[1]沈斯瑶,刘 艳△,徐鹏刚.白芍总苷联合沙利度胺治疗强直性脊柱炎疗效及对患者活动指标、血清炎性因子水平的影响*[J].陕西医学杂志,2020,49(1):20-23.
　SHEN Siyao,LIU Yan,XU Penggang..Effect of total glucosides of paeony combined with thalidomide on activity indicators and serum inflammatory factors in the treatment of ankylosing spondylitis patients[J].,2020,49(1):20-23.
点击复制

白芍总苷联合沙利度胺治疗强直性脊柱炎疗效及对患者活动指标、血清炎性因子水平的影响*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年1期
页码:
20-23
栏目:
临床研究
出版日期:
2020-01-05

文章信息/Info

Title:
Effect of total glucosides of paeony combined with thalidomide on activity indicators and serum inflammatory factors in the treatment of ankylosing spondylitis patients
文章编号:
DOI:10.3969/j.issn.10007377.2020.01.005
作者:
沈斯瑶1; 刘 艳2△; 徐鹏刚1
1.西安市第五医院（西安 710082）；2.西安交通大学第一附属医院（西安710061）
Author(s):
SHEN Siyao; LIU Yan; XU Penggang.
Xi’an No.5 Hospital（Xi’an 710082）
关键词:
白芍总苷; 沙利度胺; 强直性脊柱炎; 活动指标; 血清炎性因子水平; 不良事件
Keywords:
Key words Total glucosides of paeony; Thalidomide; Ankylosing spondylitis; Activity indicators; Serum inflammatory factor levels; Adverse events
分类号:
R681
文献标志码:
A
摘要:
摘 要 目的：探讨白芍总苷联合沙利度胺治疗强直性脊柱炎对患者活动指标及血清炎性因子水平的影响。方法：选取强直性脊柱炎患者60例，按治疗方式分为两组，各30例，对照组仅予以沙利度胺进行治疗，研究组予以沙利度胺联合白芍总苷进行治疗，比较两组治疗效果、活动指标、炎性因子水平变化情况以及出现不良事件的概率。结果：对照组治疗有效率低于研究组（P＜005），治疗后对照组各指标水平低于研究组（P＜005），治疗后对照组白介素17（IL17）、C反应蛋白（CRP）、白介素1β（IL1β）水平都高于研究组（P＜005），对照组出现不良事件的概率高于研究组（P＜005）。结论：在治疗强直性脊柱炎患者的过程中，白芍总苷联合沙利度胺治疗效果显著。
Abstract:
Abstract Objective：To investigate the effect of total glucosides of paeony combined with thalidomide on activity indicators and serum inflammatory factors in the treatment of ankylosing spondylitis patients. Method：60 cases of ankylosing spondylitis patients were randomly divided into research group and control group,each 30 cases. The control group was treated with thalidomide. The research group was treated with total glucosides of paeony and thalidomide. Treatment effect,activity indicators,inflammatory factor levels and the probability of adverse events were compared. Results：The effective rate of treatment in the control group was lower than that in the research group(P＜005). After treatment,all indexes in the control group were worse than those in the research group(P＜005),the levels of IL17,CRP and IL1 beta in the control group were higher than those in the research group(P＜005),and the probability of adverse events in the control group was higher than that in the research group(P＜005). Conclusion：In the treatment of ankylosing spondylitis patients,treatment effect of total glucosides of paeony combined with thalidomide is significant,which is worthy of more extensive clinical application.

参考文献/References:

[1] 刘志燕,柳 芳,李朋梅,等.白芍总苷胶囊联合柳氮磺吡啶片比较柳氮磺吡啶片治疗强直性脊柱炎的疗效和安全性的Meta分析[J].中国药房,2018,29(17):118122.
[2] 郭乃亮.补肾强督治尪汤加减治疗肾虚督寒型强直性脊柱炎疗效及对患者炎症因子的影响[J].陕西中医,2019,40(10):13941396，1414.
[3] Zhao YH，Cao YY，Zhang Q，et al.Role of diffusionweighted and contrastenhanced magnetic resonance imaging in differentiating activity of ankylosing spondylitis[J].Chinese Medical Journal，2017，130(11):13031308.
[4] 杨以琳,潘竞锵,谭淑珍,等.白芍总苷对非酒精性脂肪性肝病大鼠肝组织网膜素、TLR4表达的影响[J].中药药理与临床,2017，19(3):6265.
[5] 杨海青,邱发麒.沙利度胺对老年急性髓系白血病患者血清碱性成纤维细胞生长因子、血管内皮生长因子水平的影响[J].中国老年学杂志,2018,38(24):59365938.
[6] 邹宇聪,毛 筝,徐敏鹏,等.雷公藤多苷含药血清对强直性脊柱炎病理性骨化相关炎症因子和miR21的影响[J].实用医学杂志,2017,33(3):367370.
[7] 左 政,刘自力,袁 恺,等.基于Th17/Treg/Th1免疫失衡探讨长蛇灸干预强直性脊柱炎的疗效及机制研究[J].中国针灸,2018,38(10):3135.
[8] 刘 勇,孙俊英,王 涛,等.全髋关节置换术治疗强直性脊柱炎累及髋关节的疗效观察[J].中国修复重建外科杂志,2017，50(1):2530.
[9] 孙 鹏,李 建,沙明波,等.独活寄生汤加减对强直性脊柱炎肾虚督寒证骨代谢和炎症因子的影响[J].中国实验方剂学杂志,2017，58(24):202207.
[10] 戴 璐.柳氮磺胺吡啶联合益赛普治疗不同年龄强直性脊柱炎临床效果及对患者生活质量的影响研究[J].陕西医学杂志,2019,48(2):262265.
[11] Sakellariou GT，Iliopoulos A，Konsta M，et al.Serum levels of Dkk1，sclerostin and VEGF in patients with ankylosing spondylitis and their association with smoking，and clinical，inflammatory and radiographic parameters[J].Joint Bone Spine，2017，84(3):309315.
[12] 田 浩,王 辉,狄鹤轩,等.跳跃式双节段经椎弓根截骨长节段融合治疗强直性脊柱炎胸腰椎后凸畸形[J].中国脊柱脊髓杂志,2018,28(3):193199.
[13] 吉健华,成 洁.雷公藤多苷治疗强直性脊柱炎的疗效及对患者可溶性白介素2受体的影响[J].海南医学,2019,30(22):29052908.
[14] Molnar C，Scherer A，Baraliakos X，et al.TNF blockers inhibit spinal radiographic progression in ankylosing spondylitis by reducing disease activity：results from the Swiss Clinical Quality Management cohort[J].Annals of the Rheumatic Diseases，2018，77(1):6369.
[15] 吴容军,张进城.中药熏蒸联合针灸治疗老年肾虚寒湿型强直性脊柱炎的临床疗效及其对炎性因子的影响[J].临床合理用药杂志,2019,12(27):108109，111.
[16] 陈国材,许学猛,陈 能,等.强直性脊柱炎与骨质疏松症中医治疗方剂用药规律比较分析[J].中国中医基础医学杂志,2017，52(2):254256.
[17] 罗绮雯,陈国强,张红卫,等.依那西普注射剂联合雷公藤多苷片治疗强直性脊柱炎的临床研究[J].中国临床药理学杂志,2019,35(15):15781580.
[18] Sellasi F，Agusti JR，Xavier AR，et al.Clinical utility of the ASDAS index in comparison with BASDAI in patients with ankylosing spondylitis(Axis Study)[J].Rheumatology International，2017，37(11):18171823.
[19] 贺冬冬,张素养,刘昌莲,等.沙利度胺片联合依托考昔片治疗中轴型强直性脊柱炎的效果及作用机制[J].临床医学研究与实践,2019,4(23):1416.
[20] 高全彩,吴红葵,林小娟.白芍总苷对稳定期慢性心力衰竭的疗效及对炎症水平的影响[J].临床心血管病杂志,2018,34(9):8790.
[21] Song R，Chung SW，Lee SH.Radiographic evidence of hip joint recovery in patients with ankylosing spondylitis after treatment with antitumor necrosis factor agents：a case series[J].Journal of Rheumatology，2017，44(11):17591760.

相似文献/References:

[1]贺地震,刘谦性△.沙利度胺联合甲氨蝶呤治疗类风湿性关节炎疗效及对患者调节性T细胞、白细胞介素6水平影响临床研究[J].陕西医学杂志,2019,(1):111.
[2]郝运宏,李新新,翟鑫鼎,等.二联药物方案辅助窄谱中波紫外线治疗寻常型银屑病疗效研究*[J].陕西医学杂志,2019,(9):1212.
　HAO Yunhong,LI Xinxin,ZHAI Xinding,et al.The efficacy of the dualdrug regimen in assisting narrowband〖JZ〗 UVB (NBUVB) for psoriasis vulgaris[J].,2019,(1):1212.

备注/Memo

备注/Memo:
*陕西省中医管理局中医药科研课题（15SCJH037）
更新日期/Last Update: 2020-02-17