[1]兰静,曹彦丙.恩替卡韦联合霉酚酸酯治疗乙型肝炎病毒相关性肾炎疗效研究[J].陕西医学杂志,2018,(11):1490-1492.
　Lan Jing,CaoYanbing..The effect of Entecavir combined with Mycophenolate mofetil in the treatment of hepatitis B virus-associated nephritis[J].,2018,(11):1490-1492.
点击复制

恩替卡韦联合霉酚酸酯治疗乙型肝炎病毒相关性肾炎疗效研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1490-1492
栏目:
药物与临床
出版日期:
2018-11-29

文章信息/Info

Title:
The effect of Entecavir combined with Mycophenolate mofetil in the treatment of hepatitis B virus-associated nephritis
文章编号:
0.3969/j.issn.1000-7377.2018.11.037
作者:
兰静1; 曹彦丙2
1.山西省运城市第二医院肝病五科 （运城 044000）,2.山西省运城市第二医院肝胆外科（运城 044000）
Author(s):
Lan Jing; CaoYanbing.
Department of Hepatology, Yuncheng Second Hospital, Shanxi Province（Yuncheng 044000）
关键词:
肾炎乙型肝炎病毒@恩替卡韦@霉酚酸酯
Keywords:
NephritisHepatitis B vires@Entecavir@Mycophenolate mofetil
分类号:
R512.6
文献标志码:
A
摘要:
目的：探讨恩替卡韦联合霉酚酸酯治疗乙型肝炎病毒相关性肾炎的疗效和安全性。方法：选择18例乙型肝炎病毒相关性肾炎（HBV-GN）患者，采用经皮肾穿刺活检来明确病理特征。在一般治疗的同时，采用恩替卡韦联合霉酚酸酯治疗HBV-GN，对比该方案治疗前后，患者各项临床指标的变化情况及所有不良反应。同时回顾既往收治的15例HBV-GN患者，将其作为对照组，对照组仅在一般治疗的基础上联用恩替卡韦。结果：治疗组总有效率88.9%显著高于对照组的53.3%，两组比较有统计学差异（χ2=5.215,P=0.022）；两组患者治疗前24 h尿蛋白（UPRO）、血肌酐（Scr）、丙氨酸转氨酶（ALT）、天门冬氨酸转氨酶（AST）、白蛋白（ALB）及HBV-DNA比较无统计学差异（P＞0.05）；治疗后两组患者的UPRO、Scr、ALT和AST都有降低，ALB升高，但在治疗组患者中，各项临床治疗变化，有统计学差异（P＜0.05），而HBV-DNA治疗后表达变化，无统计学差异（P＞0.05）。结论：恩替卡韦联合霉酚酸酯治疗HBV-GN 疗效确切且安全性良好，具有一定的临床推广价值。
Abstract:
Objective: To investigate the efficacy and safety of entecavir combined with mycophenols in the treatment of hepatitis B virus related nephritis. Methods：18 patients with hepatitis B virus related nephritis(HBV-GN) were selected and pathologic features were identified by percutaneous renal biopsy. At the same time as the general treatment, the treatment of HBV-GN with entecavir and mildew phenolic Ester was used to compare the changes of clinical indicators and all adverse reactions before and after the treatment. At the same time, 15 cases of HBV-GN admitted to our hospital were reviewed as control groups. The control group only used entecavir on the basis of general treatment. Results：The results showed that the total effective rate was higher in the treatment group. There was no significant statistical difference between the two groups of patients treated with 24 h uria(UPRO), creatinine(Scr), alanine transaminase(ALT), aspartic acid transaminase(AST), albumin(ALB) and HBV-DNA(P＞0.05); After treatment, the UPRO, Scr, ALT, and AST of the two groups were all reduced and the ALB was increased. However, in the treatment group, the clinical treatment changes were significant and there were statistical differences(P＞0.05). The expression of HBV-DNA before and after treatment was not significant and there was no statistical difference(P＞0.05). Conclusion：Enticavir combined with mildew phenolic Ester is effective and safe in the treatment of HBV-GN.

参考文献/References:

[1]Xu F,Wang C,Shi X, et al. Resolution of HBV infection occurs sooner than recovery of renal disease in adult serum HBsAg-negative HBV-associated glomerulonephritis[J]. J Med Virol,2018, 90(9)：1503-1507.
[2]Zhao W,Ma Y,Wang M, et al. Expression of Foxp3 in renal tissue of patients with HBV-associated glomerulonephritis and their clinical and pathological characteristics[J]. Exp Ther Med,2017,14(5)：4928-4934.
[3]Peng T,Xie T,Liu L, et al. Analysis of clinical features and pathology of serum HBsAg positive glomerulonephritis[J]. J Med Virol,2018, 90(3)：612-615.
[4]王祝娟.乙型肝炎病毒相关性肾炎40例临床分析[J].陕西医学杂志,2014,43(7):856-857,858.
[5]Khedmat H,Taheri S. Hepatitis B virus-associated nephropathy: an international data analysis[J]. Iran J Kidney Dis, 2010, 4(2)：101-105.
[6]袁瑾,孙吉平,何旺.正清风痛宁联合拉米夫定治疗乙型肝炎病毒相关性肾炎34例[J].陕西中医,2014,35(9)：1176-1178.
[7]Wang L,Ye Z,Liang H, et al. The combination of tacrolimus and entecavir improves the remission of HBV-associated glomerulonephritis without enhancing viral replication[J]. Am J Transl Res,2016, 8(3)：1593-600.
[8]Zheng XY,Wei RB,Tang L,et al.Meta-analysis of combined therapy for adult hepatitis B virus-associated glomerulonephritis[J]. World J Gastroenterol,2012,18(8)：821-832.
[9]蔡建芳，窦晓丽，文煜冰，等. 乙型肝炎病毒相关性肾炎的相关因素分析[J]. 中华肾脏病杂志，2011，27(2)：96-99.
[10]李淑娟.恩替卡韦联合来氟米特治疗乙肝病毒相关性肾炎的疗效[J]. 中国实用医药,2012,7(2)：143-144.
[11]周兰,何庆忠. 恩替卡韦联合霉酚酸酯治疗乙型肝炎病毒相关性肾炎30 例临床分析[J]. 现代医药卫生,2013,29(3)：329-330.
[12]许桂军. 吗替麦考酚酯治疗膜性肾病44例[J]. 中国药业, 2013,22(11)：154-155.

更新日期/Last Update: 2018-11-30