[1]舒 放,王海峰,薛飞肖,等.不同性别MTHFR基因多态性协同叶酸水平差异〖JZ〗对血清同型半胱氨酸的影响研究[J].陕西医学杂志,2019,(9):1119-1121，1125.
点击复制

不同性别MTHFR基因多态性协同叶酸水平差异〖JZ〗对血清同型半胱氨酸的影响研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1119-1121，1125
栏目:
基础研究
出版日期:
2019-09-05

文章信息/Info

文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007377.2019.09.004
作者:
舒 放1; 王海峰1; 薛飞肖1; 宁 可1; 史珊珊1; 吕海港2△
1.西安市第三医院检验科(西安 710018)；2.西安市红会医院麻醉科(西安 710054）
关键词:
同型半胱氨酸; 亚甲基四氢叶酸还原酶; 叶酸; 基因多态性
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 〖HT5K〗目的：探讨不同性别MTHFR基因多态性协同叶酸（Fol）水平对血清同型半胱氨酸（Hcy）的影响。方法：收集18~75岁受检者88例，检测其血清Fol、Hcy等指标，并进行MTHFR基因多态性检测。分析不同性别的血压（BP）、血糖（Glu）、甘油三酯（TG）、总胆固醇（TC）等各基本健康参数水平的差异性。不同性别MTHFR基因多态性分布特点及差异性。不同性别MTHFR基因多态性血清Hcy水平的差异性及与Fol水平的关系。结果：不同性别的年龄、Glu、TG、TC各参数比较无统计学差异，而BP比较有统计学差异（P＜0.05）；88例中MTHFR C677C型占14.8%，C677T型占47.7%；T677T型占37.5%，不同性别间比较差异无统计学意义。三种MTHFR基因多态性样本组间血清Hcy水平比较有统计学差异，其中MTHFR T677T型合并叶酸缺乏者血清Hcy水平与本组叶酸不缺乏者比较，有统计学差异（P＜0.05）；不同性别叶酸缺乏组间血清Hcy水平比较，有统计学差异（P＜0.05）。结论：MTHFR 677基因多态性突变型占比较高，野生型占比较低。MTHFR杂合突变基因型（C677T）与纯合突变基因型（T677T）导致Hcy水平升高，T677T基因型合并叶酸缺乏更易导致血清Hcy水平升高，且叶酸缺乏者中男性较女性更易导致高Hcy血症。

参考文献/References:

[1] 〖ZK（#〗Wilcken DE，Wilcken B. The pathogenesis of coronary artery disease. A possible role for methionine metabolism [J] . Clin Invest，1976,57:10791082.
[2] Welch GN，Loscalzo. Homocysteine and atherothrombosis[J] . N Engl J Med， 1998，338:10421050 .
[3] Van der Put NM，Gabreels F，Stevens EM，et al.A second common mutation in the methylenetetrahydrofolate reductase gene：an additional risk factor for neuraltube defects? [J] .Am J Hum Genet，1998，62:10441051.
[4] 〖JP3〗Friedman G，Goldschmidt N，Friedlander Y，et al.A common mutation A1298C in human methylenetetrahydrofolate reductase gene：association with plasma total homocysteine and folate concentrations[J] . J Nutr，1999,129:16561661.〖JP〗
[5] Fratoni V，Brandi ML. B vitamins，homocysteine and bone health[J] . Nutrients,2015,7:21762192.
[6] Selhub J，Jacques PF，Dallal G，et al. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status[J] . Food Nutr Bull，2008,29:6773.
[7] Scazzone C，Bono A，Tornese F，et al. Correlation between low folate levels and hyperhomocysteinemia，but not with vitamin B12 in hypertensive patients[J] . Ann Clin Lab Sci，2014,44:286290.
[8] Holmes MV，Newcombe P，Hubacek JA，et al. Effect modification by population dietary folate on the association between MTHFR genotype，homocysteine，and stroke risk：a metaanalysis of genetic studies and randomised trials[J] . Lancet，2011,378:584594.
[9] 〖JP3〗Wilson CP，Mc Nulty H，Scott JM,et al. Postgraduate symposium：The MTHFR C677T polymorphism，Bvitamins and blood pressure[J] . Proc Nutr Soc，2010,69:156165.〖JP〗〖ZK)〗
[10] 〖ZK（#〗Mc Cully KS. Vascular pathology of homocysteinemia：implications for the pathogenesis of arteriosclerosis[J] .Am J Pathol，1969,56:111128.〖ZK)〗
[11] 〖ZK（#〗Boushey CJ，Beresford SAA，Omenn GS，et al.A quantitative assessment of plasma homocysteine as a risk factor for vascular disease probable benefits of increasing folic acid intakes[J] . JAMA，1995,274:10491057.
[12] Wald DS，Law M，Morris JK. Homocysteine and cardiovascular disease：evidence on causality from a metaanalysis[J] . BMJ，2002,325:1202.
[13] Wang Y，Li X，Qin X，et al. Prevalence of hyperhomocysteinaemia and its major determinants in rural Chinese hypertensive patients aged 45~75 years[J] . Br J Nutr，2013,109:12841293.〖ZK)〗〖JY〗〖HT〗(下转第1125页)〖FL)〗
[14] 〖ZK（#〗Wierzbicki AS. Homocysteine and cardiovascular disease：a review of the evidence[J] . Diab Vasc Dis Res，2007,4:143150.〖ZK）〗
[15] 〖ZK（#〗Iacobazzi V，Infantino V，Castegna A,et al. Hyperhomocysteinemia：related genetic diseases and congenital defects，abnormal DNA methylation and newborn screening issues[J] . Mol Genet Metab，2014,113:2733.〖ZK）〗
[16] 〖ZK（#〗Lai WK,Kan MY. Homocysteineinduced endothelial dysfunction[J] . Ann Nutr Metab，2015,67:112.〖ZK）〗
[17] 〖ZK（#〗李 华，黄娟娟. 亚甲基四氢叶酸还原酶基因677多态性与复发性流产相关性分析[J] .陕西医学杂志，2017,46(7):855857.〖ZK）〗
[18] 〖ZK（#〗马亚玲，吴海琴，张 萌，等．高同型半胱氨酸血症伴急性脑梗死患者周围神经传导速度临床观察[J] ．陕西医学杂志，2015,44(7):877878. 
[19] 米蔓丽，宋炎鑫，艾海权，等．亚甲基四氢叶酸还原酶基因多态性与原因不明复发性流产相关性的Meta分析[J] ．中国循证医学杂志，2016,16(8):897905.
[20] Mahalle N，Kulkarni MV，Garg MK,et al.Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease[J] . J Cardiol，2013,61:289294.

相似文献/References:

[1]李福泰,姚春虹△,慕廷民,等.急性脑梗死患者炎症因子与同型半胱氨酸、纤维蛋白原相关性研究*[J].陕西医学杂志,2019,(1):71.
　LI Futai,YAO Chunhong,MU Tingmin,et al.Correlation study between inflammatory factors andhomocysteine and fibrinogen in acute cerebral infarction patients[J].,2019,(9):71.
[2]李顺钧,王 慧,浦苏颖,等.急性脑梗死患者血清oxLDL、Hcy、LDL水平变化及检测临床意义[J].陕西医学杂志,2019,(5):664.
　LI Shunjun,WANG Hui,PU Suying,et al.Changes of oxLDL，Hcy and LDL levels in patients withcerebral infarction and their clinical significance[J].,2019,(9):664.
[3]贺龙梅,王 禺,王 凌,等.血清同型半胱氨酸、血浆纤维蛋白原与尿微量白蛋白联合检测预测脑梗死风险评估临床研究*[J].陕西医学杂志,2019,(7):903.
[4]宋红波.肾综合征出血热患者血清同型半胱氨酸、胱抑素C水平检测及临床意义*[J].陕西医学杂志,2019,(8):1085.
　SONG Hongbo..Detection of serum homocysteine level in patients with hemorrhagic fever with renal syndrome and its clinical significance[J].,2019,(9):1085.
[5]卫晓红,宋艳玲△.血浆同型半胱氨酸、C反应蛋白和低密度脂蛋白胆固醇水平与〖JZ〗脑梗死患者颅内动脉、颅外动脉狭窄相关性分析[J].陕西医学杂志,2019,(10):1366.
[6]刘玲娇,李 婧,闫 妮,等.健康体检职业人群中同型半胱氨酸水平影响因素分析*[J].陕西医学杂志,2020,49(9):1082.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.007]
　LIU Lingjiao,LI Jing,YAN Ni,et al.Influencing factors of homocysteine level in occupational population[J].,2020,49(9):1082.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.007]
[7]田 野,何亚军.急性心肌梗死经皮冠状动脉介入治疗患者血清同型半胱氨酸水平预测不良心血管事件的价值及其相关性分析[J].陕西医学杂志,2022,51(10):1223.[doi:DOI:10.3969/j.issn.1000-7377.2022.10.011]
　TIAN Ye,HE Yajun.Value of serum Hcy level in predicting adverse cardiovascular events in patients with acute myocardial infarction undergoing PCI intervention and its correlation analysis[J].,2022,51(9):1223.[doi:DOI:10.3969/j.issn.1000-7377.2022.10.011]

更新日期/Last Update: 2019-09-24