[1]陈风慧,王晓华,范春梅△.补充外源性维生素D对老年溃疡性结肠炎患者氧化-抗氧化失衡、 肠道黏膜屏障和临床预后的影响*[J].陕西医学杂志,2018,(12):1634-1637.
　Chen Fenghui,Wang Xiaohua,Fan Chunmei..Effects of exogenous vitamin D treatment on oxidation-antioxidant imbalance, intestinal mucosal barrier and clinical prognosis in elderly patients with ulcerative colitis〖WT4”BZ〗[J].,2018,(12):1634-1637.
点击复制

补充外源性维生素D对老年溃疡性结肠炎患者氧化-抗氧化失衡、 肠道黏膜屏障和临床预后的影响*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2018年12期
页码:
1634-1637
栏目:
药物与临床
出版日期:
2018-12-31

文章信息/Info

Title:
Effects of exogenous vitamin D treatment on oxidation-antioxidant imbalance, intestinal mucosal barrier and clinical prognosis in elderly patients with ulcerative colitis〖WT4”BZ〗
文章编号:
DOI:10.3969/j.issn.1000-7377.2018.12.034
作者:
陈风慧1; 王晓华2; 范春梅3△
1.西电集团医院急诊科（西安710077）,2.陕西学前师范学院卫生所 ( 西安710061)， 3.陕西省延安市人民医院消化内科（延安716000）
Author(s):
Chen Fenghui;  Wang Xiaohua;  Fan Chunmei.
Department of Emergency，Xi’an XD Group Hospital(Xi’an 710077)
关键词:
结肠炎; 溃疡性/治疗 维生素D/治疗应用 氧化性应激 ＠肠道黏膜屏障 预后
Keywords:
Key words Colitis; ulcerative/therapy Vitamin D/therupeutic uses Oxidative stress Prognosis〖LM〗 Intestinal mucosal barrier
分类号:
R574.6
文献标志码:
A
摘要:
摘 要 目的：观察补充外源性维生素D对老年溃疡性结肠炎(UC)患者氧化-抗氧化失衡、肠道黏膜屏障和临床预后的影响。方法：将82例老年UC患者随机分为观察组(n=40例)和对照组(n=42例)，对照组给予美沙拉秦肠溶片治疗，观察组在对照组基础上补充外源性维生素D制剂治疗，疗程均为3个月。记录两组的临床疗效，并观察两组治疗前后改良Mayo评分、氧化应激和肠黏膜屏障指标的变化；记录两组生活质量、复发率。结果：观察组临床疗效显著高于对照组(P＜0.05)；两组治疗后改良Mayo评分系统单项(排便次数、便血、内镜发现、总体评价)和总分值均显著降低，观察组治疗后以上评分均低于对照组(P＜0.05)；两组治疗后血清MAD、DAO和D-乳酸水平均显著降低，SOD水平升高，观察组治疗后以上指标均优于对照组(P＜0.05)。两组治疗后的炎症性肠病生存质量问卷(IBDQ)中的肠道症状、全身症状、情感功能、社会功能和总评分均显著升高，观察组治疗后以上指标均高于对照组(P＜0.05)；观察组复发率低于对照组。结论：补充外源性维生素D可显著缓解老年UC患者病情，提高临床疗效，降低复发率，改善生活质量，其机制可能与其促进氧化-抗氧化平衡，保护肠道黏膜屏障有关。
Abstract:
Abstract Objective: To observe the effects of supplementation of exogenous vitamin D on oxidation-antioxidant imbalance, intestinal mucosa barrier and clinical prognosis in elderly patients with ulcerative colitis (UC). Methods:82 elderly patients with UC were randomly divided into observation group (n=40) and control group (n=42). The clinical effects of the two groups were recorded and the changes of modified Mayo score, oxidative stress and intestinal mucosal barrier before and after treatment were observed. Quality of life and recurrence rates were recorded in both groups. Results:Clinical efficacy of observation group was significantly higher than those in control group (P<0.05). After treatment, individual items (defecation times, hemafuria, endoscopic findings, overall evaluation) and total score of two groups were significantly reduced, and above scores of observation group were lower than control group. After treatment, levels of MAD, DAO and d-lactic acid were significantly decreased and SOD level was increased in both groups, and the above indexes were superior to those in the observation group. The intestinal symptoms, systemic symptoms, emotional function, social function and total IBDQ score after treatment in both groups were significantly increased, and the above indicators in the observation group were higher those in control group after treatment (P<0.05). The recurrence rate of the observation group was lower than that of the control group. Conclusion: Supplementation of exogenous vitamin D can significantly alleviate the condition of elderly patients with UC, improve clinical efficacy, reduce recurrence rate and improve quality of life. The mechanism may be related to promotion of oxidation-antioxidant balance and protection of intestinal mucosa barrier.

参考文献/References:


[1] 何敬堂, 何敬之, 那奕文,等. 柳氮磺胺吡啶与微生态制剂治疗溃疡性结肠炎32例[J]. 陕西医学杂志, 2016, 45(5):608-609.
[2] 明 荷, 谢 寒, 何 可. 康复新液联合美沙拉嗪治疗溃疡性结肠炎的疗效及对患者炎性因子和氧化应激水平的影响[J]. 世界华人消化杂志, 2015,23(4):684-688.
[3] 倪杰明,刘维新.肠黏膜屏障损伤在溃疡性结肠炎的作用研究进展[J].安徽医科大学学报,2018,53(5):815-818.
[4] 中华医学会消化病学分会炎症性肠病学组. 炎症性肠病诊断与治疗的共识意见(2012年·广州)[J]. 胃肠病学, 2012, 51(12):818-831.
[5] 郑发鹃, 张苏闽. 《炎症性肠病生存质量问卷》评估活动期溃疡性结肠炎患者生存质量[J]. 中医学报, 2015,32(8):1211-1214.
[6] 严海燕, 张晓俐, 李小芹,等. 氧化/抗氧化失衡与小儿溃疡性结肠炎的相关性研究[J]. 社区医学杂志, 2016, 14(4):65-66.
[7] 马 涛. 溃疡性结肠炎组织中NOX1、NOX2表达量与肠黏膜氧化应激反应、屏障功能损伤的相关性[J]. 海南医学院学报, 2017, 23(19):2638-2641.
[8] 石 涛, 卫江鹏, 刘 刚,等. 溃疡性结肠炎患者的肠屏障功能观察[J]. 中华医学杂志, 2015, 95(24):1941-1943.
[9] 张 帆. 双歧三联活菌胶囊联合甘草泻心汤对溃疡性结肠炎患者肠道菌群和肠黏膜屏障的影响[J]. 中国中西医结合消化杂志, 2017,25(9):690-693.〖ZK)〗
[10] 郑小娟, 郑海燕, 罗灵和,等. 枯草杆菌二联活菌肠溶胶囊联合美沙拉嗪肠溶片对溃疡性结肠炎患者的临床研究[J]. 中国临床药理学杂志, 2016,32(3):212-214.
[11] 王 宽, 黄任佳, 吴焕淦,等. 维生素D在炎症性肠病中的作用机制[J]. 世界华人消化杂志, 2015,23(35):5655-5661.
[12] 杨 蓉, 杨秀微. 溃疡性结肠炎患者辅以外源性维生素D治疗的抗复发作用观察[J]. 结直肠肛门外科, 2017，23(5):626-629.
[13] 孙睿森, 张 晶, 马 莹,等. 维生素C与维生素D3联合应用对葡聚糖硫酸钠造模的豚鼠溃疡性结肠炎的改善作用[J]. 现代预防医学, 2017, 44(8):1397-1341.
[14] 赵红伟, 郎晓猛, 朱叶珊,等. 1,25-二羟基维生素D3对溃疡性结肠炎小鼠免疫调节机制的研究[J]. 疑难病杂志, 2017, 16(5):496-499.
[15] 姚志伟, 周永宁. 维生素D治疗炎症性肠病的研究进展[J]. 胃肠病学和肝病学杂志, 2017, 26(7):827-831.

备注/Memo

备注/Memo:
*陕西省中医药管理局科研项目（15-SCJH028）
更新日期/Last Update: 2019-01-21