[1]王荣锋,郁 昊,蒋新建.老年糖尿病患者血清25羟维生素D水平与骨质疏松相关性研究[J].陕西医学杂志,2019,(8):1032-1034,1041.
　WANG Rongfeng,YU Hao,JIANG Xinjian..The relationship between serum 25 hydroxy vitamin D and osteoporosis in elderly diabetic patients[J].,2019,(8):1032-1034,1041.
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老年糖尿病患者血清25羟维生素D水平与骨质疏松相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1032-1034,1041
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
The relationship between serum 25 hydroxy vitamin D and osteoporosis in elderly diabetic patients
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.020
作者:
王荣锋1; 郁 昊1; 蒋新建2
1.四川友谊医院（成都 610000）;2.成都市第二人民医院（成都 610000）
Author(s):
WANG Rongfeng;  YU Hao;  JIANG Xinjian.
Sichuan Friendship Hospital（Chengdu 610000）
关键词:
老年人; 2型糖尿病; 骨质疏松; 25羟维生素; 骨密度; 相关性
Keywords:
Key words Aged; Type 2 diabetes mellitus; Osteoporosis; 25-hydroxy vitamin D; Bone mass density; Relevance
分类号:
R584
文献标志码:
A
摘要:
摘 要 目的：探讨老年2型糖尿病患者(T2DM)血清25羟维生素\[25(OH)D\]水平与骨质疏松程度的相关性。方法：选取2型糖尿病老年患者152例为观察组，选择相同时间段体检的150例健康体检的老年人为对照组，采用美国GE双能X线骨密度仪测定所有对象腰椎L2～L4和左侧股骨近端：股骨颈(Neck)、大转子(Troch)、沃氏三角区(Ward’s)的骨密度(BMD)值，依据BMD将观察组患者分为三个亚组：骨质疏松组、骨量减少组和骨量正常组。酶联免疫分析法(ELISA)测定血清25(OH)D水平，分析25(OH)D水平与骨质密度的相关性。结果：与对照组比，观察组血清25(OH)D和各个部位的BMD均明显降低(P＜0.05)，观察组患者骨质疏松82例、骨量减少50例和骨量正常20例。观察组骨质疏松发病率为53.95%(82/152)。与对照组比，观察组三个亚组的血清25(OH)D和各个部位的BMD均有不同程度地降低(P＜0.05)，25(OH)D水平、BMD与骨质疏松的关系观察组呈负相关(均P＜0.05)，随着BMD的升高，25(OH)D水平的增加，骨质疏松的程度越低(均P＜0.05)。血清25(OH)D和BMD降低是老年糖尿病患者发生骨质疏松危险因素(均P＜0.05)。结论：老年糖尿病患者骨质疏松发病率较高，血清25(OH)D水平与骨质疏松程度呈正相关，血清25(OH)D水平可为临床诊断骨质疏松提供参考。
Abstract:
Abstract Objective：To explore investigate the relationship between the level of serum 25 hydroxy vitamin D and the degree of osteoporosis in elderly patients with type 2 diabetes mellitus (T2DM). Methods：152 cases of elderly patients with T2DM were selected as the observation group. The 150 elderly people who had physical examination at the same time were selected as the control group. Bone mineral density (BMD) of lumbar L2～L4 and left proximal femur (including Neck, Troch and Ward triangular areas) were measured in all patients with the US Hologic dual energy X-ray bone density detector. According to bone mineral density, the observation groups were divided into 3 subgroups:osteoporosis group, osteopenia group and normal bone mass group. The enzyme-linked immunosorbent assay (ELISA) was used to determine serum 25(OH)D,the correlation between 25(OH)D level and BMD were analyzed. Results:Compared with the control group, serum 25(OH)D and BMD in all the observation groups were significantly lower (P＜0.05). In the observation group, 82 patients in the osteoporosis group, 50 cases in the bone loss group and 20 cases in the normal bone mass group. The incidence of osteoporosis in the observation group was 53.95% (82/152). Compared with the control group, the serum 25(OH)D and BMD in the observation group had decreased to different extents (P＜0.05). The 25(OH)D and BMD were negatively connected with the osteoporosis(P＜0.05). With the increase of BMD, the level of 25(OH)D had increased and the degree of osteoporosis had decreased(P＜0.05). The reduction of the serum 25(OH)D and BMD were risk factors of the osteoporosis in elderly T2DM patients(P＜0.05).Conclusion：The incidence of osteoporosis in elderly T2DM patients is high. The level of serum 25 (OH) and BMD is positively related to the degree of osteoporosis. Serum 25 (OH) level can provide an effective reference for the clinical diagnosis of osteoporosis.

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更新日期/Last Update: 2019-08-13