[1]孙 青,吕丹雨,秦雪梅,等.喉鳞癌中DNA结合/分化抑制蛋白2和血管内皮生长因子C表达及临床意义[J].陕西医学杂志,2019,(1):74-76.
　SUN Qing,LV Danyu,QIN Xuemei,et al.Expression and significance of ID2 and VEGFC in laryngeal squamous cell carcinoma[J].,2019,(1):74-76.
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喉鳞癌中DNA结合/分化抑制蛋白2和血管内皮生长因子C表达及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
74-76
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Expression and significance of ID2 and VEGFC in laryngeal squamous cell carcinoma
文章编号:
DOI:10.3969/j.issn.10007377.2019.01.023
作者:
孙 青; 吕丹雨; 秦雪梅;  陈国辉;  白广平△
复旦大学附属中山医院青浦分院耳鼻咽喉科（上海 201700）
Author(s):
SUN Qing ;  LV Danyu ;  QIN Xuemei ;  et al.
Department of Otorhinolaryngology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University (Shanghai 201700)
关键词:
喉鳞癌; DNA结合/分化抑制蛋白2; 血管内皮生长因子C; 免疫学; 临床意义; 相关性
Keywords:
Key words laryngeal squamous cell carcinoma; ID1; VEGFC; immunology; clinical significance; correlation
分类号:
R739.65
文献标志码:
A
摘要:
摘 要 目的:检测喉鳞癌中DNA结合/分化抑制蛋白2（ID2）和血管内皮生长因子C（VEGFC）的表达特征，分析其临床意义及相关性。方法:以67例喉鳞癌的患者作为观察组，留取临床资料及术后石蜡标本，以45例声带息肉组织作为对照组，应用免疫组化SP法检测二组中ID2和VEGFC的表达。结果:二组中ID2和VEGFC的表达差别有统计学意义（P＞0.05），观察组中ID2和VEGFC的表达与病变的增殖指数、脉管累犯和淋巴结转移密切相关，ID2的表达与肿瘤的分化程度和病变最大径密切相关。观察组中ID2和VEGFC的表达具有正相关性。结论:ID2和VEGFC在喉鳞癌中高表达，对肿瘤的形成和发展有一定的促进作用。ID2与VEGFC有一定的协同作用。
Abstract:
Abstract Objective:To detect the expressions of DNA binding/differentiation inhibitor protein2(ID2) and vascular endothelial growth factorC (VEGFC) in laryngeal squamous cell carcinoma, analyze their clinical significance and correlation. Methods: Expression of ID2 and VEGFC were detected in 67 laryngeal squamous cell carcinoma (observation group) and 45 vocal cord polyp(control group) by IHC. Results :Expression of ID2 and VEGFC was significantly different in two groups. Expressions of ID2 and VEGFC were closely related to the proliferation index, vascular involvement and lymph node metastasis. Expression of ID2 was closely related to differentiation and max diameter. There was positive correlation between ID2 and VEGFC in the observation group. Conclusion: Higher expressions of ID2 and VEGFC can promote the formation and development in laryngeal squamous cell carcinoma. ID2 and VEGFC has a synergistic effect.

参考文献/References:

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更新日期/Last Update: 2019-01-22