[1]白 璐.多烯磷脂酰胆碱对急性黄疸型肝炎患者肝功能的影响研究[J].陕西医学杂志,2019,(7):933-935.
　BAI Lu..Effect of polyene phosphatidylcholine on liver function in patients with acute jaundice hepatitis[J].,2019,(7):933-935.
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多烯磷脂酰胆碱对急性黄疸型肝炎患者肝功能的影响研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年7期
页码:
933-935
栏目:
药物与临床
出版日期:
2019-07-05

文章信息/Info

Title:
Effect of polyene phosphatidylcholine on liver function in patients with acute jaundice hepatitis
文章编号:
DOI:10.3969/j.issn.1000-7377.2019.07.034
作者:
白 璐
锦州医科大学附属第三医院消化科（锦州 121000）
Author(s):
BAI Lu.
Department of Gastroenterology,The Third Affiliated Hospital of Jinzhou Medical University(Jinzhou 121000)
关键词:
急性黄疸型肝炎; 多烯磷脂酰胆碱;  保肝治疗; 肝功能;  不良反应; 影响
Keywords:
Key words Acute jaundice hepatitis; Polyene phosphatidylcholine;  Hepatoprotective therapy;  Liver function; Adverse reactions; Influences
分类号:
R512.61
文献标志码:
A
摘要:
摘 要 目的:探究多烯磷脂酰胆碱在治疗急性黄疸型肝炎的临床疗效。方法:80例急性黄疸型肝炎患者按照随机数字法分为两组。对照组40例给予常规保肝治疗，治疗组40例在常规保肝治疗基础上联合应用多烯磷脂酰胆碱，观察两组在治疗前后的症状体征及肝功能指标的变化。结果:治疗后两组患者肝功能指标谷草转氨酶（AST）、谷丙转氨酶（ALT）、总胆红素（TBiL）水平均显著降低，且治疗组的上述指标改善情况明显优于对照组；治疗后，两组患者厌食、乏力、腹胀、肝区不适等临床症状均有明显的改善，治疗组临床症状评分显著优于对照组（P＜0.05）；治疗后4周两组白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均显著降低，且治疗组下降更明显（P＜0.05）；治疗组总有效率（95.0%）显著高于对照组（P＜0.05）。结论:多烯磷脂酰胆碱治疗急性黄疸型肝炎有较好的临床效果，无明显不良反应。
Abstract:
Abstract Objective:To explore the clinical efficacy of polyene phosphatidylcholine in the treatment of acute jaundice hepatitis. Methods:80 patients with acute jaundice hepatitis were randomly divided into two groups. 40 cases in the control group were treated with routine hepatoprotective therapy，while 40 cases in the observation group were treated with polyene phosphatidylcholine on the basis of routine hepatoprotective therapy. The changes of symptoms，signs and liver function indexes in the two groups were observed before and after treatment. Results:After treatment，the ALT，AST and TBiL levels of the two groups were significantly reduced，and the improvement of the above indicators in the observation group was significantly better than that in the control group; after treatment，the clinical symptoms of anorexia，abdominal distension，fatigue，liver discomfort in the two groups were significantly improved，and the clinical symptom score in the observation group was significantly better than that in the control group (P＜0.05); After 4 weeks of treatment，the levels of IL-6 and TNF-alpha in the two groups were significantly decreased，and the decrease in the observation group was more obvious (P＜0.05)；The total effective rate in the observation group (95.0%) was significantly higher than that in the control group (P＜0.05). Conclusion:Polyene phosphatidylcholine has a good clinical effect in treating acute jaundice hepatitis，and has no obvious adverse reactions. It is worthy of clinical promotion and application.

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更新日期/Last Update: 2019-07-12