[1]李武军,赵 海△,王明亮,等.高高原地区腹腔镜胆囊切除术对患者肝功能及炎症因子的影响*[J].陕西医学杂志,2019,(2):173-175.
　LI Wujun,ZHAO Hai,WANG Mingliang,et al.Study the effects of liver function and inflammatory factors in patients with  laparoscopic cholecystectomy in high altitude area[J].,2019,(2):173-175.
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高高原地区腹腔镜胆囊切除术对患者肝功能及炎症因子的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年2期
页码:
173-175
栏目:
临床研究
出版日期:
2020-02-05

文章信息/Info

Title:
Study the effects of liver function and inflammatory factors in patients with  laparoscopic cholecystectomy in high altitude area
文章编号:
DOI: 10.3969/j.issn.10007377.2019.02.009
作者:
李武军1; 2; 赵 海2; 3△; 王明亮2; 贡桑明久2
1.西安医学院第一附属医院(西安医学院全科医学院)（西安710077）； 2.西藏自治区阿里地区人民医院（阿里859000）；3.陕西省人民医院(西安医学院附属医院)（西安 710068）
Author(s):
LI Wujun;  ZHAO Hai; WANG Mingliang; et al.
The First Affiliated Hospital of Xi’an Medical College, General Surgery School of Xi’an Medical College (Xi’an 710077)
关键词:
腹腔镜胆囊切除术; 开腹胆囊切除术; 肝功能; 炎症因子; 高高原地区; 对比研究
Keywords:
Key words Laparoscopic cholecystectomy; Conventional open cholecystectomy; Liver function; Inflammatory factors; High plateau region; Comparativestudy
分类号:
R657.4
文献标志码:
A
摘要:
摘 要 〖JP3〗目的：研究海拔4500 m的高高原地区低氧条件下，腹腔镜胆囊切除术（LC）与传统开腹胆囊切除术（OC）对患者术后肝功能及炎症因子的影响。方法：将西藏阿里地区人民医院收治的88例胆囊结石患，随机分为LC组(42例)和OC组（46例），分别分析两组患者术后第1天和第5天肝功能（ALT、AST、ALP、TBIL）及炎症因子（CRP、IL6、IL8）指标的变化。结果：两组患者术后第1天的ALT、AST、TBIL均比本组术前升高，而ALP低于术前，差异有统计学意义(P＜0.05)，至术后第5天均恢复至术前水平(P＞0.05）；术后第1天、第5天两组间的肝功能指标差异无统计学意义(P＞0.05）。两组患者术后第1天的炎症因子水平均较本组术前升高，差异有统计学意义(P＜0.05)；至术后第5天LC组炎症因子仍高于本组术前(P＜0.05)，OC组炎症因子已恢复至本组术前水平(P＞0.05），LC组与OC组间，术后第1天及第5天的炎症因子比较，差异有统计学意义(P＜0.05)。结论：LC与OC都会使患者肝功能下降，并使炎症因子水平升高，但对炎症因子的影响LC比OC影响更大。但LC的应用较为广泛，其对腹壁的创伤小，利于恢复，高高原地区亦可以推广相应手术。
Abstract:
Abstract Objective: To study the effects of liver function and inflammatory factors by laparoscopic cholecystectomy (LC) and conventional open cholecystectomy (OC) on high altitude area, respectively. Methods: Eightyeight patients with gallstones were collected into this study.88 cases with gallstones were random divided into two groups, LC group（42 cases）and OC group（46cases）. To study the effects of liver function index (ALT, AST, ALP, TBIL) and inflammatory factors (CRP, IL6, IL8) at 1st day and 5th days after operation in two groups, respectively. Results: Liver function index (ALT, AST and TBIL) levels of two groups were show significantly higher at the 1st postoperative day than those in the preoperative. But ALP was show lower than before surgery (P<0.05). Liver function index levels were recovered to preoperative levels at 5th days after operation (P>0.05). Liver function index were show no significant difference between the two groups at 1st day and 5th days after operation (P>0.05). For the levels of Inflammatory factors (CRP, IL6 and IL8) were significantly higher than those before surgery in two groups, respectively (P<0.05). The levels inflammatory factors in the LC group were still higher than those in the preoperative at 5th days after operation (P<0.05). But the levels of inflammatory factors in the OC group were recovered to preoperative levels at 5th days after operation (P>0.05). The levels of Inflammatory factors were show significant difference between the two groups at 1st day and 5th days after operation (P<0.05). Conclusions: Both LC and OC decrease liver function and increase the level of inflammatory cytokines, but the effect of LC on inflammatory factors is greater than that of OC. LC surgery has little trauma to the abdominal wall compared with OC surgery.LC operation can be promoted in high altitude areas.

参考文献/References:

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备注/Memo

备注/Memo:
*西藏自治区自然科学基金资助项目（XZ2017ZRZYZ38）
更新日期/Last Update: 2019-03-13