[1]王 荣,贾爱华,刘新艳 ,等.IGF1及其相关性因素对2型糖尿病并发骨质疏松的影响研究[J].陕西医学杂志,2019,(9):1163-1166.
　WANG Rong,JIA Aihua,LIU Xinyan,et al.The effect of IGF1 and its related factors in type 2 diabetes complicated with osteoporosis[J].,2019,(9):1163-1166.
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IGF1及其相关性因素对2型糖尿病并发骨质疏松的影响研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1163-1166
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
The effect of IGF1 and its related factors in type 2 diabetes complicated with osteoporosis
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2019.09.015
作者:
王 荣1; 贾爱华1; 刘新艳1 ; 井长信1; 马江卫2△
1.陕西省榆林市第一医院内分泌科（榆林 719000)； 2 陕西省榆林市第一医院骨一科（榆林719000）
Author(s):
WANG Rong; JIA Aihua; LIU Xinyan; et al.
Department of Endocrinology, the First Hospital of Yulin City(Yulin 719000)
关键词:
2型糖尿病; 骨质疏松; 胰岛素样生长因子1; 25羟维生素D; 危险因素
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗Type 2 diabetes; Osteoporosis; Insulinlike growth factor 1; 25 hydroxy vitamin D; Risk factors
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 〖HT5K〗目的：观察2型糖尿病（T2DM）并发骨质疏松（OP）患者血清胰岛素样生长因子1（IGF1）水平变化，分析其相关影响因素，探讨IGF1在T2DM并发OP中的作用。方法：T2DM患者80例，依据骨密度测定结果分为观察组40例（T2DM并发OP）及对照组40例（T2DM未并发OP）。采用酶联免疫吸附法检测血清IGF1、P1NP、βCTX，化学发光法检测血清25(OH)D，同时测定FBG、FINS，计算HOMAIR。Persom相关性分析观察组IGF1及其相关影响因素。Losgistic回归模型判定T2DM并发OP的危险因素。结果：观察组血清IGF1、25(OH)D水平显著低于对照组，而FBG、FINS、HOMAIR、HbA1c及βCTX显著高于对照组。观察组IGF1水平与FBG、FINS、HOMAIR及βCTX显著负相关，与骨密度及25(OH)D显著正相关。Logistic回归分析提示IGF1、FBG、FINS、HOMAIR、HbA1c、βCTX及25(OH)D是T2DM并发OP的影响因素。结论：低水平的IGF1及25(OH)D与FBG、FINS、HOMAIR、HbA1c及βCTX的升高是T2DM并发OP的危险因素，针对危险因素进行早期干预治疗，可降低T2DM并发OP的风险。 
Abstract:
Abstract 〖WT5BZ〗Objective：To observe the change of serum IGF1 level, analyze the relevant influencing factors, and explore the role of IGF1 in T2DM complicated with OP. Method：80 patients with T2DM admitted were selected and divided into the observation group (40 cases of T2DM complicated with OP) and the control group (40 cases of T2DM without OP) according to the results of BMD measurement. The serum IGF1, P1NP and βCTX were detected by enzymelinked immunosorbent assay, the serum 25(OH)D was determined by chemiluminescence assay. The FBG, FINS and HbA1c were determined, then HOMAIR was calculated. The IGF1 and its related influencing factors in the observation group were analyzed by Pearson correlation. Finally, the risk factors of T2DM complicated with OP were evaluated by logistic regression analysis. Results：The serum IGF1 and 25(OH)D levels in the observation group were significantly lower, while the FBG, FLNS, HOMAIR， HbA1c and βCTX levels were significantly higher than those in the control group. The serum IGF1 level in the observation group was significantly negatively correlated with FBG, FINS, HOMAIR, and βCTX, and positively correlated with BMD and 25(OH)D. Logistic regression analysis indicates that IGF1, FBG, FINS, HOMAIR, HbA1c, βCTX and 25(OH)D are involved in the occurrence of T2DM complicated with OP. Conclusion：Low levels of IGF1 and 25(OH)D, high levels of FBG, FINS, HOMAIR, HbA1c and βCTX are risk factors for T2DM complicated with OP. Early intervention for risk factors can reduce the risk of T2DM complicated with OP.

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更新日期/Last Update: 2019-09-24