[1]郝运宏,李新新,翟鑫鼎,等.二联药物方案辅助窄谱中波紫外线治疗寻常型银屑病疗效研究*[J].陕西医学杂志,2019,(9):1212-1215.
　HAO Yunhong,LI Xinxin,ZHAI Xinding,et al.The efficacy of the dualdrug regimen in assisting narrowband〖JZ〗 UVB (NBUVB) for psoriasis vulgaris[J].,2019,(9):1212-1215.
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二联药物方案辅助窄谱中波紫外线治疗寻常型银屑病疗效研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1212-1215
栏目:
药物与临床
出版日期:
2019-09-05

文章信息/Info

Title:
The efficacy of the dualdrug regimen in assisting narrowband〖JZ〗 UVB (NBUVB) for psoriasis vulgaris
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2019.09.029
作者:
郝运宏; 李新新; 翟鑫鼎; 徐艳红
首都医科大学密云教学医院（北京 101500）
Author(s):
HAO Yunhong ; LI Xinxin ; ZHAI Xinding; et al.
Miyun Teaching Hospital,Capital Medical University(Beijing 101500)
关键词:
窄谱中波紫外线; 阿维A; 白芍总苷; 寻常型银屑病; 皮损
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗〖JP2〗Narrowband UVB; Avi A; Total glucosides of paeony; Psoriasis vulgaris; Dermatological damage
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 〖HT5K〗目的：探讨二联药物方案辅助窄谱中波紫外线(NBUVB)对寻常型银屑病的疗效。方法：收集将其寻常型银屑病患者随机分为两组。NBUVB组患者给予窄谱中波紫外线治疗，联合组患者则加用二联药物，比较两组患者PASI评分、总体治疗效果、相关血清指标、照射相关指标、不良反应与复发率。结果：两组患者治疗后皮损面积、红斑、浸润肥厚、瘙痒程度、鳞屑与PASI总分组间比较均显著低于同组治疗前；联合组患者治疗后皮损面积、红斑、浸润肥厚、瘙痒程度、鳞屑与PASI总分组间比较均显著低于NBUVB组，总有效率明显高于NBUVB组；两组患者治疗后TNFα、PRL、IL8、IL2、IFNγ、IL17、IL22、IL23与IL4水平组间比较均显著低于同组治疗前；治疗后TNFα、PRL、IL8、IL2、IFNγ、IL17、IL22、IL23与IL4水平组间比较均显著低于NBUVB组；累积剂量、治疗时间、不良反应与复发率均显著低于NBUVB组，差异具有统计学意义（P＜0.05）。结论：二联药物方案辅助NBUVB对寻常型银屑病的疗效显著，可有效提升NBUVB治疗效果，辅助效果明显。
Abstract:
Abstract 〖WT5BZ〗〖HT5”SS〗Objective：To investigate the efficacy of the dualdrug regimen in assisting narrowband UVB (NBUVB) for psoriasis vulgaris. Methods:The patients with psoriasis vulgaris were randomly divided into two groups. Patients in the NBUVB group received narrowband UVB treatment，and patients in the combination group received dualdrug therapy. The PASI score，overall treatment effect，related serum index，exposurerelated indicators，adverse reactions and recurrence rate were compared between the two groups. Results：The area of skin lesions，erythema，infiltration hypertrophy，pruritus，scaly and PASI total group were significantly lower than those in NBUVB group. The total effective rate was significantly higher than that of NBUVB group. TNFα，PRL，IL8，IL2，IFNγ，IL17，IL22，IL23 and IL4 levels were significantly lower than the NBUVB group；cumulative dose，treatment The time，adverse reactions and recurrence rate were significantly lower than those in the NBUVB group，and the difference was statistically significant (P＜0.05). Conclusion：The combination of NBUVB and NBUVB has a significant effect on psoriasis vulgaris. 

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备注/Memo

备注/Memo:
*首都卫生发展科研专项（201637151）
更新日期/Last Update: 2019-09-24