[1]陈孔博,邵 元.更昔洛韦联合神经节苷脂治疗病毒性脑炎疗效及对患者血清和脑脊液指标的影响*[J].陕西医学杂志,2019,(4):505-507，517.
　CHEN Kongbo,SHAO Yuan..Efficacy of ganciclovir combined with ganglioside in the treatment of viral encephalitis and its influence on serum and cerebrospinal fluid index[J].,2019,(4):505-507，517.
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更昔洛韦联合神经节苷脂治疗病毒性脑炎疗效及对患者血清和脑脊液指标的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年4期
页码:
505-507，517
栏目:
药物与临床
出版日期:
2019-04-05

文章信息/Info

Title:
Efficacy of ganciclovir combined with ganglioside in the treatment of viral encephalitis and its influence on serum and cerebrospinal fluid index
文章编号:
DOI: 10.3969/j.issn.10007377.2019.04.028
作者:
陈孔博; 邵 元
陕西省铜川矿务局中心医院神经内科（铜川 727000）
Author(s):
CHEN Kongbo ; SHAO Yuan.
Department of Internal Neurology, Central Hospital of Tongchuan Mining Bureau, Shaanxi Province(Tongchuan 727000)
关键词:
病毒性脑炎; 更昔洛韦; 抗病毒治疗; 神经节苷脂; 营养神经; 对比研究
Keywords:
Key words Viral encephalitis;  Ganciclovir;  Antiviral treatment; Ganglioside; Nutritional nerve; Comparative study
分类号:
R373.3+1
文献标志码:
A
摘要:
摘 要 目的：探讨更昔洛韦联合神经节苷脂治疗病毒性脑炎的疗效及对患者血清和脑脊液指标的影响。方法：98例病毒性脑炎患者按照治疗先后分为单一用药组（n=49）和联合用药组（n=49），患者入院后均给予对症治疗，单一用药组同时给予5 mg/kg更昔洛韦+100 ml 5%葡萄糖溶液抗病毒治疗，联合用药组在单一用药组基础上加用40 mg神经节苷脂+250 ml5%葡萄糖溶液神经营养治疗，两组均用药14 d。观察治疗效果及临床症状体征的恢复时间，并分析治疗前、后两组血清相关指标（NSE、MBP、S100β蛋白）、脑脊液相关指标（蛋白定量、单核细胞数、总细胞数）水平。结果：联合用药组患者临床症状、体征恢复时间显著短于单一用药组（P<0.05），治疗有效率明显高于单一用药组（P<0.05）；两组治疗后血清及脑脊液相关指标均获得明显改善（P<0.05），且联合用药组血清NSE、MBP、S100β蛋白水平均显著低于单一用药组血清（P<0.05），脑脊液中蛋白定量及总细胞数水平均显著低于单一用药组血清（P<0.05），两组均无明显不良反应发生。结论：病毒性脑炎患者给予对症治疗、抗病毒治疗的同时加用神经节苷脂对神经损伤给予针对性的治疗有利于患者的治疗和预后，安全可靠。
Abstract:
Abstract Objective: To investigate the efficacy of ganciclovir combined with gangliosides in the treatment of viral encephalitis and its impact on serum and cerebrospinal fluid indicators .Methods: According to the treatment,98 patients were divided into single medication group (n=49) and combination medication group (n=49) . Patients were treated with symptomatic treatment after admission. The single drug group was given 5 mg/kg ganciclovir + 100 ml 5% glucose solution for antiviral treatment, The combination group was given neurotrophic therapy with 40 mg ganglioside + 250 ml 5% glucose solution on the basis of single drug group. Both groups were given 14 d. Observe the treatment effect and the recovery time of clinical symptoms and signs, analyze the serum related indexes (NSE, MBP, S100β protein) and cerebrospinal fluid related indexes (protein quantification, monocyte count, total cell number) before and after treatment.Results: The recovery time of clinical symptoms and signs in the combination group was significantly shorter than that in the single drug group (P<0.05), and the treatment efficiency was significantly higher than that in the single drug group (P<0.05). The serum and cerebrospinal fluid related indexes were significantly improved after treatment (P<0.05), and the levels of serum NSE, MBP, and S100β protein in the combination group were significantly lower than those in the single drug group (P<0.05). The protein quantification and total cell number in the cerebrospinal fluid were significantly lower than those in the single drug group ( P<0.05), no significant adverse reactions occurred in either group.Conclusion: In patients with viral encephalitis, symptomatic treatment and antiviral therapy combined with gangliosides for targeted treatment of nerve injury are beneficial to the treatment and prognosis of patients, safe and reliable, and worthy of clinical promotion.

参考文献/References:

[1] 李 慧，刘 威，赵建民.2015-2016年病毒性脑炎流行病学分析[J].中国病原生物学杂志，2018,13（1）：72-75.
[2] 卢彦宏. 不同药物联合应用在小儿病毒性脑炎中的疗效观察及对部分指标的影响分析[J].现代诊断与治疗，2015,26（21）：4852-4853.
[3] 李玲玲，尤祥宇.神经节苷脂与脑发育[J].生物化工，2017,3（5）：90-94.
[4] 黄祥杏. 亚低温临河咪达唑仑治疗小儿重症病毒性脑炎的效果研究[J]. 临床与实践，2018,16（12）：34-35.
[5] 邵亚望，沈开慧，张孟孝，等. 更昔洛韦配伍干扰素治疗小儿病毒性脑炎102例效果评价[J]. 陕西医学杂志，2016,45（9）：1243-1244.
[6] 许秀金，宋 静，林进生，等. 纳洛酮联合更昔洛韦治疗小儿病毒性脑炎的研究[J]. 齐齐哈尔医学院学报，2015，36（2）:190-191.
[7] 陈 飞，吴美琴，刘建文，等. 神经节苷脂与神经系统发育关系的研究进展[J]. 教育生物学杂志，2018,6（2）：101-106. 
[8] Posse-De Chaves E, Sipione S. Sphingolipids and gangliosides of the nervous in membrane function and dysfunction[J]. FEBS Lett, 2010,584(9):1748-1759.
[9] Rubovitch V, Zilberstein Y, Chapman J, et al. Restoring GMI ganglioside espression ameliorates axonal outgrowth inhibition and cognitive impairments induced by biast traumatic brain injury[J]. Sci Rep, 2017，7:41269.
[10] 李 兵，胡世颉，王 冰，等. 单唾液酸四已糖神经节苷脂钠治疗脑外伤癫痫250例疗效观察[J]. 陕西医学杂志，2016,45（2）：228-229,242.

备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(2014JM4162)
更新日期/Last Update: 2019-04-10