[1]马江卫,贾爱华,刘新艳,等.唑来膦酸联合经皮椎体后凸成形术治疗骨质疏松椎体压缩性骨折临床疗效观察*[J].陕西医学杂志,2019,(3):358-361.
　MA Jiangwei,JAI Aihua,LIU Xinyan,et al.Zoledronic acid combined with percutaneous balloon kyphoplasty forthe treatment of osteoporotic vertebral compression fractures[J].,2019,(3):358-361.
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唑来膦酸联合经皮椎体后凸成形术治疗骨质疏松椎体压缩性骨折临床疗效观察*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年3期
页码:
358-361
栏目:
基础研究
出版日期:
2019-03-05

文章信息/Info

Title:
Zoledronic acid combined with percutaneous balloon kyphoplasty forthe treatment of osteoporotic vertebral compression fractures
文章编号:
DOI:10.3969/j.issn.10007377.2019.03.020
作者:
马江卫1 ; 贾爱华2 ; 刘新艳2 ; 井长信2 ; 王 荣
1.陕西省榆林市第一医院骨科（榆林 719000）；2.陕西省榆林市第一医院内分泌科（榆林719000）
Author(s):
MA Jiangwei; JAI Aihua; LIU Xinyan; et al.
Department of Orthopedics, the First Hospital of Yulin City (Yulin719000)
关键词:
唑来膦酸; 经皮椎体后凸成形术; 骨质疏松性椎体压缩性骨折; 疼痛视觉模拟评分; 椎体高度; 骨密度
Keywords:
Key words Zoledronic acid; Percutaneous balloon kyphoplasty; Osteoporotic vertebral compression fractures; Visual analogue scale ; Vertebra height; Bone mineral density
分类号:
R683.2
文献标志码:
A
摘要:
摘 要 目的：观察唑来膦酸联合经皮椎体后凸成形术（PKP）治疗骨质疏松椎体压缩性骨折（OVCF）的临床疗效。方法：收集接受PKP治疗的OVCF患者60例，依据患者术后接受唑来膦酸与否，分为联合治疗组（A组，接受唑来膦酸治疗）及对照组（B组，未接受唑来膦酸治疗）。通过观察术前、术后患者疼痛视觉模拟评分（VAS）、椎体高度、骨密度的改变以及PKP术后再骨折的发生率，从而评估唑来膦酸联合PKP治疗OVCF的疗效。结果：A组与B组在术后1月、术后1年及术后2年,其VAS、椎体高度均较术前明显改善。术后2年A组VAS及椎体高度改善明显优于B组。术后1年及术后2年A组骨密度改善明显优于B组，且PKP术后再骨折发生率低于B组。结论：唑来膦酸联合PKP治疗OVCF临床疗效显著，可明显改善患者的临床症状，增加患者骨密度，降低PKP术后再骨折风险，改善患者远期预后。
Abstract:
Abstract Objective:To observe the efficacy of zoledronic acid combined with percutaneous balloon kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fractures(OVCF) . Methods:60 patients with OVCF and received PKP treatment were retrospectively analyzed and divided into two groups。Patients who received the application of Zoledronic Acid after PKP were divided into combination therapy group(group A, n=28),and who just received the PKP treatment were divided into control group(group B , n=32). Through the observation of visual analogue scale(VAS), vertebra height，bone mineral density（BMD）and refracture in preoperative and postoperative, to evaluate the efficacy of zoledronic acid combined with PKP in the treatment of OVCF. Results：After PKP treatment 1 month ,1 year and 2 years, the VAS and vertebra height were significantly improved in two groups. Two years after PKP, the VAS and vertebral height in group A were significantly improved than those in group B.After PKP treatment 1 year and 2 years, the improvement of BMD in group A was significantly better than that in group B, and the incidence of refracture in group A was significantly lower than that in group B. Conclusion :The clinical efficacy of zoledronic acid combined with PKP in the treatment of OVCF is significant, which can significantly relieve the clinical symptoms , increase the BMD, reduce the risk of refracture after PKP treatment, and improve the longterm prognosis.

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备注/Memo

备注/Memo:
*陕西省重点研发计划一般项目(2018SF013)
更新日期/Last Update: 2019-03-15