[1]宗 伟,李玉龙,万兵兵,等.内镜逆行胰胆管造影术后出血危险因素分析*[J].陕西医学杂志,2019,(6):774-777.
 ZONG Wei,LI Yulong,WAN Bingbing,et al.Risk factors of post endoscopic retrograde cholangiopancreatography hemorrhage[J].,2019,(6):774-777.
点击复制

内镜逆行胰胆管造影术后出血危险因素分析*
分享到:

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年6期
页码:
774-777
栏目:
临床研究
出版日期:
2019-06-05

文章信息/Info

Title:
Risk factors of post endoscopic retrograde cholangiopancreatography hemorrhage
文章编号:
DOI:〖HT5K〗10.3969/j.issn.1000-7377.2019.06.025
作者:
宗 伟1李玉龙1万兵兵1吴武军
1.陕西省人民医院消化内一科(西安 710068);2.陕西省人民医院肝胆外科(西安 710068)
Author(s):
ZONG Wei LI Yulong WAN Bingbing et al.
Department of Gastroenterology,Shaanxi Provincial People's Hospital(Xi’an 710068)
关键词:
出血 内镜逆行胰胆管造影术(ERCP) 危险因素 病例对照研究
Keywords:
Key words HemorrhageEndoscopic retrograde cholangiopancreatography Risk factors
分类号:
R575
文献标志码:
A
摘要:
摘 要 〖HT5K〗目的:探讨内镜逆行胰胆管造影术(ERCP)后出血的危险因素。方法:收集行ERCP术后并发出血的患者(出血组)43例,按1∶2的比例匹配在年龄、性别相近的ERCP术后未出血的患者86例作为对照组;分析比较两组患者在原发疾病、术中操作步骤等因素,选择单因素分析中P<0.05的因素作为潜在危险因素,进一步行多因素分析。结果:单因素分析结果显示:胆总管结石、括约肌预切开、括约肌大切开、球囊取石术、鼻胆引流管因素在出血组与对照组中均有统计学差异。将上述因素进行逻辑回归多因素分析显示:括约肌大切开(OR 3.245,95%CI 1.210~8.699)、括约肌预切开(OR 3.957,95%CI 1.395~11.223)、球囊取石 (OR 3.492,95%CI 1.371~8.898)为ERCP术后出血独立的风险因素。结论:括约肌大切开、括约肌预切开、球囊取石可能增加ERCP术后出血风险。
Abstract:
Abstract Objective:Post-Endoscopic Retrograde Cholangiopancreatography (ERCP)bleeding is one of the severe complications . and the risk factors for this condition have not yet been clearly evaluated . The current study aimed to investigate the risk factors of post-ERCP bleeding. Methods:The hemorrhage group consists of 43 patients who experienced post-ERCP bleeding whereas the control group has 86 patients matched for age and gender who have not experienced post-ERCP bleeding. We compared protopathy (e.g. Choledocholithiasis), technical (e.g.Long-incision of sphincter) factors between these two groups. Results:There were significant difference between the hemorrhage and the control group in choledocholithiasis, pre-cut of sphincter, long-incision of sphincter, balloon catheter stone extraction, endoscopic nasobilary. In logistic regression: pre-cut of sphincter(OR3.957, 95%CI1.395~11.223), long-incision of sphincter (OR 3.245, 95%CI 1.210~8.699), balloon catheterextraction (OR3.492, 95%CI1.371~8.898) were independent risk factors of post-EST bleeding. Conclusion:The current study illuminated that long-incision of sphincter, pre-cut of sphincter, balloon catheterextraction raise the likelihood of post-ERCP bleeding, therefore doctors and nurses should identify those patients with high risks and do things to prevent such.

参考文献/References:

[1] Freeman ML, Nelson DB, Sherman S, et al. Complications of endoscopic biliary sphincterotomy[J]. N Engl J Med, 1996, 335:909-918.
[2] 徐洪根,马 进.治疗性ERCP术后十二指肠乳头出血与原发疾病的关系[J].世界华人消化杂志, 2017,25(8):755-759.
[3] Kim Ko ,Kim TN, Kim SB,et al. Characteristics of delayed hemorrhage after endoscopic sphincterotomy[J]. Journal of Gastroenterology and Hepatology, 2010, 25(3):532-538.
[4] Liu F, Wang GY, Li ZS,et al.Cap-assisted hemoclip application with forward-viewing endoscope for hemorrhage induced by endoscopic sphincterotomy: a prospective case series study[J] BMC Gastroenterol,2015,15:135.
[5] Oh HC,Eihajj L,Easler JJ,et al.Post-ERCP bleeding in the era of multiple antiplatelet agents[J]. Gut Liver,2018,12(2):214-218.
[6] Park BG, Yoo YW, Song JC,et al.Successful management of periampullary diverticular bleeding with hemoclipping using side-viewing endoscope during Endoscopic retrograde cholangiopancreatography[J] Korean J Gastroenterol,2016,67(3):146-149.
[7] Martin L, Freeman MD, Douglas B,et al. Complications of endoscopic biliary sphincterotomy[J]. The New England Journal of Medicine, 1996, 335:909-919.
[8] Lee MH, Tsou YK, Lin CH,et al.Predictors of re-bleeding after endoscopic hemostasis for delayed post-endoscopicsphincterotomy bleeding[J] World J Gastroenterol,2016,22(11):196-201.
[9] Okuno M, Adachi S, Horibe Y,et al.Bile duct injury and severe bleeding after endoscopic papillary large balloon dilation without sphincterotomy: a case report[J]. Nihon Shokakibyo Gakkai Zasshi,2016,113(4):672-679.
[10] Leung WK, But DY, Wong SY,et al. Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial[J] J Digestive Diseases,2018,19(6):369-376.
[11] Freeman ML. Adverse outcomes of ERCP[J]. Gastrointest Endosc, 2002, 56:S273-S282.
[12] ASGE Standards of Practice Committee, Chandrasekhara V, Khashab MA,et al.Adverse events associated with ERCP[J] Gastrointest Endosc,2017,85(1):32-47.
[13] Chon HK, Kim TH,et al.Endoclip therapy of post-sphincterotomy bleeding using a transparent cap-fitted forward-viewing gastroscope[J].Surg Endosc,2017 ,31(7):2783-2788.
[14] Goff JS. Common bile duct pre-cut sphincterotomy: transpancreatic sphincter approach[J]. Gastrointest Endosc, 1995, 41(5):502-505.
[15] Alberca de Las,Parras F, Egea Valenzuela J, et al. Bleeding risk in endoscopic retrograde cholangiopancreatography. Impact of the use of antithrombotic drugs[J] Rev Esp Enferm Dig,2017,109(3):202-210.
[16] Plewka M, Rysz J, Kujawski M,et al. Complications of endoscopic retrograde cholangiopancreatography[J] Pol Merkur Lekarski,2017,43(258):272-275.
[17] 宗 伟,俞 晨,崔建辉,等.吲哚美辛栓直肠给药预防ERCP术后胰腺炎的临床分析[J].陕西医学杂志,2014,43(8): 984-985.
[18] Yasuda M, Sato H, Koyama Y,et al.Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion[J] World J Gastroenterol,2017,23(4):735-739.
[19] Cho JM, Jeong IS, Kim HJ,et al.Early adverse events and long-term outcomes of endoscopic sphincterotomy in a pediatric population: a single-center experience[J].Endoscopy, 2017,49(5):438-446.
[20] Shen YH, Yang LQ, Yao YL, et al.Dilation Time in endoscopic papillary balloon dilation for common bile duct stones[J]. Surg Laparosc Endosc Percutan Tech,2017,27(5):351-355.
[21] Al-Akwaa AM, Elsadig M, Al-Fayaa AE,et al. Portal hypertensive biliopathy presents with massive bleeding during ERCP after balloon sphincteroplasty in a noncirrhotic saudi sickler patient[J]. Case Report in Medicine,2017,5:1-4.
[22] Afiridi F, Rotunto L,Feundean M,et al.Trends in post-therapeutic endoscopic retrograde cholangiopancreatography gastrointestinal hemorrhage, perforation and mortality from 2000 to 2012: A nationwide study[J].Digestion, 2018, 22(18):1-9.
[23] Zhu Y,Wang S,Zhao S,et al.Obstructive jaundice due to a blood clot after ERCP: a case report and review of the literature[J].BMC Gastroenterol, 2018,18(1):163.

备注/Memo

备注/Memo:
*陕西省青年科技新星项目(2011KJXX26)
更新日期/Last Update: 2019-06-20