[1]蒋永悟.妊娠贫血患者不同孕期血常规及凝血功能变化研究*[J].陕西医学杂志,2019,(8):1052-1055.
　JANG Yongwu..Blood routine and coagulation function in patients with gestational anemia during different pregnancy[J].,2019,(8):1052-1055.
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妊娠贫血患者不同孕期血常规及凝血功能变化研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1052-1055
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Blood routine and coagulation function in patients with gestational anemia during different pregnancy
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.026
作者:
蒋永悟
陕西省安康市妇幼保健院检验科（安康725000）
Author(s):
JANG Yongwu.
Clinical Laboratory of Ankang Maternal and Child Health Hospital(Ankang 725000)
关键词:
妊娠期; 贫血; 血常规; 凝血功能; 小细胞贫血; 大细胞贫血
Keywords:
Key words Pregnancy;  Anemia;  Blood routine;  Coagulation; Small cell anemia;  Large cell anemia
分类号:
R737.31
文献标志码:
A
摘要:
摘 要 目的：研究妊娠期贫血患者在不同孕期的血常规和凝血功能变化。 方法：选取产检并分娩的孕妇198例，其中孕早期22例，孕中期80例，孕晚期96例。对不同孕期患者的贫血类型进行分析，贫血类型包括小细胞贫血、大细胞贫血和其他贫血。对妊娠贫血患者不同孕期的血常规变化进行分析。对贫血患者不同孕期不同程度（轻度、中度和重度）贫血发生率进行分析。对妊娠贫血患者不同孕期的凝血功能变化进行分析。结果：不同孕期小细胞贫血、大细胞贫血的发生率存在统计学差异（P＜0.05），其他类型贫血的发生率比较，差异无统计学意义（P＞0.05）。不同孕期贫血类型比较，差异有统计学意义（P＜0.05），孕早期和孕中期主要以小细胞贫血为主，孕晚期以大细胞贫血为主。不同孕期贫血患者红细胞比容（HCT）、血红蛋白(Hb)、外周血红细胞（RBC）、平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）和平均红细胞血红蛋白浓度（MCHC）比较，差异有统计学意义（P＜0.05），其中孕中期贫血患者的HCT、Hb、RBC和MCHC水平显著低于孕早期（P＜0.05），孕晚期贫血患者的HCT、Hb、RBC、和MCHC均显著低于孕早期和孕中期（P＜0.05）。不同孕期贫血患者轻度贫血和中度贫血的发生率比较，差异有统计学意义（P＜0.05），孕早期均为轻度贫血，孕中期和孕晚期轻度贫血发生率均呈下降趋势。不同孕期的贫血发生率比较，差异有统计学意义（P＜0.05）。不同孕期贫血患者的活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）水平比较，差异有统计学意义（P＜0.05）。孕中期贫血患者APTT、TT水平显著低于孕早期（P＜0.05）。孕晚期贫血患者的APTT、PT和TT显著低于孕早期和孕中期（P＜0.05），纤维蛋白原（FIB）显著高于孕早期和孕中期（P＜0.05）。结论： 针对妊娠贫血患者，应进行血常规及凝血功能的连续检测，以有利于调整营养方案，防止贫血及其他妊娠期并发症的发生或加重，进而减少不良妊娠结局的发生。
Abstract:
Abstract Objective: The blood routine and coagulation function of pregnant patients with anemia during pregnancy were studied. Methods:198 pregnant women for childbirth and delivery were selected，including 22 in early pregnancy，80 in the second trimester，and 96 in the third trimester. Analysis of anemia types in patients with different pregnancies were conducted，including anemia，small cell anemia，and other anemias. Routine blood changes in pregnant women with anemia during pregnancy were measured. The incidence of anemia of different degrees (mild，moderate and severe) in different stages of anemia was analyzed.Coagulation function changes in different stages of pregnancy in patients with anemia were analyzed. Results:There was a significant difference in the incidence of small cell anemia and large cell anemia between different stages of pregnancy (P＜0.05). There was no significant difference in the incidence of other types of anemia (P＞0.05).There were significant differences in the types of anemia between different stages of pregnancy (P＜0.05). In the early pregnancy and the second trimester,small cell anemia was the main cause，and in the third trimester，large cell anemia was the main cause.The levels of HCT，Hb，RBC and MCHC in patients with anemia during pregnancy were significantly different (P＜0.05). The levels of HCT，Hb，RBC and MCHC in patients with anemia in the second trimester were significantly lower than those in the first〖LM〗 trimester (P＜0.05). HCT，Hb，RBC，and MCHC were significantly lower in the third trimester than those in the first trimester and the second trimester (P＜0.05). The incidence of mild anemia and moderate anemia in patients with anemia during pregnancy was significantly different (P＜0.05)，mild anemia in the first trimester，and mild anemia in the second trimester and third trimester. There was a significant difference in the incidence of anemia between different stages of pregnancy (P＜0.05). The levels of APTT，PT and TT in patients with anemia during pregnancy were significantly different (P＜0.05). The levels of APTT and TT in patients with anemia during the second trimester were significantly lower than those in the first trimester (P＜0.05). The APTT，PT and TT of patients with anemia in the third trimester were significantly lower than those in the first trimester and the second trimester (P＜0.05). FIB was significantly higher than that in the first trimester and the second trimester (P＜0.05).Conclusion： For patients with anemia of pregnancy，continuous testing of blood routine and coagulation function should be carried out to adjust the nutritional program and prevent the occurrence or aggravation of anemia and other complications during pregnancy，thereby reducing the occurrence of adverse pregnancy outcomes.

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备注/Memo

备注/Memo:
*陕西省科学技术研究发展计划项目（2011K12-60）
更新日期/Last Update: 2019-08-13