[1]冯苗苗,曹秋雨.miR335在子宫内膜癌患者血清中的表达及检测临床意义[J].陕西医学杂志,2019,(2):252-255.
　FENG Miaomiao,CAO Qiuyu..The expression and significance of miR335 in serum of patients with endometrial carcinoma[J].,2019,(2):252-255.
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miR335在子宫内膜癌患者血清中的表达及检测临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年2期
页码:
252-255
栏目:
临床病理
出版日期:
2020-02-05

文章信息/Info

Title:
The expression and significance of miR335 in serum of patients with endometrial carcinoma
文章编号:
DOI: 10.3969/j.issn.10007377.2019.02.031
作者:
冯苗苗; 曹秋雨
广州中医药大学第一附属医院妇科（广州 510405）
Author(s):
FENG Miaomiao;  CAO Qiuyu.
Department of Gynecology,  First Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangzhou 510405)
关键词:
子宫内膜癌; 血清; miR335; 病理特征; 标志物; 诊断
Keywords:
Key words Endometrial carcinoma; Serum; miR335; Pathological characteristics; Symbols; Diagnosis
分类号:
R737.33
文献标志码:
A
摘要:
摘 要 目的：探讨miR335在子宫内膜癌患者血清中的表达及其临床意义。方法：78例子宫内膜癌患者和70例健康妇女作为研究对象，应用RTPCR法检测血清miR335表达，比较两组患者血清miR335表达差异并分析miR335表达与子宫内膜癌临床病理特征相关性。结果：子宫内膜癌组患者血清miR335的相对表达量 （0.96±0.25）明显低于正常对照组（1.92±0.57），两组相比差异具有统计学意义（P<0.05）。子宫内膜癌患者血清miR335相对表达量与TNM分期、组织病理类型和淋巴结转移密切相关（P<0.05），而与患者的年龄、是否绝经、组织病理分级及CA125值无明显相关性（P＞0.05）；由ROC曲线分析可知，其曲线下面积为0.793（95%CI：0.526～0.975），诊断敏感性为89.43%，特异性为76.52%。结论：miR335在子宫内膜癌患者血清中呈低表达，且其表达水平与子宫内膜癌的发生发展密切相关，miR335可能成为诊断子宫内膜癌的潜在标志物和治疗新靶点。
Abstract:
Abstract Objective：To investigate the expression of miR335 in serum of patients with endometrial carcinoma and its clinical significance. Methods：78 endometrial cancer patients and 70 healthy women admitted were selected as study subjects. The serum miR335 expression was detected by RTPCR. The difference in serum miR335 expression between the two groups was compared. The correlation between miR335 expression and clinicopathological features of endometrial carcinoma was analyzed. Results:The relative expression level of serum miR335 in the endometrial cancer group (0.96±0.25) was significantly lower than that in the normal control group(1.92±0.57). The difference between the two groups was statistically significant (P<0.05). The relative expression of serum miR335 in patients with endometrial cancer was closely related to TNM staging, histopathological types and lymph node metastasis (P<0.05). However, there was no significant correlation between serum miR335 expression and age, menopause, histopathological grade and CA125 values (P>0.05).From the ROC curve analysis, the area under the curve was 0.793 (95% CI: 0.526～0.975), the diagnostic sensitivity was 89.43%, and the specificity was 76.52%.Conclusion：The expression of miR335 is low in the serum of patients with endometrial carcinoma. The expression level of miR335 is closely related to the occurrence and development of endometrial carcinoma. miR335 may be a potential marker and a new therapeutic target in the diagnosis of endometrial carcinoma. 

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更新日期/Last Update: 2019-03-13