[1]亢相逢,曹 玲△,崔 巍,等.哮喘患儿外周血MMP9、IFNγ及MIP1α水平变化及其与肺功能相关性研究[J].陕西医学杂志,2019,(11):1464-1467.
　KANG Xiangfeng,CAO Ling,CUI Wei,et al.Changes of MMP9，INFγ and MIP1α in peripheral blood of asthmatic children and the correlation with lung function[J].,2019,(11):1464-1467.
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哮喘患儿外周血MMP9、IFNγ及MIP1α水平变化及其与肺功能相关性研究

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年11期
页码:
1464-1467
栏目:
临床研究
出版日期:
2019-11-05

文章信息/Info

Title:
Changes of MMP9，INFγ and MIP1α in peripheral blood of asthmatic children and the correlation with lung function
文章编号:
DOI:10.3969/j.issn.10007377.2019.11.015
作者:
亢相逢; 曹 玲△; 崔 巍; 王英娟
陕西省榆林市第一医院儿科(榆林719000)
Author(s):
KANG Xiangfeng; CAO Ling; CUI Wei; et al
Department of Pediatrics，The First Hospital of Yulin in Shaanxi Province(Yulin 719000)
关键词:
哮喘; 基质金属蛋白酶9; 干扰素γ; 巨噬细胞炎症蛋白1α; 肺功能; 相关性
Keywords:
Key words Asthma; Matrix metalloproteinase9; Interferonγ; Macrophage inflammatory protein1α; Lung function; Relevance
分类号:
R7256
文献标志码:
A
摘要:
摘 要 目的：探讨哮喘患儿外周血基质金属蛋白酶9（MMP9）、干扰素γ（IFNγ）、巨噬细胞炎症蛋白1α（MIP1α）水平变化及其与肺功能的相关性。方法：选取86例支气管哮喘患儿为哮喘组，100例健康儿童为健康组。检测两组患者血清MMP9、IFNγ、MIP1α水平和呼气峰流速（PEF）及第1秒用力呼气容积占肺活量的百分比（FEV1/FVC）等肺功能指标，探讨血清MMP9、IFNγ、MIP1α与支气管哮喘患儿肺功能状况的相关性。结果：哮喘组患儿血清MMP9、MIP1α表达水平均高于健康组，而哮喘组血清IFNγ水平及肺功能PEF、FEV1/FVC则低于健康组（P＜005）。哮喘患儿血清MMP9表达水平与肺功能指标PEF、FEV1/FVC均呈显著负相关（r=-0399，P＜005；r=-0407,P＜005），MIP1α水平与PEF、FEV1/FVC也呈显著负相关（r=-0380，P＜005；r=-0346,P＜005）；而血清IFNγ水平与PEF、FEV1/FVC呈显著正相关（r=0460，P＜005；r=0431,P＜005）。治疗后，治疗有效组患儿血清MMP9、MIP1α水平均明显低于治疗无效组，血清INFγ水平则高于无效组（P＜005）。结论：哮喘患儿血清MMP9、IFNγ、MIP1α水平与肺功能状况密切相关，对其检测有助于对支气管哮喘患儿肺功能判断和治疗效果评估。
Abstract:
Abstract Objective:To investigate the changes of matrix metalloproteinase9 (MMP9)，interferonγ (INFγ)，macrophage inflammatory protein1α (MIP1α) in peripheral blood of asthmatic children and the correlation with lung function Methods:86 children with bronchial asthma were selected as asthma group and 100 healthy children as healthy group Serum MMP9,INFγ，MIP1α levels，PEF and FEV1/FVC were measured The correlation of serum MMP9,INFγ,MIP1α in bronchial asthma with pulmonary function in children were investigated Results:The expression levels of MMP9，MIP1α in asthmatic group were higher than those in healthy group，while the serum INFγ and PEF，FEV1/FVC in asthma group were lower than those in healthy group (P＜005) The expression level of serum MMP9 in asthmatic children was significantly negatively correlated with PEF and FEV1/FVC (r=-0399,P＜005；r=-0407,P＜005)，the level of MIP1α was significantly negatively correlated with PEF and FEV1/FVC (r=-0380，P＜005；r=-0346,P＜005)，while the level of serum INFγ was positive correlated with PEF and FEV1/FVC (r=0460，P＜005；r=0431,P＜005) After treatment，the serum levels of MMP9，MIP1α in effective group were significantly lower than those in ineffective group，while the level of INFγ was significantly higher than ineffective group (P＜005) Conclusion:Serum MMP9，INFγ，MIP1α levels are closely related to pulmonary function in asthmatic children It is helpful to diagnose and evaluate the treatment effect of bronchial asthma 

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更新日期/Last Update: 2019-11-15