[1]张余黄,殷鹏飞.多烯磷脂酰胆碱联合还原型谷胱甘肽治疗酒精性肝炎效果观察*[J].陕西医学杂志,2019,(12):1715-1717,封3.
　ZHANG Yuhuang,YIN Pengfei..Curative effect of polyene phosphatidyl choline combined with glutathione on alcoholic hepatitis[J].,2019,(12):1715-1717,封3.
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多烯磷脂酰胆碱联合还原型谷胱甘肽治疗酒精性肝炎效果观察*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年12期
页码:
1715-1717,封3
栏目:
药物与临床
出版日期:
2019-12-05

文章信息/Info

Title:
Curative effect of polyene phosphatidyl choline combined with glutathione on alcoholic hepatitis
文章编号:
DOI:10.3969/j.issn.10007377.2019.12.038
作者:
张余黄; 殷鹏飞
陕西省安康市中心医院消化科（安康 725000）
Author(s):
ZHANG Yuhuang; YIN Pengfei.
Department of Gastroenterology,Ankang Central Hospital (Ankang 725000)
关键词:
多烯磷脂酰胆碱; 还原型谷胱甘肽; 酒精性肝炎; 肝功能; 透明质酸
Keywords:
Key words Polyene phosphatidyl choline; Glutathione; Alcoholic hepatitis; Liver function; Hyaluronic acid
分类号:
R5751
文献标志码:
A
摘要:
摘 要 目的：观察多烯磷脂酰胆碱（PPC）联合还原型谷胱甘肽（GSH）对酒精性肝炎（AH）的治疗效果。方法：选取AH患者158例，以随机数字表法将其分为对照组与联合组各79例。对照组予GSH治疗，联合组在对照组的治疗基础上，加予PPC进行治疗，两组患者均连续治疗4周。于治疗前、后检测所有患者血清中谷丙转氨酶（ALT）、天冬氨酸转氨酶（AST）、γ谷氨酰转肽酶（GGT）、总胆红素（TBIL），以放射免疫法检测透明质酸（HA）和III型前胶原（PCIII）指标；并于治疗后统计两组患者的总有效率，以全数字彩色超声诊断仪检查患者肝区情况；同时观察治疗期间两组患者出现不良反应发生情况。结果：联合组患者治疗后总有效率为9114%，明显高于对照组7975%（χ2=4122，P=0042）。两组患者治疗后ALT、AST、GGT、TBIL、HA、PCIII各指标均较治疗前明显下降（P＜005）；与对照组治疗后相比，联合组患者治疗后ALT（t=8775，P＜0001）、AST（t=12071，P＜0001）、GGT（t=6695，P＜0001）、TBIL（t=9369，P＜0001）、HA（t=11349，P＜0001）、PCIII（t=10612，P＜0001）水平更低。B超结果显示，联合组治疗后管道结构显示不清、肝肿大情况发生率显著低于对照组（χ2=6482，P=0011；χ2=6661，P=0010）。结论：采用PPC联合GSH治疗AH优于单用GSH，有助于患者肝功能的恢复。
Abstract:
Abstract Objective：To observe curative effect of polyene phosphatidyl choline (PPC) combined with glutathione (GSH) on alcoholic hepatitis (AH)Methods：158 AH patients were enrolledThey were divided into control group and combination group by random number table method,79 cases in each groupThe control group was treated with GSHThe combination group was treated with PPC on the basis of control groupBoth groups were continuously treated for 4 weeksBefore and after treatment,alanine aminotransferase (ALT),aspartate aminotransferase (AST),γglutamyltranspeptidase (GGT) and total bilirubin (TBIL) in serum of all patients were detected by automatic biochemical analyzerThe radioimmunoassay was performed to detect hyaluronic acid (HA) and type III procollagen (PCIII)After treatment,total response rates of the two groups were statistically analyzedThe conditions in liver area were examined by complete digital color ultrasound diagnostic apparatusThe occurrence of adverse reactions in the two groups during treatment was observedResults：After treatment,total response rate in combination group was significantly higher than that in control group (9114% vs 7975%) (χ2=4122,P=0042)After treatment,ALT,AST,GGT,TBIL,HA,and PCIII of both groups were significantly decreased (P＜005)Compared with those in control group after treatment,levels of ALT (t=8775,P＜0001),AST (t=12071,P＜0001),GGT (t=6695,P＜0001),TBIL (t=9369,P＜0001),HA(t=11349,P＜0001) and PCIII (t=10620,P＜0001) were lower in combination groupThe results of Bultrasound showed that incidence of tube structure unclear and hepatomegaly in combination group was significantly lower than that in control group (χ2=6482,P=0011χ2=6661,P=0010)Conclusion:PPC combined with GSH is superior to GSH alone in treatment of AH,which is helpful for recovery of liver function

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备注/Memo

备注/Memo:
*陕西省卫生健康委员会科研项目(2017052KJH8352)
更新日期/Last Update: 2019-12-19