[1]沈 健,张雨涵,曹芳蕾,等.强直性脊柱炎患者血清RANKL、TGF-β1和TGF-β2的表达及临床意义[J].陕西医学杂志,2019,(8):981-983.
　SHEN Jian,ZHANG Yuhan,CAO Fanglei,et al.Clinical significance of RANKL, TGF-β1 and TGF-β2 in ankylosing spondylitis[J].,2019,(8):981-983.
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强直性脊柱炎患者血清RANKL、TGF-β1和TGF-β2的表达及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
981-983
栏目:
基础研究
出版日期:
2019-08-05

文章信息/Info

Title:
Clinical significance of RANKL, TGF-β1 and TGF-β2 in ankylosing spondylitis
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.08.005
作者:
沈 健1; 张雨涵1 ; 曹芳蕾1;  郗萌萌
1.锦州医科大学附属第三医院风湿免疫科(锦州 121001);2.辽宁省锦州市妇婴医院(锦州121001)
Author(s):
SHEN Jian; ZHANG Yuhan; CAO Fanglei; et al.
Department of Rheumatic Immunology,  Third Affiliated Hospital, Jinzhou Medical University(Jinzhou 121001)
关键词:
强直性脊柱炎; 细胞核因子-κB受体活化因子配体; 转化生长因子β1; 转化生长因子β2; 标志物; 对照研究
Keywords:
Ankylosing spondylitis;  Receptor activator of nuclear factor κB ligand;  Transforming growth factor-β1;  Transforming growth factor-β2;  Symbols;  Control study
分类号:
R593.23
文献标志码:
A
摘要:
摘 要 目的：观察强直性脊柱炎患者血清中细胞核因子-κB受体活化因子配体(RANKL)、转化生长因子β1（TGF-β1）和转化生长因子β2（TGF-β2）表达水平，探讨其临床意义。方法:选择202例强直性脊柱炎患者作为观察组，选择98例健康成人的血清标本作为对照组。收集受试者血清标本，应用ELISA法检测两组血清中RANKL、TGF-β1和TGF-β2的表达。结果:两组血清中RANKL、TGF-β1和TGF-β2的表达差别有统计学意义。RANKL、TGF-β1和TGF-β2的表达与在不同骨侵蚀关节个数及附着点炎关节个数中的表达差别有统计学意义。相关分析显示观察组中强直性脊柱炎患者血清中RANKL和TGF-β1、RANKL和TGF-β2、TGF-β1和TGF-β2之间的表达具有正相关性。结论：RANKL、TGF-β1和TGF-β2在强直性脊柱炎高表达，对病变的形成和进展具有重要作用，三者之间具有正相关性。联合检测血清中RANKL、TGF-β1和TGF-β2的表达可能成为强直性脊柱炎的早期诊断标志物。
Abstract:
Abstract Objective：To observe the expression levels of RANKL, TGF-β1 and TGF-β2 in patients with ankylosing spondylitis, analyze their clinical significance. Methods：202 patients with ankylosing spondylitis were selected as observation group, 98 healthy adults were selected as control group. Serum expressions of RANKL, TGF-β1 and TGF-β2 were detected by ELISA in two groups. Results： Expressions of RANKL, TGF-β1 and TGF-β2 were statistical different in two groups. Expressions of RANKL, TGF-β1 and TGF-β2 were significantly different in different bone erosion joints and attachment arthritis joints. There were positive correlation between RANKL and TGF-β1,RANKL and TGF-β2, TGF-β1 and TGF-β2 in the observation group. Conclusion：The high expression of RANKL, TGF-β1 and TGF-β2 plays an important role in the formation and progression of lesions in ankylosing spondylitis. There were positive correlation between RANKL, TGF-β1 and TGF-β2. Combined detection of RANKL, TGF-β1 and TGF-β2 may be an early diagnostic marker of ankylosing spondylitis, which may be related to the mechanism that ankylosing spondylitis is an inflammatory disease.

参考文献/References:

[1] 许敬人, 张春燕, 茅惠明,等. 补肾通督方对强直性脊柱炎患者血清TNF-α、TGF-β1及骨代谢的影响[J]. 上海中医药大学学报, 2008, 22(1):33-35.
[2] Perpetuo IP, Caetano-Lopes J, Vieira-Sousa E, et al. Corrigendum: ankylosing spondylitis patients have impaired osteoclast gene expression in circulating osteoclast precursors[J]. Frontiers Med, 2017, 4(10):38-39.
[3] 蔡余力, 张兴彩, 张厚君,等. 补肾通阳法调节强直性脊柱炎患者TNF-α和TGF-β1的研究[J]. 中医药学报, 2017, 45(3):70-73.
[4] 朱元悦, 张 玲, 孙 柔, 等. 强直性脊柱炎患者外周血T细胞亚群及相关免疫分子的变化[J]. 现代免疫学, 2017, 34(1):14-19.
[5] Fan J, Zhao J, Shao J, et al. I-BET151 inhibits expression of RANKL, OPG, MMP3 and MMP9 in ankylosing spondylitis in vivo and in vitro[J]. ExpTherap Med, 2017, 14(5):4602-4606.
[6] 张 征, 孙其桓, 白 晶,等. 活动性强直性脊柱炎患者外周血MIF、IL-23、RANKL、OPG和DKK1检测的临床意义[J]. 河北医药, 2018, 40(2):178-182.
[7] Hu Z, Lin D, Qi J, et al. Serum from patients with ankylosing spondylitis can increase PPARD, fra-1, MMP7, OPG and RANKL expression in MG63 cells[J]. Clinics, 2015, 70(11):738-742.
[8] 周绮红. 鹿瓜多肽中骨诱导多肽类生物因子在临床中应用[J].中国伤残医学, 2017, 25(18):100-101.
[9] 李晓丽, 刘玲玲, 赵 龙, 等. 2型糖尿病患者血浆TGF-β 1 水平及其与心脏结构和功能的关系[J]. 江苏大学学报: 医学版, 2015, 34(4): 317-321.
[10] 高 巍, 武 忠, 李敏州, 等. 中医药基于TGF-β1治疗糖尿病肾病研究概况[J]. 中医药临床杂志, 2017, 29(2): 164-167.
[11] Layhschmitt G, Lu S, Navid F, et al. Generation and differentiation of induced pluripotent stem cells reveal ankylosing spondylitis risk gene expression in bone progenitors[J]. Clin Rheumatol, 2017, 36(1):143-154.
[12] Mou YK, Zhang PP, Li QX, et al. Changes of serum levels of MMP-3, sRANKL, and OPG in juvenile-onset ankylosing spondylitis patients carrying different HLA-B27 subtypes[J]. Clinical Rheumatology, 2015, 34(6):1085-1089.
[13] Luo H. Serum OPG and sRANKL in evaluating the disease activity of ankylosing spondylitis[J]. Acta Universitatis Medicinalis Nanjing, 2011, 31(10):1455-1458.
[14] Mcgarry F, Cousins L, Sturrock RD, et al. A polymorphism within the Transforming Growth Factor β1 gene is associated with ankylosing spondylitis (AS)[J]. Arthritis Research, 2002, 4(1):22-23.
[15] 邵景韫, 戚好文, 刘 安,等. 胸腔积液中TGF-β1、VEGF、bFGF、PAI-1的检测及其临床意义[J].陕西医学杂志, 2006, 35(1):100-101.
[16] 时代音,胡春婷,何 娅.黄芪汤对酒精性肝纤维化大鼠TNF-α及TGF-β1的影响[J]. 陕西中医, 2011, 32(6):758-759.
[17] 许敬人,张春燕,李伟民,等.补肾通督方对强直性脊柱炎血清TNF-α及TGF-β1水平的影响[J].中国中西医结合杂志, 2008, 28(12):1093-1095.

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更新日期/Last Update: 2019-08-13