[1]刘菲,高治华△.多巴酚丁胺与酚妥拉明联合小剂量多巴胺治疗小儿重症肺炎临床研究*[J].陕西医学杂志,2019,(1):89-91，95.
　LIU Fei,GAO Zhihua..Comparison of efficacy of dobutamine and phenolamine combined with small dose of dopamine in the treatment of severe pneumonia in children[J].,2019,(1):89-91，95.
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多巴酚丁胺与酚妥拉明联合小剂量多巴胺治疗小儿重症肺炎临床研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
89-91，95
栏目:
药物与临床
出版日期:
2019-01-05

文章信息/Info

Title:
Comparison of efficacy of dobutamine and phenolamine combined with small dose of dopamine in the treatment of severe pneumonia in children
文章编号:
DOI:10.3969/j.issn.10007377.2019.01.028
作者:
刘菲; 高治华△
陕西省友谊医院儿科（西安 710068）
Author(s):
LIU Fei; GAO Zhihua.
Pediatric of Shaanxi Friendship Hospital(Xi’an 710068)
关键词:
小儿重症肺炎; 酚妥拉明; 多巴酚丁胺; 小剂量多巴胺; 临床症状; 疗效
Keywords:
Key words Pediatric severe pneumonia;  Phenolamine;  Dobutylamine;  Small dose of dopamine;  Clinical symptoms;  Curative effect
分类号:
R725.6
文献标志码:
A
摘要:
摘 要 目的：研究多巴酚丁胺与酚妥拉明联合小剂量多巴胺对小儿重症肺炎的临床疗效。方法： 选取就诊并确诊为重症肺炎的180例患儿为研究对象。根据随机数表法将研究对象分为90例对照组和90例观察组。对照组患儿采用多巴酚丁胺联合小剂量多巴胺治疗，观察组使用多巴酚丁胺与酚妥拉明联合小剂量多巴胺治疗。比较两组患儿的临床疗效、肺通气功能指标、血氧指标及服药期间的不良反应。结果： 经过6d的治疗，观察组患儿的总有效率达到93.34%，显著高于对照组的总有效率76.67%，差异有统计学意义（P＜0.01）；治疗后两组的肺通气指标、血氧饱和度（SPO2）、二氧化碳分压（PO2）较治疗前均显著升高，比较差异有统计学意义（P＜0.05），治疗后，观察组的肺通气指标（包含FEV1和FEV1/FVC）、PO2指标显著高于对照组，两组差异有统计学意义（P＜0.05）；观察组的气喘，咳嗽、肺啰音、发热临床症状以及住院时间均显著小于对照组，两组差异有统计学意义（P＜0.05）。结论：采用多巴酚丁胺与酚妥拉明联合小剂量多巴胺治疗小儿重症肺炎的临床疗效优于多巴酚丁胺联合小剂量多巴胺，有效地改善肺通气功能，提高血氧指标，减少不良反应的发生，在治疗小儿重症肺炎方面有良好的参考价值。
Abstract:
AbstractObjective： to study the clinical effect of dobutamine and phenolamine combined with small dose of dopamine on severe pneumonia in children.Methods： 180 children with severe pneumonia were selected.According to the random table method,the subjects were randomly divided into 90 control groups and 90 observation groups.The control group were treated with dobutamine combined with a small dose of dopamine,and the observation group was treated with dobutamine combined with phenolamine combined with a small dose of dopamine.To compare the clinical effect of two groups of children; Comparison of clinical efficacy,pulmonary ventilation function index,blood oxygen index and adverse reactions were compared between the two groups..Results ：After 6D treatment,the total effective rate of children in the observation group reached 93.34 %,which was significantly higher than the total effective rate of 76.67 % in the control group. The difference was statistically significant(P＜0.01）；The pulmonary ventilation index,SPO2,and PO2 in the two groups after treatment were significantly higher than before treatment,and were statistically significant(P＜0.05），After treatment,the pulmonary ventilation indexes(including FEV1 and FEV1/FVC) and PO2 were significantly higher in the observation group than in the control group. The difference between the two groups was statistically significant(P＜0.05）；In the observation group,asthma,cough,lung voice,fever clinical symptoms and hospitalization time were all significantly smaller than in the control group. The difference between the two groups was statistically significant(P＜0.05）.Conclusion： dobutamine and phenolamine combined with small dose of dopamine is better than dobutamine combined with small dose of dopamine in the treatment of children with severe pneumonia. It effectively improves lung ventilation function,improves blood oxygen index,and reduces the occurrence of adverse reactions. It has a good reference value in the treatment of severe pneumonia in children.〖LM〗

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相似文献/References:

[1]彭林强,薛 满,马春利,等.头孢噻肟钠联合酚妥拉明治疗重症肺炎疗效及对患儿肺功能、免疫功能、炎症因子水平的影响*[J].陕西医学杂志,2019,(11):1556.

备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(2010JM4051)
更新日期/Last Update: 2019-01-22