[1]全细云 ,李明△,陈栋良,等.胃癌组织中microRNA214和MGAT5表达及预后的相关性分析*[J].陕西医学杂志,2019,(1):117-120.
　QUAN Xiyun,LI Ming,CHEN Dongliang..Correlation between microRNA214 and MGAT5 expression and prognosis in gastric cancer[J].,2019,(1):117-120.
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胃癌组织中microRNA214和MGAT5表达及预后的相关性分析*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
117-120
栏目:
临床病理
出版日期:
2019-01-05

文章信息/Info

Title:
Correlation between microRNA214 and MGAT5 expression and prognosis in gastric cancer
文章编号:
DOI:10.3969/j.issn.10007377.2019.01.037
作者:
全细云1  ;  李明2△ ;  陈栋良1; 邓燚1; 彭曼1
1. 湖南省株洲市中心医院病理科（株洲412000）；2.湖南省株洲市中心医院急诊科（株洲 412000）
Author(s):
QUAN Xiyun; LI Ming; CHEN Dongliang.
Department of Pathology，Zhuzhou Central Hospital in Hunan Province（Zhuzhou 412000）
关键词:
胃癌组织; microRNA214; MGAT5; 表达; 预后; 相关性分析
Keywords:
Key words Gastric cancer tissue;  MicroRNA214;  MGAT5;  Expression; Prognosis; Correlation analysis
分类号:
R735.2
文献标志码:
A
摘要:
摘 要 目的：探讨胃癌组织中microRNA214和MGAT5的表达及预后的相关性分析。 方法：随机选取80例胃癌患者，收集其进行手术切除的胃组织标本作为研究对象，患者的胃癌组织作为研究组，患者的癌旁正常胃黏膜组织作为对照组，使用免疫组织化学的方法对患者的胃癌组织及癌旁正常胃粘膜组织进行检测，对测得的结果进行分析。 结果：患者胃癌组织中的microRNA214和MGAT5的表达率明显高于癌旁正常胃黏膜组织(P＜0.05)；在胃癌中出现淋巴结转移患者的microRNA214和MGAT5的表达率明显高于未出现淋巴结转移的患者(P＜0.05)，Ⅲ、Ⅳ期的microRNA214和MGAT5表达率明显高于Ⅰ期、Ⅱ期患者(P＜0.05)；男性胃癌患者的microRNA214和MGAT5表达率明显低于女性患者(P＜0.05)；在年龄方面，＜60岁的胃癌患者要比>60岁患者的microRNA214和MGAT5表达率要明显低(P＜0.05)，肿块＜5 cm的胃癌患者的microRNA214和MGAT5表达率要比肿块>5 cm的胃癌患者要明显偏低(P＜0.05)，分化程度呈高、中分化的胃癌患者的microRNA214和MGAT5表达率要比分化程度呈低分化的要明显偏低(P＜0.05)。 结论：microRNA214和MGAT5在胃癌组织中高表达，能够预测胃癌的发展、发生以及预后，在临床诊断和治疗过程中会起到一定的预示作用。
Abstract:
AbstractObjective：To investigate the correlation between the expression of microRNA214 and MGAT5 and prognosis in gastric cancer. Methods：80 cases of gastric cancer were randomly selected to collect the resected gastric tissue samples as the research object. The gastric carcinoma tissue of the patient was used as the study group and the normal gastric mucosa tissue beside the cancer was used as the control group. The gastric carcinoma tissue was used in the patients with immunohistochemical method. The normal gastric mucosa tissues were detected and the results were analyzed. Results：the expression rate of microRNA214 and MGAT5 in gastric cancer tissues was significantly higher than that of normal gastric mucosa adjacent to the carcinoma (P＜0.05). The expression rate of microRNA214 and MGAT5 in patients with lymph node metastasis in gastric cancer was significantly higher than that in patients without lymph node metastasis (P＜0.05). The expression rate of microRNA214 and MGAT5 in stage III and IV was obvious. Higher than phase I and stage II patients (P＜0.05); the expression rate of microRNA214 and MGAT5 in men with gastric cancer was significantly lower than that of women (P＜0.05); in age,the expression rate of microRNA214 and MGAT5 in patients with ＜60 years old was significantly lower than that of >60 years old (P＜0.05),and microRNA214 and MGAT5 expression rates of patients with gastric cancer in swollen block ＜5cm were to be expressed. The gastric cancer patients with mass >5cm were significantly lower (P＜0.05),and the expression rate of microRNA214 and MGAT5 in patients with high differentiation and differentiation was significantly lower than that of low differentiation (P＜0.05). Conclusion：the high expression of microRNA214 and MGAT5 in gastric carcinoma can predict the development,occurrence and prognosis of gastric cancer,and it will play a certain prognostic role in the process of clinical diagnosis and treatment.

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备注/Memo

备注/Memo:
*国家自然科学基金青年科学基金资助项目（81402497）
更新日期/Last Update: 2019-01-22