[1]朱志坚,孙丽芳,陆志刚 .外周血中性粒细胞/淋巴细胞比值对急性心肌梗死患者预后的预测价值[J].陕西医学杂志,2019,(10):1326-1329.
　ZHU Zhijian,SUN Lifang,LU Zhigang..Prognostic value of peripheral blood neutrophil/lymphocyte ratio for 〖JZ〗longterm prognosis in patients with acute myocardial infarction[J].,2019,(10):1326-1329.
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外周血中性粒细胞/淋巴细胞比值对急性心肌梗死患者预后的预测价值
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年10期
页码:
1326-1329
栏目:
临床研究
出版日期:
2019-10-05

文章信息/Info

Title:
Prognostic value of peripheral blood neutrophil/lymphocyte ratio for 〖JZ〗longterm prognosis in patients with acute myocardial infarction
文章编号:
DOI:10.3969/j.issn.10007377.2019.10.022
作者:
朱志坚1; 孙丽芳1; 陆志刚2 
1.上海市第六人民医院金山分院心内科(上海201599)；2.上海市第六人民医院心内科(上海200233)
Author(s):
ZHU Zhijian; SUN Lifang; LU Zhigang.
Department of Cardiology,Jinshan Branch of Shanghai Sixth People’s Hospital(Shanghai 201599)
关键词:
急性心肌梗死; 中性粒细胞/淋巴细胞比值; 病死率; 预后; 预测价值
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗Acute myocardial infarction; Neutrophil/lymphocyte ratio; Mortality; Prognosis; Predictive value
分类号:
R541.4
文献标志码:
A
摘要:
摘 要 目的：探讨外周血中性粒细胞/淋巴细胞(N/L)比值对急性心肌梗死（AMI）患者预后的预测价值。方法：纳入经皮冠状动脉介入治疗（PCI）治疗的184例AMI患者，检测患者的N/L比值，采用多因素Cox回归分析探讨AMI患者住院期间病死率和长期随访期间死亡率与外周血N/L比值的相关性。结果：184例AMI患者的平均N/L比值为4.82。第4分位数患者的平均年龄（63.9±4.8岁）、外周血WBC数量（10.9±3.0）明显高于第1至第3四分位数的患者；第4分位数患者的Killip心功能Ⅳ级比例（4.35%）和左心室射血分数＜45%比例（14.39%）明显高于第1至第3四分位数的患者；第4分位数患者在院内（13.04%）及术后6个月病死率（26.09%）明显高于第1至第3四分位数的患者；两者以上差异均具有统计学意义（P＜0.05）。N/L比值多因素Cox回归分析结果显示，外周血N/L比值是AMI患者死亡的独立预测因子（HR 2.38,95％ CI 1.423.98;P=0.001）。结论：外周血N/L比值是AMI患者接受PCI治疗后长期病死率的独立预测因子。
Abstract:
Abstract 〖WT5BZ〗〖HT5”SS〗Objectives:This study was designed to investigate the predictive value of peripheral blood neutrophil/lymphocyte (N/L) ratio in patients with acute myocardial infarction (AMI) for longterm prognosis.Methods：This study included 184 patients with AMI who underwent percutaneous coronary intervention (PCI) .The N/L ratio was measured in patients.Multivariate Cox regression analysis was used to investigate the inhospital mortality and longterm followup mortality and peripheral blood N/L ratio.Results:The average N/L ratio of 184 patients with AMI was 4.82.The average age of patients in quartile 4 (63.9±4.8 years old) and the number of WBC in peripheral blood (10.9±3.0) were significantly higher than those in quartile 1 to 34;the proportion of Killip grade IV (4.35%) and left ventricular ejection fraction＜45% (14.39%) in quartile 4 were significantly higher than those in quartile 1 to 34;patients in quartile 4 died in hospital (13.04%) and 6 months after operation.The mortality rate (26.09%) was significantly higher than that of the patients in quartile 1 to 34 (P＜0.05).Multivariate Cox regression analysis showed that the N/L ratio of peripheral blood was an independent predictor of mortality in patients with AMI (HR 2.38,95% CI 1.423.98;P=0.001).Conclusion:N/L ratio in peripheral blood is an independent predictor of longterm mortality after PCI in AMI patients.

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更新日期/Last Update: 2019-10-23