[1]林文利.连续性肾脏替代治疗对脓毒血症合并急性肾损伤患者脏器功能及存活率影响研究[J].陕西医学杂志,2019,(1):22-24.
　LIN Wenli..Effect of continuous renal replacement therapy on organ function and survival rate in patients with sepsis and AKI[J].,2019,(1):22-24.
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连续性肾脏替代治疗对脓毒血症合并急性肾损伤患者脏器功能及存活率影响研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
22-24
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Effect of continuous renal replacement therapy on organ function and survival rate in patients with sepsis and AKI
文章编号:
DOI:10.3969/j.issn.10007377.2019.01.007
作者:
林文利
陕西省商洛市中心医院中心ICU（商洛 726000）
Author(s):
LIN Wenli.
Shangluo Central Hospital Central ICU in shaanxi province (Shangluo 726000)
关键词:
脓毒血症 急性肾损伤 连续性肾脏替代治疗 脏器功能 存活率
Keywords:
Key words Sepsis; Acute kidney injury; Continuous renal replacement therapy; Organ function; Survival rate
分类号:
R692
文献标志码:
A
摘要:
摘 要 目的：探讨连续性肾脏替代疗法（CRRT）对脓毒血症合并急性肾损伤（AKI）患者脏器功能及存活率影响。方法：将56例脓毒血症合并AKI患者均分为两组。对照组选择常规血液灌注疗法实施治疗；观察组在此基础上实施CRRT治疗。对比两组治疗前及观察治疗72h后肾脏功能、凝血功能、心脏灌注功能及感染相关器官功能衰竭（SOFA）评分变化情况。结果：观察治疗72h后，两组Scr、BUN、Lac含量及SOFA评分均明显降低， ALB含量增加（P＜0.05）；MAP、CVP 、ScvO2 、PaO2/F iO2明显升高，PT明显延长（P＜0.05）；且观察组Scr、BUN、Lac含量及SOFA评分明显低于对照组，ScvO2 、PaO2/F iO2明显高于对照组，PT延长时间明显较对照组短（P＜0.05）；两组血流动力指标间差异无统计学意义（P＞0.05）。随访期间观察组12、24个月内存活率分别为96.43%、89.29%，明显高于对照组（P＜0.05）。结论：CRRT可有效改善脓毒血症合AKI患者肾功能及氧合状态，提高心脏灌注水平，器官功能改善明显，且对凝血功能影响小，存活率高。
Abstract:
Abstract Objective：To investigate the effect of continuous renal replacement therapy (CRRT) on organ function and survival rate in patients with sepsis and acute kidney injury (AKI). Methods：56 patients with sepsis and AKI who met the inclusion criteria were randomly divided into two groups. The control group was treated with conventional blood perfusion therapy; The observation group was treated with CRRT on the basis of the control group. The changes of renal function,coagulation function,cardiac perfusion function and infectionrelated organ failure (SOFA) scores were compared before and after 72 hours of treatment.Results：After 72 hours of observation and treatment,the contents of Scr,BUN,Lac and SOFA were significantly decreased,and the content of ALB was increased (P＜0.05)，MAP,CVP,ScvO2,PaO2/F iO2 were significantly increased,and PT was significantly prolonged (P＜0.05).The Scr,BUN,Lac content and SOFA score of the observation group were significantly lower than those of the control group,ScvO2 and PaO2/FiO2 were significantly higher than the control group,and the prolongation time of PT was significantly shorter than that of the control group (P＜0.05).There was no significant difference in blood flow index between the two groups (P>0.05).During the followup period,the survival rate of the observation group was 96.43% and 89.29%,respectively,which was significantly higher than that of the control group (P＜0.05).Conclusion：CRRT can effectively improve renal function and oxygenation status in patients with sepsis and AKI,improve cardiac perfusion level,improve organ function,and have little effect on coagulation function and high survival rate.

参考文献/References:

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更新日期/Last Update: 2019-01-22