[1]王玺凯,刘 媛,房怡君,等.血清心脏型脂肪酸结合蛋白检测在急性中毒早期严重程度分级中的价值研究*[J].陕西医学杂志,2019,(12):1725-1728.
　WANG Xikai,LIU Yuan,FANG Yijun,et al.Value of serum HFABP as a marker of early severity classificationin patients with acute poisoning[J].,2019,(12):1725-1728.
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血清心脏型脂肪酸结合蛋白检测在急性中毒早期严重程度分级中的价值研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年12期
页码:
1725-1728
栏目:
临床检验
出版日期:
2019-12-05

文章信息/Info

Title:
Value of serum HFABP as a marker of early severity classificationin patients with acute poisoning
文章编号:
DOI:10.3969/j.issn.10007377.2019.12.041
作者:
王玺凯; 刘 媛; 房怡君; 王 琳; 马景晶; 杜永锋△
西安市中心医院职业病科（西安 710004）
Author(s):
WANG Xikai; LIU Yuan; FANG Yijun; et al
关键词:
心脏型脂肪酸结合蛋白; 分级标志物; 急性中毒; 受试者工作特征曲线
Keywords:
Key words Hearttype fatty acidbinding protein; Grading markers; Acute poisoning; Receiver operating characteristic
分类号:
R595
文献标志码:
A
摘要:
摘 要 目的:研究血清心脏型脂肪酸结合蛋白(HFABP)含量在急性中毒患者早期严重程度分级中的临床意义。方法:收集资料齐全的急性中毒患者178例，按中毒严重程度分为轻度组、中度组和重度组，并进行急性生理学及慢性健康状况评分(APACHEⅡ)；另选取同期健康体检者50例作为正常对照组。各组均检测血清HFABP含量，统计分析各组血清HFABP和APACHEⅡ评分，及其两者相关关系，并采用受试者工作特征曲线(ROC)评估HFABP在急性中毒严重程度分级中的价值。结果：重度组血清HFABP和APACHEⅡ评分明显高于正常组、轻度组和中度组（P＜005），血清HFABP与APACHEⅡ评分呈正相关(r=0515，P＜0001)，ROC曲线显示，血清HFABP评估急性中毒轻中重度的最佳临界值分别为219ng/ml、281ng/ml和1500ng/ml。结论：血清HFABP含量随急性中毒严重程度分级的提高而升高，可将其作为临床评估急性中毒患者早期严重程度分级的标志物。
Abstract:
Abstract Objective:To study the clinical significance of serum hearttype fatty acid binding protein (HFABP) in the early severity classification of acute poisoning patients Methods:178 patients with acute poisoning were analyzed They were divided into mild，moderate and severe groups according to the severity of poisoning Acute physiology and chronic health status (APACHE II) were scored Another 50 healthy people in the same period were selected as normal control groupSerum HFABP levels were measured in each group Serum HFABP and APACHEE II scores of each group were analyzed and their correlation was analyzed The value of HFABP in severity classification of acute poisoning was evaluated by ROC curve Results:Serum HFABP and APACHE II scores in severe group were significantly higher than those in normal group，mild group and moderate group (P＜005) Serum HFABP was positively correlated with APACHE II scores (r=0515，P＜0001)ROC curve analysis showed that the optimal critical values of serum HFABP for assessing the severity of acute poisoning were 219 ng/ml，281 ng/ml and 1500 ng/ml，respectively Conclusion:Serum HFABP content increased with the increase of severity grade of acute poisoning，which can be used as a marker for clinical evaluation of early severity grade of acute poisoning patients

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备注/Memo

备注/Memo:
*陕西省重点研发计划项目(2017SF253)
更新日期/Last Update: 2019-12-19