[1]金碧辉.霉酚酸脂治疗乙肝相关肾小球疾病疗效及对患者24 h尿蛋白、血清白蛋白临床研究[J].陕西医学杂志,2019,(4):512-514.
　JIN Bihui..Effect of mycophenolate lipid on hepatitis B related glomerular disease and influence on 24 h urine protein (UPO) and serum albumin (Alb)[J].,2019,(4):512-514.
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霉酚酸脂治疗乙肝相关肾小球疾病疗效及对患者24 h尿蛋白、血清白蛋白临床研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年4期
页码:
512-514
栏目:
药物与临床
出版日期:
2019-04-05

文章信息/Info

Title:
Effect of mycophenolate lipid on hepatitis B related glomerular disease and influence on 24 h urine protein (UPO) and serum albumin (Alb)
文章编号:
DOI: 10.3969/j.issn.10007377.2019.04.030
作者:
金碧辉
内蒙古自治区赤峰市医院肾内科（赤峰 024000）
Author(s):
JIN Bihui.
Department of Kidney Medicine Chifeng City Hospital in,Inner Mongolia （Chifeng 024000）
关键词:
霉酚酸脂; 乙肝; 肾小球疾病; 24 h尿蛋白; 血清白蛋白; 疗效观察
Keywords:
Key words Mycophenolate;  Hepatitis B;  Glomerular disease;  24 h Urine protein;  Serum albumin ; Therapeutic effect〖HJ1〗
分类号:
R512.6+2
文献标志码:
A
摘要:
摘 要 目的：观察霉酚酸脂治疗乙肝相关肾小球疾病疗效及对24 h尿蛋白(UPO)、血清白蛋白(Alb)的影响。方法：选取100例乙肝病毒相关性肾小球肾炎患者，随机分为对照组（n=50）与治疗组（n=50），对照组采用常规西药治疗，治疗组在常规西药治疗基础上添加霉酚酸脂治疗。对两组患者的临床疗效进行比较。结果：治疗组临床治疗效果、UPO、Alb测量情况均优于对照组，差异有统计学意义(P＜0.05)。两组患者不良反应发生情况比较，差异无统计学意义(P＞0.05)。治疗组治疗后3个月、6个月HBVDNA阴性率、HBeAg转阴率均高于对照组，差异有统计学意义(P＜0.05)，但治疗后12个月时两组比较差异无统计学意义（P>0.05）。结论：霉酚酸脂治疗乙肝相关肾小球疾病具有显著效果，应用价值较高。
Abstract:
Abstract Objective: To observe the effect of mycophenolate lipid on hepatitis B related glomerular disease and influence on 24h urine protein (UPO) and serum albumin (Alb). Methods: 100 patients with hepatitis B virusassociated glomerulonephritis were selected and randomly divided into control group (n=50) and observation group (n=50). The control group received conventional western medicine treatment, and the observation group received mycophenolate mofetil treatment on the basis of conventional western medicine treatment. The clinical efficacy of the two groups of patients was compared.Results: The clinical treatment effect, UPO、Alb measurement were better than the control group, and the difference was significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The HBVDNA negative rate and HBeAg negative rate in the observation group were higher than those in the control group at 3 months and 6 months after treatment, the difference was significant (P<0.05), but there was no significant difference between the two groups at 12 months after treatment (P<0.05). Conclusion: Mycophenolate mofetil has significant effects in the treatment of hepatitis B related glomerular diseases, and its application value is high.

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更新日期/Last Update: 2019-04-10