出版日期:
2020-01-05

文章信息/Info

Title:
Effect of gonadotropinreleasing hormone agonist on ovarian function in patients undergoing ovarian radical resection
文章编号:
DOI:10.3969/j.issn.10007377.2020.01.006
作者:
马姣荣; 刘成云△
陕西省榆林市中医医院（榆林 719000）
Author(s):
MA Jiaorong; LIU Chengyun.
Yulin Traditional Chinese Medicine Hospital in Shaanxi Province(Yulin 719000)
关键词:
GnRH激动剂; 保留卵巢根治术; 卵巢储备功能; 早期宫颈癌; 改良Kupperman评分
Keywords:
Key words GnRH agonist; Retention of ovarian radical surgery; Ovarian reserve function; Early cervical cancer; Improved kupperman score
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 目的：探讨促性腺激素释放激素（GnRH）激动剂对保留卵巢根治术患者卵巢功能的影响。方法：选取150例早期宫颈癌患者，按信封法分为对照组（n=75，保留卵巢根治术）及观察组（n=75，保留卵巢根治术联合GnRH激动剂），比较两组患者卵巢功能变化。结果：观察组化疗后基础卵泡刺激素（bFSH）、基础雌激素（bE2）水平低于对照组，血清抗菌勒管激素（AMH）、基础窦状卵泡数（bAFC）高于对照组，差异有统计学意义（P＜005）。观察组化疗后改良Kupperman评分（13.51±2.47）分低于对照组的（21.80±2.51）分，ENRICH评分（318.94±58.53）分高于对照组的（245.61±55.28）分，差异有统计学意义（P＜005）。结论：早期宫颈癌患者行保留卵巢根治术治疗，联合GnRH激动剂可保留患者卵巢储备功能。
Abstract:
Abstract Objective:To investigate the effect of gonadotropinreleasing hormone(GnRH) agonist on ovarian function in patients with ovarian radical resection. Methods:150 patients with early cervical cancer were enrolled. The patients were divided into the control group(n=75,ovarian radical resection) and the observation group(n=75,ovarian radical surgery combined with GnRH agonist). The ovarian function changes were compared between the two groups. Results:The levels of bFSH and bE2 in the observation group were lower than those in the control group. The AMH and bAFC were higher than that in the control group(P＜005). The improved Kupperman score(13.51±2.47) in the observation group was lower than that in the control group(21.80±2.51),and the ENRICH score(318.94±58.53) was higher than that in the control group(245.61±55.28),which were statistically significant(P＜005). Conclusion:In treatment of patients with early cervical cancer,ovarian radical resection combined with GnRH agonist can preserve the ovarian reserve function of patients. Its clinical value is high to be worthy of promotion.

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备注/Memo

备注/Memo:
*陕西省教育厅科学研究项目(2013JK0782)
更新日期/Last Update: 2020-02-17