[1]周维纲,王宇波△,杨建治,等.右美托咪定对分娩镇痛产妇产程和脐动脉血气的影响*[J].陕西医学杂志,2019,(8):1074-1076.
　ZHOU Weigang,WANG Yubo,YANG Jianzhi,et al.Effect of dexmedetomidine on the duration of labor and umbilical artery blood gas in painless parturient[J].,2019,(8):1074-1076.
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右美托咪定对分娩镇痛产妇产程和脐动脉血气的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1074-1076
栏目:
药物与临床
出版日期:
2019-08-05

文章信息/Info

Title:
Effect of dexmedetomidine on the duration of labor and umbilical artery blood gas in painless parturient
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.032
作者:
周维纲1; 王宇波1△; 杨建治1; 郑名辉1; 王 燕1; 张汉湘1; 张建标2
1.陕西省汉中市中心医院 (汉中 723000）；2.汉中职业技术学院（汉中 723000）
Author(s):
ZHOU Weigang;  WANG Yubo; YANG Jianzhi;  et al.
Hanzhong Central Hospital,in Shaanxi Province（Hanzhong 723000）
关键词:
硬膜外镇痛; 产科; 右美托咪定;  产程;  脐动脉血气;  新生儿Apgar评分
Keywords:
Key words Epidural analgesia; Obstetrical; Dexmedetomidine;  Birth process;  Umbilical artery blood gas;  Newborn Apgar score
分类号:
R714.7
文献标志码:
A
摘要:
摘 要 目的：探讨右美托咪定对分娩镇痛产妇产程及脐动脉血气的影响。方法：分娩镇痛的足月（37～42孕周）初产妇90例，单胎、头位、ASAⅠ～Ⅱ级，年龄22～32岁，BMI<35 kg/m2，随机分为右美托咪定组（A组，n=45）和对照组（C组，n=45）。记录产妇入产房时（T1）、硬膜外注射负荷量后20 min (T2)、宫口开6～8 cm（T3）、宫口开全(T4)、胎儿娩出时（T5）的产妇视觉模拟评分（VAS）。记录第一产程（潜伏期、活跃期），第二产程，第三产程时限及催产素使用情况。胎儿娩出后行脐动脉血气分析。结果：与C组比较，A组产妇 T3 、T4 、T5 时间点VAS评分明显降低(P<0.05)；A组产妇T2、T3、T4、T5较T1时间点VAS评分明显降低(P<0.05)；C组产妇T2、T3、T4、T5较T1时间点VAS评分降低(P<0.05)；C组产妇T2、T4、T5时间点VAS评分明显高于T3(P<0.05)。两组产妇第一产程（潜伏期、活跃期）、第二产程、第三产程及催产素使用率，组间比较无统计学差异(P>0.05)。两组胎儿脐动脉血pH值、氧分压(PaO2)、二氧化碳分压(PaCO2)、碱剩余(BE)、乳酸（Lac），组间比较无统计学差异(P>0.05)。两组新生儿第1、5 min Apgar评分，组间比较无统计学差异(P>0.05)。结论：分娩镇痛时静脉辅助右美托嘧定是一种安全有效的方法。
Abstract:
Abstract Objective：To explore the effect of dexmedetomidine on the delivery duration and umbilical artery blood gas of painless parturient.Methods：Requirements of epidural term (37～42 gestational age) 90 cases of primipara, singletons, head, ASA Ⅰ～Ⅱ grade, age 22 to 32 years old, BMI＜35 kg/m2, were randomly divided into dexmedetomidine group (group A, n=45) and control group (group C,n=45).Visual simulation scores (VAS) were recorded when the woman entered the delivery room（T1）, 20min after epidural injection(T2), 6-8cm of the uterine orifice(T3), complete uterine opening(T4) and delivery of the fetus(T5).The duration of the first (latency, activity), second and third stage of labor was recorded, and the amount of oxytocin was recorded.Blood gas analysis of umbilical artery was performed after fetal delivery.Results：Compared with group C, the VAS scores of the T3, T4 and T5 time points of the parturients in group A were significantly reduced (P＜0.05).In group A, the VAS scores of T2, T3, T4 and T5 of the patients were significantly lower than T1 (P＜0.05).In group C, the VAS scores of T2, T3, T4 and T5 of the patients were lower than T1 (P＜0.05).The VAS scores of patients in group C at time points T2, T4 and T5 were significantly higher than T3 (P＜0.05).There was no statistical significant difference in terms of the first, second, and third stage of labor, and the amount of oxytocin used between the two group cases (P>0.05).There was no statistically significant difference in fetal umbilical arterial blood pH, PaO2, PaCO2, BE and lactate between the two groups(P>0.05).Apgar score at 1 min and 5 min in the two groups showed no statistically significant difference (P>0.05).Conclusion：Intravenous dexmedetomidine for labor analgesia is safe and effective adjuvant method.

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备注/Memo

备注/Memo:
*陕西省汉中市中心医院院级科研基金中标项目（YK17016）
更新日期/Last Update: 2019-08-13