[1]刘海娟,温有锋△.尿毒症266例体成分特点研究*[J].陕西医学杂志,2019,(9):1130-1133.
　LIU Haijuan,WEN Youfeng..Characteristics of body composition in patients with uremia[J].,2019,(9):1130-1133.
点击复制

尿毒症266例体成分特点研究*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1130-1133
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
Characteristics of body composition in patients with uremia
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2019.09.007
作者:
刘海娟1; 2 ; 温有锋1△
1.锦州医科大学生物人类学研究所 (锦州 121001)；2.辽宁省大连市瓦房店市中心医院肾内科（瓦房店 116300)
Author(s):
LIU Haijuan; WEN Youfeng.
Jin zhou Medical University（Jinzhou 121001)
关键词:
尿毒症; 体成分; 肌肉含量; 脂肪含量
Keywords:
Key words 〖WT5BZ〗〖HT5”SS〗Uremia; Body composition; Muscle content; Fat content
分类号:
R692.5
文献标志码:
A
摘要:
摘 要 〖HT5K〗目的：探讨尿毒症对体成分的影响。方法：随机抽取行血液透析治疗的尿毒症患者266例，及同期体检的健康成人139例。将每个性别分为健康组(CG)、尿毒症≥3年组（UG1）和尿毒症＜3年组（UG2）。按照《人体测量方法》测量其身高、体质量，利用生物电阻抗分析仪对其进行肌肉含量、脂肪含量等多项体成分的测定。结果：男性组肌肉量的测量结果表明CG组和UG2组的全身肌肉量均显著高于UG1组(P＜0.05)，CG组的下肢肌肉量显著高于UG1组(P＜0.05)，其余各组间比较均无统计学差异。女性组肌肉量的测量结果表明，除CG组的左上肢肌肉量和右下肢肌肉量显著高于UG1组外（P＜0.05），其余各组间比较均无统计学差异。三组间男女性的脂肪含量比较差异无统计学意义（P＞0.05）。结论：随着尿毒症患者病程的延长，患者的肌肉含量会随之减少，男性较女性明显，而对脂肪含量影响不明显。
Abstract:
Abstract 〖WT5BZ〗〖HT5”SS〗Objective：To investigate the effect of uremia on body composition. Methods:With informed consent，266 uremic patients (male：158，female：108) were randomly selected. Uremic patients aged 40~60 and 139 healthy adults(male：71，female：68)who were examined in hospital at the same time were divided into (CG)，uremia≥3 years group (UG1) and uremia ＜ 3 years group (UG2). The body weight and height were measured according to the method of anthropometry. The muscle content，fat content and so on were measured by bioelectrical impedance analyzer.Results：The results of measurement of muscle volume in male group showed that the muscle volume of lower extremity in CG group and UG2 group was significantly higher than that in UG1 group (P＜0.05)，but there was no significant difference between the other groups (P＜0.05). The results showed that the muscle volume of left upper limb and right lower limb in CG group was significantly higher than that in UG1 group (P＜0.05)，but there was no significant difference in other groups. There was no significant difference in fat content between the three groups (P＞0.05). Conclusion:with the prolongation of the course of uremia，the muscle content of uremia patients is increased. With this decrease，men are more pronounced than women，but have no significant effect on fat content.

参考文献/References:

[1] 〖ZK（#〗李作君. 慢性肾脏病的流行现状与防治[J] . 临床合理用药杂志，2013，6(26):119119.
[2] 周浩明，杨军平. 慢性肾衰竭微血管的中西医保护机制研究进展[J] . 实用中西医结合临床，2016，16(11):9294.
[3] 白小洁. 血液透析病人的营养护理[J] . 中国中西医结合肾病杂志，2002(10):610611.
[4] Baliga R，George VT,Ray PE,et al. Effects of reduced renal function and dietary protein on muscle protein synthesis [J] . Kidney Int，1991，39(5):831835.
[5] Kim JK,Choi SR,Choi MJ,et al.Prevalence of and factors associated with sarcopenia in elderly pationts with endstage renal disease[J] .Clin Nutr,2014,33(1):6468.
[6] Hakim R M. Predictive measures of vascular access thrombosis：a prospective study.[J] . Kidney International，1997，52(6):16561662.
[7] 陈 昭,席焕久.人体测量方法[M].2版.北京:科学出版社,2010:4748. 
[8] A Sayer A,Stewart C,Patel H,et al.The developmental origins of sarcopenia:from epidemiological evidence to underlying mechanisms[J] .J Dev Orig Health Dis，2010，1(3):150157. 
[9] Domański M，Ciechanowski K. Sarcopenia：A major challenge in elderly patients with endstage renal disease[J] . Journal of Aging Research,2012，2012(10):754739. 〖ZK)〗
[10] 〖ZK(#〗Greco A，Paroni G，Seripa D,et al. Frailty，disability and physical exercise in the aging process and in chronic kidney disease [J] .Kidney Blood Press Res，2014，39(23):164168.
[11] Kim JC，KalantarZadeh K，Kopple JD. Frailty and proteinenergy wasting in elderly patients with end stage kidney disease\[J \]. J Am Soc Nephrol，2013，24(3):337351. 
[12] 任红旗,龚德华.尿毒症肌少症的发病机制和治疗[J] .肾脏病与透析肾移植杂志,2015,24(2):181185.
[13] 黄丽娅，李少华，翁 敏，等. 维持性血液透析病人骨骼肌减少症发生率和危险因素研究[J] . 肠外与肠内营养，2017，24(2):7881.
[14] Mak RH,Ikizler AT,Kovesdy CP,et al.Wasting in chronic kidney disease[J] . Cachexia Sarcopenia Muscle,2011,2(1):925.
[15] 孙春晓，郭兆安. 慢性肾脏病血脂代谢紊乱的影响因素及其机制的研究进展[J] . 中国中西医结合肾病杂志，2014，(6):546548.
[16] 陶建瓴,李学旺. 慢性肾脏病脂质异常的治疗及意义[J] . 中国实用内科杂志,2010,30(10):872874.
[17] 余永武，杨峥维，张雅芳，等. 医院船就诊拉美3国人群中慢性肾脏疾病与脂质代谢的关系研究[J] . 西北国防医学杂志，2012，33(3):245247.
[18] Executive Summary of the third report of the nationalc holesteroleducation program ( NCEP ) . Expert panel on detection，evaluation，and treatment of high blood cholesterol in adults (AdultTreatm ent Panel III) [J] . JAMA，2001，285（1）：2486 2497.
[19] Lipoproteins in maintaining cholesterol efflux from Fu5AH cells to plasma from insulinresistant subjects[J] .Scand J C lin Lab Invest,2001,61(1):6974.
[20] 宋春奇,刘 畅.生物时钟与脂肪组织代谢整合机制研究进展[J] .生命科学,2015,27(11):14181426.

相似文献/References:

[1]陈 昕,张 莹.血液透析联合血液灌流对尿毒症患者毒素清除率、炎性因子、钙磷代谢及免疫功能的影响*[J].陕西医学杂志,2019,(6):770.
　CHEN Xin,ZHANG Ying.Effect of hemodialysis combined with hemoperfusion on toxin clearance rate,inflammatory factors, Calcium-phosphorus metabolism and immune function in patients with uremia[J].,2019,(9):770.
[2]罗孔认,陈梦诗,陈珊娜.甲壳质酶蛋白40、中性粒细胞载脂蛋白及基质金属蛋白酶-9水平与尿毒症维持性血液透析患者感染相关性研究[J].陕西医学杂志,2023,52(10):1362.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.017]
　LUO Kongren,CHEN Mengshi,CHEN Shanna.Correlation of YKL-40,NGAL and MMP-9 levels with infection in uremic patients undergoing maintenance hemodialysis[J].,2023,52(9):1362.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.017]

备注/Memo

备注/Memo:
*国家自然科学基金资助项目（31571233）
更新日期/Last Update: 2019-09-24