[1]王晓东,景鹏宇△,崔 凯,等.术前外周血中性粒细胞淋巴细胞比值对ⅠⅢ期非小细胞肺癌患者预后的影响[J].陕西医学杂志,2019,(12):1612-1615.
点击复制

术前外周血中性粒细胞淋巴细胞比值对ⅠⅢ期非小细胞肺癌患者预后的影响
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年12期
页码:
1612-1615
栏目:
临床研究
出版日期:
2019-12-05

文章信息/Info

文章编号:
DOI:10.3969/j.issn.10007377.2019.12.009
作者:
王晓东; 景鹏宇△; 崔 凯; 梁晓华
空军军医大学唐都医院胸外科六病区（西安 710038）
关键词:
外周血中性粒细胞; 淋巴细胞; 预后因素; 非小细胞肺癌; 手术治疗; 总生存时间
分类号:
R7342
文献标志码:
A
摘要:
摘 要 目的：探讨术前外周血中性粒细胞计数与淋巴细胞计数比值（NLR）对非小细胞肺癌（NSCLC）患者预后的影响。方法：收集行根治性手术切除的ⅠⅢ期非小细胞肺癌患者136例。应用ROC曲线分析确定对患者生存结局有预测意义的最佳NLR值，以此值为界限划分为NLR高组及NLR低组，应用COX比例风险回归模型进一步行多因素分析以验证NLR是否为ⅠⅢ期非小细胞肺癌患者的独立预后因素；如果为其独立预后因素，应用KaplanMeier计算总生存时间（OS）及无疾病生存时间（DFS），应用Logrank法对比NLR高组与NLR低组两组患者的生存差异是否有统计学意义。结果：NLR对患者死亡的预测有意义的最佳值为298，AUC=0721，95%CI：0627～0815，P=0000。将136例分为NLR≤298和NLR＞298两组。术前NLR为ⅠⅢ期非小细胞肺癌患者的独立风险因素，RR 1315，95%CI（1083～1659），P=0044。低NLR组中位OS 52个月，95%CI（410～629），高NLR组中位OS 41个月，95%CI（3004～5196），P=0021；低NLR组中位DFS 26个月，95%CI（1336～3864），高NLR组中位DFS 15个月，95%CI（785～2215），P=0009。结论：术前NLR可能是ⅠⅢ期可手术患者的独立不良预后因素；术前高NLR可能预示较短的总生存时间及较早复发。

参考文献/References:

[1] Siegel R,Naishadham D,Jemal ACancer statistics,2013[J] .Ca Cancer J Clin,2013,63(1):1130
[2] Herbst RS,Heymach JV,Lippman SM,et al.Lung cancer[J] .N Engl J Med,2008,359(13):13671380
[3] Crumley AB,Memillan DC,Mckernan M,et al.Evaluation of an inflammationbased prognostic score in patients with inoperable gastrooesophageal cancer[J] .Br J Cancer,2006,94(5):637641
[4] Tomita M,Ayabe T,Nakamura KThe advanced lung cancer inflammation index is an independent prognostic factor after surgical resection in patients with nonsmallcell lung cancer[J] .Interact Cardiovasc Thorac Surg,2018,26(2):288292
[5] Asaoka T,Miyamoto A,Maeda S,et al.Prognostic impact of preoperative NLR and CA199 in pancreatic cancer[J] .Pancreatology,2016,16(3):434440
[6] Mizunuma M,Yokoyama Y,Futagami M，et al.The pretreatment neutrophiltolymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer[J] .Int J Clin Oncol,2015,20(5):989996
[7] Mac Donald NCancer cachexia and targeting chronic inflammation:a unified approach to cancer treatment and palliative/supportive care[J] .J Support Oncol,2007,5(4):157162,164166,183
[8] Bremnes RM,AIShibli K,Donnem T,et al.The role of tumorinfiltrating immune cells and chronic inflammation at the tumor site on cancer development,progression,and prognosis:emphasis on nonsmall cell lung cancer[J] .J Thorac Oncol,2011,6(4):824833
[9] Remedi MM,Donadio AC,Chiabrando GA.Polymorphonuclear cells stimulate the migration and metastatic potential of rat sarcoma cells[J] .Int J Exp Pathol,2009,90(1):4451
[10] Bassani B,Baci D,Gallazzi M,et al.Natural killer cells as key players of tumor progression and angiogenesis:old and novel tools to divert their protumor activities into potent antitumor effects[J] .Cancers (Basel),2019,461(11):129
[11] Menetrier caux C,Ray coquard I,Blay JY,et al.Lymphopenia in cancer patients and its effects on response to immunotherapy:an opportunity for combination with cytokines?[J] .J Immunother Cancer,2019,7(1):85
[12] Kaneko M,Nozawa H,Sasaki K,et al.Elevated neutrophil to lymphocyte ratio predicts poor prognosis in advanced colorectal cancer patients receiving oxaliplatinbased chemotherapy[J] .Oncology,2012,82(5):261268
[13] Mc Millan DCThe systemic inflammationbased glasgow prognostic score:a decade of experience in patients with cancer[J] .Cancer Treat Rev,2013,39(5):534540
[14] Cedres S,Torrejon D,Martinez A,et al.Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV nonsmall cell lung cancer[J] .Clin Transl Oncol,2012,14(11):864869
[15] Zhang H,Xia H,Zhang L,et al.Clinical significance of preoperative neutrophillymphocyte vs plateletlymphocyte ratio in primary operable patients with nonsmall cell lung cancer[J] .Am J Surg,2015,210(3):526535

更新日期/Last Update: 2019-12-19